Sarah R Chang, Rudi Kobetic, Musa L Audu, Roger D Quinn, Ronald J Triolo
{"title":"Powered Lower-Limb Exoskeletons to Restore Gait for Individuals with Paraplegia - a Review.","authors":"Sarah R Chang, Rudi Kobetic, Musa L Audu, Roger D Quinn, Ronald J Triolo","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Individuals with paraplegia due to spinal cord injury rank restoration of walking high on the list of priorities to improving their quality of life. Powered lower-limb exoskeleton technology provides the ability to restore standing up, sitting down, and walking movements for individuals with paraplegia. The robotic exoskeletons generally have electrical motors located at the hip and knee joint centers, which move the wearers' lower limbs through the appropriate range of motion for gait according to control systems using either trajectory control or impedance control. Users of exoskeletons are able to walk at average gait speeds of 0.26 m/s and distances ranging between 121-171 m. However, the achieved gait speeds and distances fall short of those required for full community ambulation (0.8 m/s and at least 230 m), restricting use of the devices to limited community use with stand-by assist or supervised rehabilitation settings. Improvement in the gait speed and distance may be achievable by combining a specially designed powered exoskeleton with neuromuscular stimulation technologies resulting in a hybrid system that fully engages the user and achieves the necessary requirements to ambulate in the community environment with benefits of muscle contraction.</p>","PeriodicalId":91223,"journal":{"name":"Case orthopaedic journal","volume":"12 1","pages":"75-80"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5166705/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141201744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"THE COP9 SIGNALOSOME, A NOVEL, ESSENTIAL REGULATOR OF SKELETAL DEVELOPMENT AND TUMORIGENESIS.","authors":"Lindsay Bashur, Dongxing Chen, Guang Zhou","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In recent years, the evolutionarily conserved complex named COP9 signalosome has emerged as an essential and versatile regulator of biological and pathological responses across species. Various components of COP9 signalosome, including CSN5 (also named JAB1), play critical roles in a wide array of developmental process. Using genetically engineered mouse models, our laboratory has recently identified CSN5/JAB1 as an essential regulator of skeletal development, in part through negatively regulating BMP signaling. BMP signaling is important for fracture healing and bone regeneration. BMPs have been used for treating acute fractures and for improving the success of spinal fusions. Therefore, harnessing the CSN5/JAB1-mediated inhibition of BMP signaling might be a novel strategy to improve the efficacy of BMP treatment and to reduce medical costs in the future. Furthermore, the up-regulation of COP9 signalosome has been associated with various cancers, including osteosarcoma. Thus, the COP9 signalosome can also be a valid target for treating osteosarcoma and other tumors.</p>","PeriodicalId":91223,"journal":{"name":"Case orthopaedic journal","volume":"8 1","pages":"45-50"},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4722531/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140195250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}