Metalloproteinases in medicine最新文献

ADAMDEC1 and Its Role in Inflammatory Disease and Cancer ADAMDEC1及其在炎症性疾病和癌症中的作用

Metalloproteinases in medicine Pub Date : 2020-08-01 DOI: 10.2147/mnm.s263813

T. Kumagai, S. Fan, A. M. Smith

{"title":"ADAMDEC1 and Its Role in Inflammatory Disease and Cancer","authors":"T. Kumagai, S. Fan, A. M. Smith","doi":"10.2147/mnm.s263813","DOIUrl":"https://doi.org/10.2147/mnm.s263813","url":null,"abstract":": A disintegrin and metalloprotease like decysin (ADAMDEC1) is a highly conserved secreted metalloprotease that belongs to a family of A disintegrin and metalloprotease (ADAMs). It is expressed exclusively in the gastrointestinal tract of animals and is known to possess a very rare zinc-binding motif (HEXXHXXGXXD) within the metalloprotease domain. The biological function of ADAMDEC1 as well as its true biological substrates remains unknown although its characteristic features reported to date suggest it plays a fundamental role in the physiology of mammals. Historically its expression, in healthy state, was believed to be limited to the monocyte-derived macrophages (MDMs) and dendritic cells within the gastrointestinal tract; however, the recent development of single-cell sequencing has provided evidence supporting its expression in a wider range of cell types. There is an increasing body of evidence linking the alterations in ADAMDEC1 expression and various inflammatory diseases and cancers. Although a detailed mechanistic role of ADAMDEC1 in these conditions remains elusive. In this review, we aim to summarise the characteristic features of this unique metalloprotease, discuss the associations with various human diseases and define the potential mechanistic role of ADAMDEC1 in mammalian physiology.","PeriodicalId":91141,"journal":{"name":"Metalloproteinases in medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2147/mnm.s263813","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42420149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

The role of tissue inhibitors of metalloproteinases in microvascular endothelial cell barrier dysfunction during sepsis 金属蛋白酶组织抑制剂在败血症期间微血管内皮细胞屏障功能障碍中的作用

Metalloproteinases in medicine Pub Date : 2019-05-07 DOI: 10.2147/MNM.S156245

Devika P Jayawardena, Nidhi P Kulkarni, S. Gill

引用次数: 3

Current insights into matrix metalloproteinases and glioma progression: transcending the degradation boundary 目前对基质金属蛋白酶和胶质瘤进展的见解:超越降解边界

Metalloproteinases in medicine Pub Date : 2018-09-01 DOI: 10.2147/MNM.S105123

Nicholas Pullen, A. Pickford, M. Perry, D. Jaworski, Katie F. Loveson, D. Arthur, J. Holliday, T. Van Meter, R. Peckham, W. Younas, S. Briggs, Sophie MacDonald, Thomas M. Butterfield, Myrianni Constantinou, H. Fillmore

引用次数: 14

dCas9-mediated transcriptional activation of tissue inhibitor of metalloproteinases. dcas9介导的金属蛋白酶组织抑制剂的转录激活。

Metalloproteinases in medicine Pub Date : 2017-01-01 Epub Date: 2017-09-19 DOI: 10.2147/MNM.S146752

Tyler Duellman, Andrea Doll, Xi Chen, Rie Wakamiya, Jay Yang

{"title":"dCas9-mediated transcriptional activation of tissue inhibitor of metalloproteinases.","authors":"Tyler Duellman, Andrea Doll, Xi Chen, Rie Wakamiya, Jay Yang","doi":"10.2147/MNM.S146752","DOIUrl":"https://doi.org/10.2147/MNM.S146752","url":null,"abstract":"Selective gene activation with the dCas9 (deactivated clustered regularly interspaced short palindromic repeats [CRISPR] associated protein 9)/CRISPR targeting of a transcriptional activator effector is now well established. However, the optimal targeting of guide RNA (gRNA) for a given gene is largely a matter of trial and error. We explored the optimal targeting site for tissue inhibitor of metalloproteinases (TIMPs) by first screening multiple gRNA target sites using a luciferase-based promoter-reporter system and next confirmed the effective TIMP induction in the mouse motor neuron-like neuron-enriched spinal cord 34 (NSC34) cells. Screening of many gRNAs targeting the 1-1.9 kB promoter regions of TIMP1-3 identified several hot-spots for optimal gene induction, however, no general pattern defining the optimal target site with respect to the proximity of known transcription factor binding sites or distance from the start ATG was apparent. TIMP2 with a larger basal transcriptional activity showed a greater fold-induction with gRNA compared with TIMP1 or 3 supporting the importance of an open-chromatin for best gRNA-mediated transcriptional induction. The rank order of induction potency for different gRNA identified in the promoter-reporter screening held true for the NSC34 cells. Co-activation with multiple gRNAs greatly increased the gene induction.","PeriodicalId":91141,"journal":{"name":"Metalloproteinases in medicine","volume":"4 ","pages":"63-73"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2147/MNM.S146752","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35574025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Emergence of a metalloproteinase / phospholipase A2 axis of systemic inflammation. 出现系统性炎症的金属蛋白酶/磷脂酶A2轴。

Metalloproteinases in medicine Pub Date : 2015-08-13 DOI: 10.2147/MNM.S48748

Carlos Fernandez-Patron, Dickson Leung

{"title":"Emergence of a metalloproteinase / phospholipase A2 axis of systemic inflammation.","authors":"Carlos Fernandez-Patron, Dickson Leung","doi":"10.2147/MNM.S48748","DOIUrl":"https://doi.org/10.2147/MNM.S48748","url":null,"abstract":"We review select aspects of the biology of matrix metalloproteinases (MMPs) with a focus on the modulation of inflammatory responses by MMP-2. MMP-2 is a zinc- and calcium-dependent endoprotease with substrates including extracellular matrix proteins, vasoactive peptides and chemokines. Humans and mice with MMP-2 deficiency exhibit a predominantly inflammatory phenotype. Recent research shows that MMP-2 deficient mice display elevated activity of a secreted phospholipase A2 in the heart. Additionally, MMP-2 deficient mice exhibit abnormally high prostaglandin E2 levels in various organs (i.e., the heart, brain and liver), signs of inflammation and exacerbated lipopolysaccharide-induced fever. We briefly review the biology of sPLA2 enzymes to propose the existence of a heart-centric MMP-2/sPLA2 axis of systemic inflammation. Moreover, we postulate that PLA2 activation is induced by chemokines, whose ability to signal inflammation is regulated in a tissue-specific fashion by MMPs. Thus, genetic and pharmacologically induced MMP-deficiencies can be expected to perturb PLA2-mediated inflammatory mechanisms.","PeriodicalId":91141,"journal":{"name":"Metalloproteinases in medicine","volume":"2 ","pages":"29-38"},"PeriodicalIF":0.0,"publicationDate":"2015-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2147/MNM.S48748","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34278553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Using the laws of thermodynamics to understand how matrix metalloproteinases coordinate the myocardial response to injury. 利用热力学定律了解基质金属蛋白酶如何协调心肌对损伤的反应。

Metalloproteinases in medicine Pub Date : 2015-01-01 Epub Date: 2015-10-30 DOI: 10.2147/MNM.S74093

Rugmani Padmanabhan Iyer, Mira Jung, Merry L Lindsey

引用次数: 4