Journal of stem cell and transplantation biology最新文献

Xeno-Transplantation of macro-encapsulated islets and Pluripotent Stem Cell-Derived Pancreatic Progenitors without Immunosuppression. 无免疫抑制的大包膜胰岛和多能干细胞衍生胰腺祖细胞异种移植。

Journal of stem cell and transplantation biology Pub Date : 2017-05-29 DOI: 10.19104/JORM.2017.109

M. A. Bukys, Brandon Bakos, Solomon Afelik, Baruch Zimmerman, B. Barbaro, D. Lin, P. Vaca, T. Goldman, A. Rotem, M. Damaser, J. Oberholzer, U. Barkai, J. Jensen

{"title":"Xeno-Transplantation of macro-encapsulated islets and Pluripotent Stem Cell-Derived Pancreatic Progenitors without Immunosuppression.","authors":"M. A. Bukys, Brandon Bakos, Solomon Afelik, Baruch Zimmerman, B. Barbaro, D. Lin, P. Vaca, T. Goldman, A. Rotem, M. Damaser, J. Oberholzer, U. Barkai, J. Jensen","doi":"10.19104/JORM.2017.109","DOIUrl":"https://doi.org/10.19104/JORM.2017.109","url":null,"abstract":"Islet transplantation effectively treats diabetes but relies on immune suppression and is practically limited by the number of cadaveric islets available. An alternative cellular source is insulin-producing cells derived from pluripotent cell sources. Three animal cohorts were used in the current study to evaluate whether an oxygen-providing macro-encapsulation device, 'βAIR', could function in conjunction with human embryonic stem cells (hESCs) and their derivatives. The first cohort received macro-encapsulated undifferentiated hESCs, a second cohort received hESCs differentiated to a pancreatic progenitor state with limited endocrine differentiation. A reference cohort received human islets. Macro-encapsulation devices were implanted subcutaneously and monitored for up to 4 months. Undifferentiated pluripotent stem cells did not form teratoma but underwent cell death following implantation. Human C-peptide (hC- peptide) was detectable in host serum one week after implantation for both other cohorts. hC-peptide levels decreasing over time but remained detectable up to the end of the study. Key factors associated with mature endocrine cells were observed in grafts recovered from cohorts containing islets and hESC-derivatives including C-peptide, insulin, glucagon and urocortin 3. We conclude that the 'βAIR' macroencapsulation device is compatible with both human islets and pluripotent derivatives, but has a limited capability of sustaining undifferentiated pluripotent cells.","PeriodicalId":91131,"journal":{"name":"Journal of stem cell and transplantation biology","volume":"122 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88256348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

A Young Patient with Refractory Multiple Myeloma and Dialysis-Dependent Renal Failure has been Cured by Non-Cryopreserved Autologous Stem Cell Transplantation Followed by Live-Related Kidney Transplantation 一名年轻的难治性多发性骨髓瘤和透析依赖性肾衰竭患者通过非冷冻保存的自体干细胞移植和活体肾移植治愈

Journal of stem cell and transplantation biology Pub Date : 2017-01-01 DOI: 10.21767/2575-7725.100013

K. Al-Anazi, J. Bacal, Nihad Mokhtar, Mohammed Kawari, H. Alhashmi, O. Abduljalil, E. Alshaibani, P. Kalogiannidis, A. Estanislao, A. AlJatham, AlBahrani At, K. Akkari

{"title":"A Young Patient with Refractory Multiple Myeloma and Dialysis-Dependent Renal Failure has been Cured by Non-Cryopreserved Autologous Stem Cell Transplantation Followed by Live-Related Kidney Transplantation","authors":"K. Al-Anazi, J. Bacal, Nihad Mokhtar, Mohammed Kawari, H. Alhashmi, O. Abduljalil, E. Alshaibani, P. Kalogiannidis, A. Estanislao, A. AlJatham, AlBahrani At, K. Akkari","doi":"10.21767/2575-7725.100013","DOIUrl":"https://doi.org/10.21767/2575-7725.100013","url":null,"abstract":"Management of patients with multiple myeloma having dialysis-dependent renal failure, particularly if the disease is refractory to several lines of therapy, is a difficult task. Cure of such patients represents a real challenge to the treating team. In late November 2009, the diagnosis of multiple myeloma was made in a young patient who had been receiving regular hemodialysis for end-stage renal disease. His myeloma was refractory to four lines of therapy and it responded partially to the fifth line of treatment. Thereafter, the patient received a noncryopreserved autologous hematopoietic stem cell transplantation which brought his myeloma under more optimal control. One year later, he received live-related kidney transplantation. During his subsequent follow-up for fifty four months post-renal transplantation at King Fahad Specialist Hospital in Dammam, Saudi Arabia, no complication has been encountered. As the case is complicated, the literature review will be detailed in order to discuss the various aspects related to care of the patient presented.","PeriodicalId":91131,"journal":{"name":"Journal of stem cell and transplantation biology","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88311802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

It's Getting Hot in Here: Targeting Cancer Stem-like Cells with Hyperthermia. 这里越来越热:用高温疗法靶向癌症干细胞。

Journal of stem cell and transplantation biology Pub Date : 2017-01-01 Epub Date: 2017-12-29

Haidong Huang, Kevin Yu, Alireza Mohammadi, Efstathios Karanthanasis, Andrew Godley, Jennifer S Yu

引用次数: 0

Homeodomain Transcription Factor Msx-2 Regulates Uterine Progenitor Cell Response to Diethylstilbestrol. 同源结构域转录因子Msx-2调控子宫祖细胞对己烯雌酚的应答。

Journal of stem cell and transplantation biology Pub Date : 2015-01-01 Epub Date: 2015-05-12 DOI: 10.19104/jstb.2015.105

Yan Yin, Congxing Lin, Ivy Zhang, Alexander V Fisher, Maulik Dhandha, Liang Ma

{"title":"Homeodomain Transcription Factor Msx-2 Regulates Uterine Progenitor Cell Response to Diethylstilbestrol.","authors":"Yan Yin, Congxing Lin, Ivy Zhang, Alexander V Fisher, Maulik Dhandha, Liang Ma","doi":"10.19104/jstb.2015.105","DOIUrl":"https://doi.org/10.19104/jstb.2015.105","url":null,"abstract":"The fate of mouse uterine epithelial progenitor cells is determined between postnatal days 5 to 7. Around this critical time window, exposure to an endocrine disruptor, diethylstilbestrol (DES), can profoundly alter uterine cytodifferentiation. We have shown previously that a homeo domain transcription factor MSX-2 plays an important role in DES-responsiveness in the female reproductive tract (FRT). Mutant FRTs exhibited a much more severe phenotype when treated with DES, accompanied by gene expression changes that are dependent on Msx2. To better understand the role that MSX-2 plays in uterine response to DES, we performed global gene expression profiling experiment in mice lacking Msx2 By comparing this result to our previously published microarray data performed on wild-type mice, we extracted common and differentially regulated genes in the two genotypes. In so doing, we identified potential downstream targets of MSX-2, as well as genes whose regulation by DES is modulated through MSX-2. Discovery of these genes will lead to a better understanding of how DES, and possibly other endocrine disruptors, affects reproductive organ development.","PeriodicalId":91131,"journal":{"name":"Journal of stem cell and transplantation biology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4596533/pdf/nihms-723300.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34248175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Heart Regeneration with Embryonic Cardiac Progenitor Cells and Cardiac Tissue Engineering. 胚胎心脏祖细胞与心脏组织工程的心脏再生。

Journal of stem cell and transplantation biology Pub Date : 2015-01-01 DOI: 10.19104/JSTB.2015.104

Shuo Tian, Qihai Liu, Leonid Gnatovskiy, P. Ma, Zhong Wang

引用次数: 19