Journal of personalized nanomedicine最新文献

筛选
英文 中文
Macrophage Targeted Nanoparticles for Antiretroviral (ARV) Delivery. 用于递送抗逆转录病毒 (ARV) 的巨噬细胞靶向纳米颗粒。
Journal of personalized nanomedicine Pub Date : 2015-11-01 Epub Date: 2015-11-14
Hilliard L Kutscher, Faithful Makita-Chingombe, Sara DiTursi, Ajay Singh, Admire Dube, Charles C Maponga, Gene D Morse, Jessica L Reynolds
{"title":"Macrophage Targeted Nanoparticles for Antiretroviral (ARV) Delivery.","authors":"Hilliard L Kutscher, Faithful Makita-Chingombe, Sara DiTursi, Ajay Singh, Admire Dube, Charles C Maponga, Gene D Morse, Jessica L Reynolds","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>To reduce the amount of the antiretroviral (ARV) nevirapine necessary to achieve therapeutic concentrations using macrophage targeted nanoparticles.</p><p><strong>Methods: </strong>Core-shell nanoparticles were prepared from FDA approved, biodegradable and biocompatible polymers, with poly(lactic-co-glycolic) acid (PLGA) as the core and chitosan (CS) as the shell using a water/oil/water method. Nevirapine was encapsulated in the core of the nanoparticles. β-glucan (GLU) was adsorbed to the surface of the nanoparticle. Macrophage uptake and intracellular nevirapine concentrations were determined by fluorescence imaging and ultra-performance liquid chromatography/mass spectroscopy (UPLC-MS). Optical imaging was employed to characterize the biodistribution of nanoparticles following intravenous injection in CD-1 mice.</p><p><strong>Results: </strong>We synthesized spherical shaped 190 nm GLU-CS-PLGA nanoparticles that provide controlled release of nevirapine. In THP-1 macrophage the uptake of PLGA and CS- PLGA nanoparticles was less compared to targeted GLU-CS-PLGA nanoparticles. THP-1 macrophage were dosed with free nevirapine (10 μg/well) and GLU-CS- PLGA nanoparticles containing 1/10 the concentration of free nevirapine (1 μg nevirapine/well). The intracellular concentration of nevirapine was the same for both nanoparticles and free nevirapine at 2 and 24 hrs. No significant change in THP-1 macrophage viability was observed in the presence of nanoparticles relative to the control. <i>Ex vivo</i> imaging demonstrates that nanoparticles are predominantly found in the liver and kidney and at 24 hr there is still a large amount of nanoparticles in the body.</p><p><strong>Conclusion: </strong>These data demonstrate that the total dose of nevirapine delivered by GLU-CS-PLGA nanoparticles can be greatly reduced, to limit side effects, while still providing maximal ARV activity in a known cellular reservoir.</p>","PeriodicalId":91128,"journal":{"name":"Journal of personalized nanomedicine","volume":"1 2","pages":"40-48"},"PeriodicalIF":0.0,"publicationDate":"2015-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5826576/pdf/nihms859399.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35873868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nanostructured Gas Sensors for Health Care: An Overview. 用于医疗保健的纳米结构气体传感器:概述。
Journal of personalized nanomedicine Pub Date : 2015-07-01 Epub Date: 2015-07-27
Ajeet Kaushik, Rajesh Kumar, Rahul Dev Jayant, Madhavan Nair
{"title":"Nanostructured Gas Sensors for Health Care: An Overview.","authors":"Ajeet Kaushik, Rajesh Kumar, Rahul Dev Jayant, Madhavan Nair","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Nanostructured platforms have been utilized for fabrication of small, sensitive and reliable gas sensing devices owing to high functionality, enhanced charge transport and electro-catalytic property. As a result of globalization, rapid, sensitive and selective detection of gases in environment is essential for health care and security. Nonmaterial such as metal, metal oxides, organic polymers, and organic-inorganic hybrid nanocomposites exhibit interesting optical, electrical, magnetic and molecular properties, and hence are found potential gas sensing materials. Morphological, electrical, and optical properties of such nanostructures can be tailored via controlling the precursor concentration and synthesis conditions resulting to achieve desired sensing. This review presents applications of nano-enabling gas sensors to detect gases for environment monitoring. The recent update, challenges, and future vision for commercial applications of such sensor are also described here.</p>","PeriodicalId":91128,"journal":{"name":"Journal of personalized nanomedicine","volume":"1 1","pages":"10-23"},"PeriodicalIF":0.0,"publicationDate":"2015-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4610411/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34107076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信