Journal of nephrology research最新文献

Is Response to Enuresis Treatment with Desmopressin Influenced by Family History, Associated Comorbidities or Obesity? 去氨加压素治疗遗尿反应受家族史、相关合并症或肥胖影响吗?

Journal of nephrology research Pub Date : 2019-03-20 DOI: 10.17554/j.issn.2410-0579.2019.05.38

M. Kopač

{"title":"Is Response to Enuresis Treatment with Desmopressin Influenced by Family History, Associated Comorbidities or Obesity?","authors":"M. Kopač","doi":"10.17554/j.issn.2410-0579.2019.05.38","DOIUrl":"https://doi.org/10.17554/j.issn.2410-0579.2019.05.38","url":null,"abstract":"Aim : To evaluate the role of family history of enuresis, associated comorbidities and body mass index in predicting response to enuresis treatment with desmopressin in children. Materials amd methods : 100 patients with monosymptomatic enuresis were evaluated in this retrospective study. The associations between family history of enuresis, associated comorbidities, body mass index and response to enuresis treatment with desmopressin were analysed with χ 2 statistical test. Results : Family history of enuresis was positive in 58.8 % of patients who responded to desmopressin treatment and in 54.5 % of non-responders. Among patients who responded to desmopressin treatment, obesity was present in 14.3 % and overweight in 19 % of patients. Among non-responders, obesity was present in 13.2 % and overweight in 7.9 % of patients. Among patients who responded to desmopressin treatment, comorbidity was present in 40.5 % of patients. Among 38 non-responders, comorbidity was present in 21.1 % of patients. The difference was not statistically significant in either of compared groups. Conclusion : The study did not prove statistically significant association between family history of enuresis, associated comorbidities or body mass index, and response to treatment with desmopressin.","PeriodicalId":91126,"journal":{"name":"Journal of nephrology research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43990564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

βENaC acts as a mechanosensor in renal vascular smooth muscle cells that contributes to renal myogenic blood flow regulation, protection from renal injury and hypertension. βENaC作为肾血管平滑肌细胞的机械传感器，参与肾肌源性血流调节，防止肾损伤和高血压。

Journal of nephrology research Pub Date : 2015-06-26 DOI: 10.17554/J.ISSN.2410-0579.2015.01.12

H. Drummond, D. Stec

{"title":"βENaC acts as a mechanosensor in renal vascular smooth muscle cells that contributes to renal myogenic blood flow regulation, protection from renal injury and hypertension.","authors":"H. Drummond, D. Stec","doi":"10.17554/J.ISSN.2410-0579.2015.01.12","DOIUrl":"https://doi.org/10.17554/J.ISSN.2410-0579.2015.01.12","url":null,"abstract":"Pressure-induced constriction (also known as the \"myogenic response\") is an important mechanodependent response in small renal arteries and arterioles. The response is initiated by vascular smooth muscle cell (VSMC) stretch due to an increase in intraluminal pressure and leads to vasoconstriction. The myogenic response has two important roles as a mechanism of local blood flow autoregulation and protection against systemic blood pressure-induced microvascular damage. However, the molecular mechanisms underlying initiation of myogenic response are unresolved. Although several molecules have been considered initiators of the response, our laboratory has focused on the role of degenerin proteins because of their strong evolutionary link to mechanosensing in the nematode. Our laboratory has addressed the hypothesis that certain degenerin proteins act as mechanosensors in VSMCs. This article discusses the importance of a specific degenerin protein, β Epithelial Na+ Channel (βENaC), in pressure-induced vasoconstriction, renal blood flow and susceptibility to renal injury. We propose that loss of the renal myogenic constrictor response delays the correction of renal blood flow that occurs with fluctuations in systemic pressure, which allows pressure swings to be transmitted to the microvasculature, thus increasing the susceptibility to renal injury and hypertension. The role of βENaC in myogenic regulation is independent of tubular βENaC and thus represents a non-tubular role for βENaC in renal-cardiovascular homeostasis.","PeriodicalId":91126,"journal":{"name":"Journal of nephrology research","volume":"1 1 1","pages":"1-9"},"PeriodicalIF":0.0,"publicationDate":"2015-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67620292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Bladder cancer and urinary Schistosomiasis in Angola. 安哥拉的膀胱癌和尿路血吸虫病。

Journal of nephrology research Pub Date : 2015-06-01 DOI: 10.17554/j.issn.2410-0579.2015.01.4

Monica C Botelho, Jacinta Figueiredo, Helena Alves

{"title":"Bladder cancer and urinary Schistosomiasis in Angola.","authors":"Monica C Botelho, Jacinta Figueiredo, Helena Alves","doi":"10.17554/j.issn.2410-0579.2015.01.4","DOIUrl":"https://doi.org/10.17554/j.issn.2410-0579.2015.01.4","url":null,"abstract":"Schistosomiasis haematobia is among the most prevalent parasitosis in Angola. The pathology is characterized by serious and irreversible lesions in the urogenital tract induced by chronic infection with the parasite that can eventually lead to squamous cell carcinoma of the bladder. Considering the frequency and severe morbidity observed, even in younger ages, the purpose of this study was to assess the prevalence and morbidity of S. haematobium infection in Angola. A baseline survey was conducted between November 2007 and February 2008. A randomly sample of 300 inhabitants aged 15 to 75 years old participated in this study. Prevalence of S. haematobium infection was 71.7 % (215/300). Infection was higher in females (56.3 %) but no significant difference was found in prevalence and intensity between gender and age groups. The predominant selfreported symptoms were dysuria (91.2 %), hypogastralgia (88.7 %) and haematuria (87.1%) and these symptoms were strongly associated with S. haematobium infection (p<0.05). Ultrasound and cystoscopy examinations performed in a sub-sample of 29 individuals revealed pathological conditions at the urinary tract in all examined. Considering the high prevalence of S. haematobium infections in Angola and schistosomiasis-associated bladder cancer, our results indicate that this population should be targeted for follow up and implementation of measures for treatment and control of schistosomiasis.","PeriodicalId":91126,"journal":{"name":"Journal of nephrology research","volume":"1 1","pages":"22-24"},"PeriodicalIF":0.0,"publicationDate":"2015-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4497783/pdf/nihms683305.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34283196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 18

Diagnosis and Management of Obstructive Uropathy in the Setting of Advanced Pelvic Malignancies. 晚期盆腔恶性肿瘤患者梗阻性尿病的诊断和治疗。

Journal of nephrology research Pub Date : 2015-01-01 Epub Date: 2015-12-29

Grace G Zhu, Soroush Rais-Bahrami

{"title":"Diagnosis and Management of Obstructive Uropathy in the Setting of Advanced Pelvic Malignancies.","authors":"Grace G Zhu, Soroush Rais-Bahrami","doi":"","DOIUrl":"","url":null,"abstract":"Obstructive uropathy is a common urological problem, with a variety of etiologies, ranging from benign to malignant processes, extrinsic to intrinsic conditions. Its presentation depends largely on the location of the obstructive lesion and the acuity of the obstruction. Lower versus upper urinary tract obstruction present differently. A wide variety of imaging tools can aid in diagnosing the obstructive process and help delineate the etiology and the location of the obstruction. Treatment is geared towards alleviating the obstruction, either by restoring the normal urinary flow within the urinary tract by utilizing a ureteral stent for upper urinary tract obstruction or urethral catheters for lower urinary tract obstruction, or by diverting the urine by placing a percutaneous nephrostomy tube or suprapubic catheters. Pelvic malignancies are a subset of the many causes of obstructive uropathy and have unique considerations in treatment. Future directions in the realm of management of obstructive uropathy should focus on maximizing urinary drainage while minimizing the morbidities associated with the current available treatment options.","PeriodicalId":91126,"journal":{"name":"Journal of nephrology research","volume":"1 3","pages":"90-96"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11293738/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141876932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0