Journal of cardiology and therapeutics最新文献

{"title":"Heart Failure: A Systematic Approach under of Disease Treatment Perspective","authors":"Vinicius Rocha, A. Costa, L. Ferreira, Luiz Santos, Márcio A Santos, J. Toledo, H. Souza, I. Guimaraes, R. Santos, L. Antunes, J. Godoy, Rogério Ramos","doi":"10.12970/2311-052x.2021.09.01","DOIUrl":"https://doi.org/10.12970/2311-052x.2021.09.01","url":null,"abstract":"","PeriodicalId":91107,"journal":{"name":"Journal of cardiology and therapeutics","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84802197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anomalous Coronary Arteries: Two Unique Cases as Viewed by Invasive Angiography with Brief Review of Literature","authors":"M. Hafid","doi":"10.12970/2311-052x.2020.08.01","DOIUrl":"https://doi.org/10.12970/2311-052x.2020.08.01","url":null,"abstract":"","PeriodicalId":91107,"journal":{"name":"Journal of cardiology and therapeutics","volume":"59 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79834279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful Trans-Radial Coronary Intervention through “Arteria Lusoria”","authors":"K. Munde, S. Shaikh, V. Deshmukh, M. Phutane, Rahul Singla, Zahidullah Khan","doi":"10.12970/2311-052X.2018.06.03","DOIUrl":"https://doi.org/10.12970/2311-052X.2018.06.03","url":null,"abstract":"","PeriodicalId":91107,"journal":{"name":"Journal of cardiology and therapeutics","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89267367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiac Allograft Vasculopathy: Pathogenesis and Role of Coronary Computed Tomography Angiography in the Diagnosis and Surveillance","authors":"N. Madan, Panagiota Christia, R. Faillace","doi":"10.12970/2311-052X.2018.06.02","DOIUrl":"https://doi.org/10.12970/2311-052X.2018.06.02","url":null,"abstract":"","PeriodicalId":91107,"journal":{"name":"Journal of cardiology and therapeutics","volume":"42 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78426539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cannabinoid Receptor Type 2 (CB2) Dependent and Independent Effects of WIN55,212-2 on Atherosclerosis in Ldlr-null Mice.","authors":"Courtney Netherland-Van Dyke,&nbsp;Ward Rodgers,&nbsp;Makenzie Fulmer,&nbsp;Zachary Lahr,&nbsp;Douglas Thewke","doi":"10.12970/2311-052X.2015.03.02.2","DOIUrl":"https://doi.org/10.12970/2311-052X.2015.03.02.2","url":null,"abstract":"<p><strong>Purpose: </strong>WIN55,212-2, a potent synthetic agonist of cannabinoid receptor type 1 (CB1) and cannabinoid receptor type 2 (CB2), reduces atherosclerosis in apolipoprotein E (ApoE) null mice. Although pharmacologic evidence suggests the anti-atherosclerotic effects of WIN55,212-2 are mediated <i>via</i> CB2, this remains to be confirmed by genetic studies. Therefore, in this study, we investigated the effects of WIN55,212-2 on development of atherosclerosis in low-density lipoprotein receptor (Ldlr) null mice with and without homozygous deletion of the CB2 gene.</p><p><strong>Methods: </strong>After 6 weeks on an atherogenic diet, groups of CB2^+/+ and CB2^-/- Ldlr-null mice received a daily intraperitoneal injection of WIN55,212-2 or vehicle. After two weeks, plasma lipid levels and atherosclerosis in the aortic root were quantified.</p><p><strong>Results: </strong>Plasma cholesterol and triglyceride levels did not differ between CB2^+/+ and CB2^-/- mice and WIN55,212-2 had no effect on total cholesterol levels in either genotype. However, triglyceride levels in both CB2^+/+ and CB2^-/- mice were significantly lowered by WIN55,212-2. The size of aortic root lesions did not differ significantly between CB2^+/+ and CB2^-/- mice with or without WIN55,212-2 treatment. However, WIN55,212-2 treatment significantly lowered lesional macrophage accumulation in CB2^+/+ mice, and lesional smooth muscle content in both CB2^+/+ and CB2^-/- mice. Lesional apoptosis was also greater in CB2^+/+ mice compared to CB2^-/-mice, and only reduced by WIN55,212-2 in CB2^+/+ mice. Collagen content and elastin fiber fragmentation were unaffected by genotype or WIN55,212-2.</p><p><strong>Conclusions: </strong>WIN55,212-2 treatment does not alter lesion size in Ldlr null-mice, but does modify lesion cellularity <i>via</i> CB2-dependent and CB2-independent mechanisms.</p>","PeriodicalId":91107,"journal":{"name":"Journal of cardiology and therapeutics","volume":"3 2","pages":"53-63"},"PeriodicalIF":0.0,"publicationDate":"2015-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4581537/pdf/nihms722232.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34042799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiovascular Risk Factors from Early Life Predict Future Adult Cardiac Structural and Functional Abnormalities: A Systematic Review of the Published Literature.","authors":"Arjun K Ghosh, Darrel P Francis, Nishi Chaturvedi, Diana Kuh, Jamil Mayet, Alun D Hughes, Rebecca J Hardy","doi":"10.12970/2311-052X.2014.02.02.4","DOIUrl":"10.12970/2311-052X.2014.02.02.4","url":null,"abstract":"<p><strong>Background: </strong>Clinical practice evaluates cardiovascular risk based on current risk factor (RF) levels [Blood pressure (BP), body mass index (BMI) and glycaemic control] largely disregarding previous risk-factor history over the totality of the life course. RFs are related to contemporaneous echocardiographic measures of cardiac structure and function which in turn are independently related to cardiovascular morbidity and mortality in cross-sectional studies. However, the effect of lifetime or earlier RF history on future echocardiographic changes has never been systematically examined.</p><p><strong>Methods: </strong>A systematic review of the published literature identified 24 studies relating either earlier BP, BMI, glycaemic control or a combination to future cardiac structure and/or function.</p><p><strong>Results: </strong>The majority of studies showed that elevated BP and BMI in earlier life and greater cumulative burden of these factors resulted in worse cardiac structure up to 24 years later. Studies examining glycaemic control as RF were few, but poorer glycaemic control in young adults was associated with increased future left ventricular mass. While only 5 papers related RFs to future cardiac function, all RFs were positively associated with worse future diastolic function.</p><p><strong>Conclusions: </strong>BP, BMI and glycaemic control measures in childhood, adolescence and early adulthood and subsequent longitudinal trajectories of BP and BMI are predictive of future abnormalities in cardiac structure and function. Lifetime RF history should be used to inform clinical practice. Further research is required to enable the identification of any sensitive periods in the life course to enable prevention when it is most likely to be effective.</p>","PeriodicalId":91107,"journal":{"name":"Journal of cardiology and therapeutics","volume":"2 2","pages":"78-87"},"PeriodicalIF":0.0,"publicationDate":"2014-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4902124/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34462673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}