Miriam Kwarteng-Siaw, Vivian Paintsil, Catherine Korankye Toboh, Amma Owusu-Ansah, Nancy S Green
{"title":"Assessment of Transition Readiness in Adolescents with Sickle Cell Disease and their Caretakers, A single institution experience.","authors":"Miriam Kwarteng-Siaw, Vivian Paintsil, Catherine Korankye Toboh, Amma Owusu-Ansah, Nancy S Green","doi":"10.17554/j.issn.2409-3548.2017.03.47","DOIUrl":"https://doi.org/10.17554/j.issn.2409-3548.2017.03.47","url":null,"abstract":"<p><strong>Aim: </strong>Sickle Cell Disease (SCD) is associated with high child mortality and birth incidence in sub-Saharan Africa. Improved SCD medical services in Ghana aims to enhance survival into adulthood, creating emerging need for transition from pediatric to adult care. Anticipating transition for adolescents with SCD, we sought to understand patient and caretaker perspectives on transition to adult care within Ghana.</p><p><strong>Materials and methods: </strong>Structured interviews were conducted with a sample of patients ages 12-15 years and accompanying adults at Ghana's Komfo Anokye Teaching Hospital Sickle Cell Clinic (KATH SCC) covering four areas: SCD medical knowledge, symptom self-management, psychosocial impact, and transition preparation.</p><p><strong>Results: </strong>In total, 46 children (mean age 13 years) paired with 46 adults were interviewed. Most children and caretakers had some knowledge about SCD and disease management. At least one-third lacked knowledge about SCD as an inherited condition. Youth were significantly more concerned about family burden and social stigmatization than adults. Most were unaware that patients are expected to switch care to adult medical providers by age 15 years, but were willing to transfer if needed.</p><p><strong>Conclusions: </strong>Our clinic-based assessment at KATH SCC identified needs of adolescents and caretakers for education and counseling about disease, self-management, transition, family burden, and stigmatization. These findings provide insights into perspectives and educational gaps of families treated for SCD. Results suggest consideration of transition planning for adolescents with SCD and their caretakers in Ghana. Generalizability of our findings and practical methods to address needs for transition within Africa remain to be tested.</p>","PeriodicalId":91093,"journal":{"name":"International journal of hematology research","volume":"3 1","pages":"171-179"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.17554/j.issn.2409-3548.2017.03.47","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36335713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Young Kim, Brent T Xia, Alex L Chang, Timothy A Pritts
{"title":"Role of Leukoreduction of Packed Red Blood Cell Units in Trauma Patients: A Review.","authors":"Young Kim, Brent T Xia, Alex L Chang, Timothy A Pritts","doi":"10.17554/j.issn.2409-3548.2016.02.31","DOIUrl":"https://doi.org/10.17554/j.issn.2409-3548.2016.02.31","url":null,"abstract":"<p><p>Hemorrhagic shock is a leading cause of mortality within the trauma population, and blood transfusion is the standard of care. Leukoreduction filters remove donor leukocytes prior to transfusion of blood products. While the benefits of leukocyte depletion are well documented in scientific literature, these benefits do not translate directly to the clinical setting. This review summarizes current research regarding leukoreduction in the clinical arena, as well as studies performed exclusively in the trauma population.</p>","PeriodicalId":91093,"journal":{"name":"International journal of hematology research","volume":"2 2","pages":"124-129"},"PeriodicalIF":0.0,"publicationDate":"2016-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.17554/j.issn.2409-3548.2016.02.31","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35017650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Role of Macrophage in the Pathogenesis of Brain Arteriovenous Malformation.","authors":"Li Ma, Yi Guo, Yuan-Li Zhao, Hua Su","doi":"10.17554/j.issn.2409-3548.2015.01.12","DOIUrl":"https://doi.org/10.17554/j.issn.2409-3548.2015.01.12","url":null,"abstract":"<p><p>Brain arteriovenous malformation (BAVM) is an important risk factor for intracranial hemorrhage, especially in children and young adults. Inflammation has been implicated in BAVM lesion progression. Among various inflammatory components, macrophage is one of the major inflammatory cells present in human ruptured and unruptured BAVM and in the BAVM lesions of animal models. The role of macrophage in BAVM pathogenesis is not fully understood. In this review, we summarize recent studies on macrophages and introduce a non-invasive imaging protocol as a potential tool for detecting macrophage in BAVM and predicting the risk of BAVM rupture.</p>","PeriodicalId":91093,"journal":{"name":"International journal of hematology research","volume":"1 2","pages":"52-56"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4610371/pdf/nihms698657.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34112613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}