{"title":"Modeling migration in cell colonies in two and three dimensional substrates with varying stiffnesses","authors":"M. Dudaie, D. Weihs, F. Vermolen, A. Gefen","doi":"10.1186/S40482-015-0005-9","DOIUrl":"https://doi.org/10.1186/S40482-015-0005-9","url":null,"abstract":"","PeriodicalId":91084,"journal":{"name":"In silico cell and tissue science","volume":"2 1","pages":"1-14"},"PeriodicalIF":0.0,"publicationDate":"2015-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/S40482-015-0005-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65886806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aurélie Carlier, Johan Lammens, Hans Van Oosterwyck, Liesbet Geris
{"title":"Computational modeling of bone fracture non-unions: four clinically relevant case studies.","authors":"Aurélie Carlier, Johan Lammens, Hans Van Oosterwyck, Liesbet Geris","doi":"10.1186/s40482-015-0004-x","DOIUrl":"10.1186/s40482-015-0004-x","url":null,"abstract":"<p><p>The human skeleton has a remarkable regeneration capacity. Nevertheless, 5-10 % of the bone fractures fails to heal and develops into a non-union which is a challenging orthopedic complication requiring complex and expensive treatment. This review paper will discuss four different computational models, each capturing a particular clinical case of non-union: non-union induced by reaming of the marrow canal and periosteal stripping, non-union due to a large interfragmentary gap, non-union due to a genetic disorder [i.e. NF1 related congenital pseudoarthrosis of the tibia (CPT)] and non-union due to mechanical overload. Together, the four computational models are able to capture the etiology of a wide range of fracture non-union types and design novel treatment strategies thereof. Further research is required to corroborate the computational models in both animal and human settings and translate them from bench to bed side.</p>","PeriodicalId":91084,"journal":{"name":"In silico cell and tissue science","volume":"2 1","pages":"1"},"PeriodicalIF":0.0,"publicationDate":"2015-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4684906/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65886796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Etiology of Keratoconus: proposed biomechanical pathogenesis","authors":"R. Asher, A. Gefen, E. Moisseiev, D. Varssano","doi":"10.1186/2196-050X-1-3","DOIUrl":"https://doi.org/10.1186/2196-050X-1-3","url":null,"abstract":"","PeriodicalId":91084,"journal":{"name":"In silico cell and tissue science","volume":"1 1","pages":"1-9"},"PeriodicalIF":0.0,"publicationDate":"2014-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/2196-050X-1-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66148945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Carlos Borau, William J Polacheck, Roger D Kamm, José Manuel García-Aznar
{"title":"Probabilistic Voxel-Fe model for single cell motility in 3D.","authors":"Carlos Borau, William J Polacheck, Roger D Kamm, José Manuel García-Aznar","doi":"10.1186/2196-050X-1-2","DOIUrl":"https://doi.org/10.1186/2196-050X-1-2","url":null,"abstract":"<p><strong>Background: </strong>Cells respond to a variety of external stimuli regulated by the environment conditions. Mechanical, chemical and biological factors are of great interest and have been deeply studied. Furthermore, mathematical and computational models have been rapidly growing over the past few years, permitting researches to run complex scenarios saving time and resources. Usually these models focus on specific features of cell migration, making them only suitable to study restricted phenomena.</p><p><strong>Methods: </strong>Here we present a versatile finite element (FE) cell-scale 3D migration model based on probabilities depending in turn on ECM mechanical properties, chemical, fluid and boundary conditions.</p><p><strong>Results: </strong>With this approach we are able to capture important outcomes of cell migration such as: velocities, trajectories, cell shape and aspect ratio, cell stress or ECM displacements.</p><p><strong>Conclusions: </strong>The modular form of the model will allow us to constantly update and redefine it as advancements are made in clarifying how cellular events take place.</p>","PeriodicalId":91084,"journal":{"name":"In silico cell and tissue science","volume":"1 ","pages":"2"},"PeriodicalIF":0.0,"publicationDate":"2014-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/2196-050X-1-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33937679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}