Runhua Liu, Silin Li, Wei-Hsiung Yang, Lizhong Wang
{"title":"IPEX Syndrome, FOXP3 and Cancer.","authors":"Runhua Liu, Silin Li, Wei-Hsiung Yang, Lizhong Wang","doi":"10.13188/2380-6036.1000001","DOIUrl":"https://doi.org/10.13188/2380-6036.1000001","url":null,"abstract":"<p><p>In this review, we introduce the IPEX syndrome and its relationship with germline mutations of the FOXP3 gene. We then describe the multiple functional roles of FOXP3 in regulatory T cells and epithelial cells as well as in IPEX syndrome and tumor progression. Potential mechanisms of <i>FOXP3</i> inactivation and transcriptional regulation are discussed with recent advances. Finally, we point out current issues and a potential FOXP3-mediated therapeutic strategy as well as the reactivation of FOXP3 in patients with IPEX syndrome and cancer.</p>","PeriodicalId":90911,"journal":{"name":"Journal of syndromes","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2013-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4383293/pdf/nihms-578696.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33193034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}