International journal on advances in life sciences最新文献

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A Virtual Patient Simulator Based on Human Connectome and 7 T MRI for Deep Brain Stimulation. 基于人体连接组和7t MRI的深部脑刺激虚拟患者模拟器。
Giorgio Bonmassar, Leonardo M Angelone, Nikos Makris
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引用次数: 0
Potential Antibacterial Targets in Bacterial Central Metabolism. 细菌中枢代谢的潜在抗菌靶点。
Nichole Louise Haag, Kimberly Kay Velk, Chun Wu
{"title":"Potential Antibacterial Targets in Bacterial Central Metabolism.","authors":"Nichole Louise Haag,&nbsp;Kimberly Kay Velk,&nbsp;Chun Wu","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The emerging antibiotic resistant bacteria and their abilities for rapid evolution have pushed the need to explore alternative antibiotics less prone to drug resistance. In this study, we employed methicillin/multidrug-resistant <i>Staphylococcus aureus</i> (MRSA) as a model bacterial system to initiate novel antibiotic development. An <i>in silico</i> identification of drug targets in <i>MRSA</i> 252 strain and <i>MRSA</i> Mu50 strain respectively was described. The identified potential targets were classified according to their known or putative functions. We discovered that a class of essential non-human homologous, central metabolic enzymes falls into the scope of potential drug targets for two reasons: 1) the identified targets either do not have human counterparts or use alternative catalytic mechanisms. Based on major differences in active site structure and catalytic mechanism, an inhibitor of such a bacterial enzyme can be designed which will not inhibit its human cousin. 2) attacking bacterial energy-making machinery bypasses the usual drug resistance sites, paving the road to multi-faceted approaches to combat antibiotic resistance.</p>","PeriodicalId":90872,"journal":{"name":"International journal on advances in life sciences","volume":"4 1-2","pages":"21-32"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3800682/pdf/nihms-474178.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40260749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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