Dobutsu iden ikushu kenkyu = Journal of animal genetics最新文献

筛选
英文 中文
巻頭言 卷首语
Dobutsu iden ikushu kenkyu = Journal of animal genetics Pub Date : 2023-01-15 DOI: 10.5924/abgri.51.1
{"title":"巻頭言","authors":"","doi":"10.5924/abgri.51.1","DOIUrl":"https://doi.org/10.5924/abgri.51.1","url":null,"abstract":"","PeriodicalId":90818,"journal":{"name":"Dobutsu iden ikushu kenkyu = Journal of animal genetics","volume":"89 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135789171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inherited retinal diseases in dogs: advances in gene/mutation discovery. 狗的遗传性视网膜疾病:发现基因/突变的进展。
Dobutsu iden ikushu kenkyu = Journal of animal genetics Pub Date : 2014-01-01 DOI: 10.5924/abgri.42.79
Keiko Miyadera
{"title":"Inherited retinal diseases in dogs: advances in gene/mutation discovery.","authors":"Keiko Miyadera","doi":"10.5924/abgri.42.79","DOIUrl":"10.5924/abgri.42.79","url":null,"abstract":"<p><p>1. Inherited retinal diseases (RDs) are vision-threatening conditions affecting humans as well as many domestic animals. Through many years of clinical studies of the domestic dog population, a wide array of RDs has been phenotypically characterized. Extensive effort to map the causative gene and to identify the underlying mutation followed. Through candidate gene, linkage analysis, genome-wide association studies, and more recently, by means of next-generation sequencing, as many as 31 mutations in 24 genes have been identified as the underlying cause for canine RDs. Most of these genes have been associated with human RDs providing opportunities to study their roles in the disease pathogenesis and in normal visual function. The canine model has also contributed in developing new treatments such as gene therapy which has been clinically applied to human patients. Meanwhile, with increasing knowledge of the molecular architecture of RDs in different subpopulations of dogs, the conventional understanding of RDs as a simple monogenic disease is beginning to change. Emerging evidence of modifiers that alters the disease outcome is complicating the interpretation of DNA tests. In this review, advances in the gene/mutation discovery approaches and the emerging genetic complexity of canine RDs are discussed.</p>","PeriodicalId":90818,"journal":{"name":"Dobutsu iden ikushu kenkyu = Journal of animal genetics","volume":"42 2","pages":"79-89"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4480793/pdf/nihms700467.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33428194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信
小红书