Advances in vascular medicine最新文献

筛选

英文中文

Vascular Aging across the Menopause Transition in Healthy Women. 健康女性绝经期血管老化

Advances in vascular medicine Pub Date : 2014-07-17 DOI: 10.1155/2014/204390

Kerrie L Moreau, Kerry L Hildreth

{"title":"Vascular Aging across the Menopause Transition in Healthy Women.","authors":"Kerrie L Moreau, Kerry L Hildreth","doi":"10.1155/2014/204390","DOIUrl":"https://doi.org/10.1155/2014/204390","url":null,"abstract":"<p><p>Vascular aging, featuring endothelial dysfunction and large artery stiffening, is a major risk factor for developing cardiovascular disease (CVD). In women, vascular aging appears to be accelerated during the menopause transition, particularly around the late perimenopausal period, presumably related to declines in ovarian function and estrogen levels. The mechanisms underlying endothelial dysfunction and large artery stiffening with the menopause transition are not completely understood. Oxidative stress and the proinflammatory cytokine tumor necrosis factor-α contribute to endothelial dysfunction and large artery stiffening in estrogen-deficient postmenopausal women. Habitual endurance exercise attenuates the age-related increase in large artery stiffness in estrogen-deficient postmenopausal women and can reverse arterial stiffening to premenopausal levels in estrogen-replete postmenopausal women. In contrast, estrogen status appears to play a key permissive role in the adaptive response of the endothelium to habitual endurance exercise in that endothelial improvements are absent in estrogen-deficient women but present in estrogen-replete women. We review here the current state of knowledge on the biological defects underlying vascular aging across the menopause transition, with particular focus on potential mechanisms, the role of habitual exercise in preserving vascular health, and key areas for future research.</p>","PeriodicalId":90781,"journal":{"name":"Advances in vascular medicine","volume":"2014 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2014-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/204390","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33312411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 77