Journal of clinical and experimental research in cardiology最新文献

{"title":"His Bundle Pacing: Short Review of Literature and Technical Aspects","authors":"M. S","doi":"10.15744/2394-6504.4.201","DOIUrl":"https://doi.org/10.15744/2394-6504.4.201","url":null,"abstract":"History of pacing has evolved from the primitive state of temporary transvenous pacing by large fixed machine to leadless modern technology. The pacing site has also been changed from traditional right ventricular apex to various other sites. The concept behind such experient was due to several complications in the long term from traditional Right Ventricular Apical Pacing (RVAP). The His Bundle pacing results in conduction and contraction similar to and and more often called physiological pacing. This mini review describes short history of evolution of concept of His Bundle pacing and its technical aspects of successful implantation.","PeriodicalId":90582,"journal":{"name":"Journal of clinical and experimental research in cardiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86784631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study of Enzymes in Myocardial Infarction","authors":"S. Yeluri","doi":"10.15744/2394-6504.4.106","DOIUrl":"https://doi.org/10.15744/2394-6504.4.106","url":null,"abstract":"The term Myocardial infarction signifies sudden necrosis or death of a portion of cardiac muscle due to inadequate blood supply [1]. Myocardial infarction results from prolonged myocardial coronary thrombus at the site of a pre-existing atherosclerotic stenosis [2]. The major cause of acute myocardial infarction is atherosclerosis [3]. It is three to four times more frequent among men than women [4].","PeriodicalId":90582,"journal":{"name":"Journal of clinical and experimental research in cardiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88703619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the Mandibular Incisive Canal by Panoramic Radiography and Cone-Beam Computed Tomography","authors":"P. Tauber, Virginia Mansilla, P. Brugada, Sara S Sánchez P, S. Honoré, M. Elizari, Sergio Chain Molina, Félix A. Albano, Ricardo R. Corbalán, Federico Figueroa Castellanos, Damian Alzugaray Bioeng","doi":"10.15744/2394-6504.4.101","DOIUrl":"https://doi.org/10.15744/2394-6504.4.101","url":null,"abstract":"Background: Radiofrequency ablation (RFA) in Brugada syndrome (BrS) has been performed both endocardially and epicardially. The substrate in BrS is thus unclear. Objectives: To investigate the functional endocardial substrate and its correlation with clinical, electrophysiological and ECG findings in order to guide an endocardial ablation. Methods: Thirteen patients (38.7±12.3 years old) with spontaneous type 1 ECG BrS pattern, inducible VF with programmed ventricular stimulation (PVS) and syncope without prodromes were enrolled. Before to endocardial mapping the patients underwent flecainide testing with the purpose of measuring the greatest ST-segment elevation for to be correlated with the size and location of substrate in the electro-anatomic map. Patients underwent endocardial bipolar and electro-anatomic mapping with the purpose of identify areas of abnormal electrograms (EGMs) as target for RFA and determine the location and size of the substrate. Results: When the greatest ST-segment elevation was in the 3rd intercostal space (ICS), the substrate was located upper in the longitudinal plane of the right ventricular outflow tract (RVOT) and a greatest ST-segment elevation in 4th ICS correspond with a location of substrate in lower region of longitudinal plane of RVOT. A QRS complex widening on its initial and final part, with prolonged transmural and regional depolarization time of RVOT corresponded to the substrate locateded in the anterior-lateral region of RVOT. A QRS complex widening rightwards and only prolonged transmural depolarization time corresponded with a substrate located in the anterior, anterior-septal or septal region of RVOT. RFA of endocardial substrate suppressed the inducibility and ECG BrS pattern during 34.7±15.5 months. After RFA, flecainide testing confirmed elimination of the ECG BrS pattern. Endocardial biopsy showed a correlation between functional and ultrastructural alterations in two patients.","PeriodicalId":90582,"journal":{"name":"Journal of clinical and experimental research in cardiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81891999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bernoulli Equation in the Mitral Valve of Heart","authors":"Karvandi M, Ranjbar S","doi":"10.15744/2394-6504.4.102","DOIUrl":"https://doi.org/10.15744/2394-6504.4.102","url":null,"abstract":"Background: The mechanics of the mitral valve leaflet as a nonlinear, inelastic and anisotropic soft tissue results from an integrated response of many mathematical/physical indexes’ that illustrate the tissue. Objectives: The objective of this paper is to study and give an algorithm for the mechanisms of mitral valve of the heart based on mathematical techniques and Bernoulli’s equation. Methods and Results: Utilizing mathematical techniques and Bernoulli’s equation, we can make a geometrical modeling of the mitral valve leaflets and give available and valuable clinical benefit information of the Mitral valve behaviors for physician. Echocardiography was performed on healthy volunteers. Data evaluated included: velocity (radial, longitudinal, rotational and vector point), displacement (longitudinal and rotational), strain rate (longitudinal and circumferential) and strain (radial, longitudinal and circumferential) of all leaflet segments. Using these data, force vectors of myocardial samples and a new formula that was provided by Bernoulli equation, we were able to see what’s happening around the mitral valve of heart. All data were estimated/run by MATLAB software.","PeriodicalId":90582,"journal":{"name":"Journal of clinical and experimental research in cardiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88880244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Myocardial Revascularization on the Range of Joint Motion of the Superior and Inferior Members","authors":"Li Al, De Lima Asf, Silva Rds, Borges Dl, G. G, Guimaraes Ar, Esquivel Ms, Mascarenhas Hdc","doi":"10.15744/2394-6504.4.105","DOIUrl":"https://doi.org/10.15744/2394-6504.4.105","url":null,"abstract":"Introduction: The surgical procedure for myocardial revascularization (MRI) may compromise chest stability, compliance and range of motion (ROM) of the shoulder joint due to sternotomy and knee joint due to saphenectomy. Objective: To evaluate the impact of myocardial revascularization surgery on upper and lower limb ROM Methodology: This is a prospective cohort study, performed with a group of patients submitted to cardiac surgery. In the preoperative period the ROM was evaluated through a goniometer, for flexion, horizontal abduction and vertical abduction of the right and left shoulder, as well as evaluation of the flexo-extension movement of the right knee. On the day of discharge from the Intensive Care Unit, the patients were reassessed. Results:Twenty patients were evaluated during the time of the study. The majority were men 14 (70%), with a mean age of 60 ± 10 years. Regarding ROM, it was verified that all the movements presented a significant reduction in the postoperative period. The right shoulder flexion (75 ± 11ºvs66 ± 8º, p = 0, p <0.01), right shoulder abduction (155 ± 17º vs127 ± 22º, p < (P = 0.02), right vertical abduction (142 ± 24º vs117 ± 22º, p <0.01), left vertical abduction (142 ± 24º vs121 ± 22º, p = 0), left horizontal abduction (79 ± 9º vs70 ± 5º, p=0,02), Knee flexion (100 ± 14º vs75 ± 19º, p <0.01) and knee extension (94 ± 13º vs79 ± 15º, p <0.01). Conclusion: It can be concluded that the surgery promote reduction of the range of joint motion in this sample of patients submitted to myocardial revascularization.","PeriodicalId":90582,"journal":{"name":"Journal of clinical and experimental research in cardiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86360902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health-Related Quality of life of Complete versus Infarct artery-only Percutaneous Coronary Revascularization in Multi-vessel Disease with ST-Segment Elevation Myocardial Infarction","authors":"Jayaraj Jc","doi":"10.15744/2394-6504.4.104","DOIUrl":"https://doi.org/10.15744/2394-6504.4.104","url":null,"abstract":"Objective: The aim of this study was to evaluate the health-related quality of life (HRQoL) as measured by the EQ-5D (European quality of life-5 dimensions) self-report questionnaire in patients treated with complete revascularization versus infarct artery-only revascularization at index admission. Background: The revascularization strategies for multivessel disease while undergoing primary percutaneous coronary intervention (P-PCI) on HRQoL is uncertain. Methods and Results: STEMI patients with multivessel disease underwent either complete or between April 1, 2012, and March 31, 2014, were subdivided into those who underwent complete revascularization (n = 133) or infarct-related artery (IRA)-only revascularization (n = 139) at index admission. The EQ-5D assessed mobility, self-care, usual activity, pain or discomfort, and anxiety or depression. Patient groups were differed at baseline by gender and prevalence of heart failure. At 2-year follow-up, both mean (±SD) EQ-VAS and EQ-5D utility scores were lower for patients who underwent complete revascularization versus infarct artery-only revascularization (60.00 (±18.8) vs. 59.03 (±16.9), P < 0.03, and 0.68 (±0.02) vs. 0.54 (±0.02), P<0.004, respectively). Conclusion: The clinically significant improvement in QoL was seen in the complete revascularization group compared with treating only the IRA at 24 months.","PeriodicalId":90582,"journal":{"name":"Journal of clinical and experimental research in cardiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86568003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Subclinical Levt Ventricular Diastolic Dysfunction in Patient with Metabolic Syndrome in West Region of the Republic of Macedonia","authors":"Jani Y","doi":"10.15744/2394-6504.4.103","DOIUrl":"https://doi.org/10.15744/2394-6504.4.103","url":null,"abstract":"Background: Metabolic Syndrome (MetS) has been associated with subclinical changes in cardiac structure and function, including left ventricular diastolic dysfunction (LVDD) and is strong risk factors for the future development of clinical heart failure, and specifically increases the risk of heart failure with preserved ejection fraction. To date, the evidence on the prevalence of subclinical LVDD in patient with MetS and relation to components of the MetS, in west region of the Republic of Macedonia are scarce. Objective: We sought to determine the prevalence of subclinical LVDD and relation to components of the MetS, in patient with MetS in our region. Methods: We conducted a multicenter observational cross-sectional study. Recruited were 550 consecutive participants,450 with MetS (mean age 50 years,49% women) and 100 controls (no risk factors for MetS; mean 51 years,57% women) , who attended outpatient visits at general cardiology Health Care Clinics in 6 town on western region Republic of Macedonia, during 1 calendar year. Pertcipans underwent echocardiography with tissue Doppler imaging. Results: Participants with MetS, have significantly increased frequency of subclical LVDD grade 1, in comparation with participants without MetS. (39, 7% vs. 6%, p=0.0005). The overall frequency of subclinical LVDD grade 1, in participants with MetS, was 39, 7%; p=0.0005). Subjects with MetS also had worse measures of diastolic function, including: higher Lev Atrial Volum index {(LAVI), (p=0.00), Lower E/A ratio (p=0.00),lower mean e’(p=0.00) and lower E/ e’ ratio(p=0.00), increased Deceleratio time {(DT),(p=0.00)} and Isovolumetric Relaxation time{(IVRT), (p=0.00). Overall, participants with subclinical LVDD, had a worse cardiovascular risk factor profile, including: higher BMI (p=0.001), higher blood pressure{(BP) (p=0.003)}, elevated Weist circumference{(WC)(p=0.001)} and dyslipidemia (p=0.000) in comparation with participants with normal diastolic function. Also, participants with subclinical LVDD,have more risk factors for MetS than participants with normal diastolic function (p=0.002). There was a significant assotiation between subclinical LVDD and: Age (OR=1.108; 95% CI 1.051 -1.168), Females (OR=3.633; 95% CI2.439-5.413), BMI (OR=7.474; 95% CI 4.881-11.443), control of BP (OR=1.763; 95% CI 1.204-2.580) and number of MetS risk factors (OR= 3.609; 95% CI 2.054-6.340). Conclusion: The prevalence of subclinical LVDD in the patients with MetS, in abscence of coronary disease and other well know heart disease, is considerablye high in western region of the Republic of Macedonia and seem to be significantly associated with age, gender, BMI, Levt Ventricular mass index (LVMI) and number of risk factors for MetS.","PeriodicalId":90582,"journal":{"name":"Journal of clinical and experimental research in cardiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86015325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Use of Cardiac Resynchronization Therapy in Cancer Patients with Heart Failure.","authors":"Anecita P Fadol,&nbsp;Elie Mouhayar,&nbsp;Cielito C Reyes-Gibby","doi":"10.15744/2394-6504.3.105","DOIUrl":"https://doi.org/10.15744/2394-6504.3.105","url":null,"abstract":"<p><strong>Objectives: </strong>Investigate the use of cardiac resynchronization therapy (CRT) in cancer patients with heart failure (HF); assess factors associated with ischemic and non-ischemic HF.</p><p><strong>Background: </strong>Many newer cancer therapies are cardiotoxic; thus, the incidence of HF has been increasing in this high-risk patient population. CRT has beneficial effects on morbidity, mortality, and left ventricular function in patients with non-ischemic cardiomyopathy, yet cancer patients and survivors who develop severe HF and are eligible for CRT often do not receive it.</p><p><strong>Methods: </strong>Review of 2 years of echocardiography and electrocardiography data from cancer patients.</p><p><strong>Results: </strong>Of 272 patients meeting inclusion criteria for CRT placement (LVEF ≤35%, QRS duration ≥120 ms), 131 (48.2%) had HF with ischemic etiology and 141 (51.8%) had HF with non-ischemic etiology. Most patients had solid tumors, including breast, lung, sarcoma, and lymphoma (73.2%, n=199). Only 21.3% (58/272; 27 ischemic; 31 non-ischemic) underwent CRT placement, who were mostly women and those with solid tumors. Non-ischemic HF was significantly associated with younger age (<65 years) (OR=0.91; 95% CI=0.87-0.95) and female sex (OR=2.5; 95% CI=1.1-6.0). As expected, ischemic HF was significantly associated with history of myocardial infarction, diabetes, and cardiovascular disease.</p><p><strong>Conclusions: </strong>CRT is underutilized in cancer patients with HF. Most of the cancer patients who did not receive CRT had non-ischemic HF secondary to chemotherapy. CRT may be less utilized in those patients due to shortened life expectancy, yet evidence suggests that CRT has beneficial effects on morbidity, mortality, and left ventricular function. Its use may improve patient quality of life and allow oncologists to continue cancer treatments that could prolong survival.</p>","PeriodicalId":90582,"journal":{"name":"Journal of clinical and experimental research in cardiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6022845/pdf/nihms938415.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36274980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acculturation and Subclinical Atherosclerosis among U.S. South Asians: Findings from the MASALA study.","authors":"Kanaya Am, Ewing Sk, Vittinghoff E, Herrington D, Tegeler C, Mills C, Kandula Nr","doi":"10.15744/2394-6504.1.102","DOIUrl":"https://doi.org/10.15744/2394-6504.1.102","url":null,"abstract":"OBJECTIVE\u0000Longer duration of residence among immigrants to the United States, a proxy measure of acculturation, has been associated with higher subclinical atherosclerosis. South Asian immigrants are the second fastest growing immigrant group in the U.S. but little is known about the effects of acculturation with atherosclerosis in this high cardiovascular risk population.\u0000\u0000\u0000METHODS\u0000We conducted a cross-sectional analysis using data from a community-based cohort called the Mediators of Atherosclerosis in South Asians Living in America (MASALA) study. Participants (n=900) were between ages of 40-84 years and had no existing cardiovascular disease. We developed a multi-dimensional measure of acculturation in South Asians, called traditional cultural beliefs, and measured other proxy measures of acculturation to determine whether they were associated with higher levels of subclinical atherosclerosis after controlling for socioeconomic, behavior/lifestyle, and cardiovascular risk factors.\u0000\u0000\u0000RESULTS\u0000Mean duration of residence in the U.S. was 27±11 years and tertiles of strength of traditional cultural beliefs were examined. Longer duration of U.S. residence was associated with higher levels of coronary artery calcium even after adjustment for covariates and lifestyle mediators. The novel measure of strength of traditional cultural beliefs was associated with lower common carotid intima media thickness among those with moderate traditional beliefs only.\u0000\u0000\u0000CONCLUSIONS\u0000These findings support the need for better conceptualization and measurement of how migration influences cultural beliefs and practices, and their subsequent influence on health behaviors and cardiovascular disease risk.","PeriodicalId":90582,"journal":{"name":"Journal of clinical and experimental research in cardiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78578084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acculturation and Subclinical Atherosclerosis among U.S. South Asians: Findings from the MASALA study.","authors":"Am Kanaya,&nbsp;Sk Ewing,&nbsp;E Vittinghoff,&nbsp;D Herrington,&nbsp;C Tegeler,&nbsp;C Mills,&nbsp;Nr Kandula","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>Longer duration of residence among immigrants to the United States, a proxy measure of acculturation, has been associated with higher subclinical atherosclerosis. South Asian immigrants are the second fastest growing immigrant group in the U.S. but little is known about the effects of acculturation with atherosclerosis in this high cardiovascular risk population.</p><p><strong>Methods: </strong>We conducted a cross-sectional analysis using data from a community-based cohort called the Mediators of Atherosclerosis in South Asians Living in America (MASALA) study. Participants (n=900) were between ages of 40-84 years and had no existing cardiovascular disease. We developed a multi-dimensional measure of acculturation in South Asians, called traditional cultural beliefs, and measured other proxy measures of acculturation to determine whether they were associated with higher levels of subclinical atherosclerosis after controlling for socioeconomic, behavior/lifestyle, and cardiovascular risk factors.</p><p><strong>Results: </strong>Mean duration of residence in the U.S. was 27±11 years and tertiles of strength of traditional cultural beliefs were examined. Longer duration of U.S. residence was associated with higher levels of coronary artery calcium even after adjustment for covariates and lifestyle mediators. The novel measure of strength of traditional cultural beliefs was associated with lower common carotid intima media thickness among those with moderate traditional beliefs only.</p><p><strong>Conclusions: </strong>These findings support the need for better conceptualization and measurement of how migration influences cultural beliefs and practices, and their subsequent influence on health behaviors and cardiovascular disease risk.</p>","PeriodicalId":90582,"journal":{"name":"Journal of clinical and experimental research in cardiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4283837/pdf/nihms634508.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32958514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}