Jacobs journal of radiation oncology最新文献

{"title":"Gold Nanoparticles for Radiation Enhancement <i>in Vivo</i>.","authors":"Samana Shrestha,&nbsp;Leon N Cooper,&nbsp;Oleg A Andreev,&nbsp;Yana K Reshetnyak,&nbsp;Michael P Antosh","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Enhancing the effect of radiation on tumors would be a significant improvement in radiation therapy. With radiation enhancement, less radiation could be used to achieve the same goals, lessening damage to healthy tissue and lessening side effects. Gold nanoparticles are a promising method for achieving this enhancement, particularly when the gold nanoparticles are targeted to cancer. This literature review discusses the properties of gold nanoparticles as well as existing <i>in vivo</i> radiation enhancement results using both targeted and non-targeted gold nanoparticles.</p>","PeriodicalId":90567,"journal":{"name":"Jacobs journal of radiation oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5513501/pdf/nihms838256.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35184450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interobserver and intermodality variability in GTV delineation on simulation CT, FDG-PET, and MR Images of Head and Neck Cancer.","authors":"Carryn M Anderson,&nbsp;Wenqing Sun,&nbsp;John M Buatti,&nbsp;Joan E Maley,&nbsp;Bruno Policeni,&nbsp;Sarah L Mott,&nbsp;John E Bayouth","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Purpose: </strong>To compare the interobserver and intermodality differences in image-based identification of head and neck primary site gross tumor volumes (GTV). Modalities compared include: contrast-enhanced CT, F-18 fluorodeoxyglucose positron emission tomography (PET/CT) and contrast-enhanced MRI.</p><p><strong>Methods and materials: </strong>Fourteen patients were simulated after immobilization for all 3 imaging modalities (CT, PET/CT, MRI). Three radiation oncologists (RO) contoured GTVs as seen on each modality. The GTV was contoured first on the contrast-enhanced CT (considered the standard), then on PET/CT, and finally on post-contrast T1 MRI. Interobserver and intermodality variability were analyzed by volume, intersection, union, and volume overlap ratio (VOR).</p><p><strong>Results: </strong>Analysis of RO contours revealed the average volume for CT-, PET/CT-, and MRI-derived GTVs were 45cc, 35cc and 49cc, respectively. In 93% of cases PET/CT-derived GTVs had the smallest volume and in 57% of cases MRI-derived GTVs had the largest volume. CT showed the largest variation in target definition (standard deviation amongst observers 35%) compared to PET/CT (28%) and MRI (27%). The VOR was largest (indicating greatest interobserver agreement) in PET/CT (46%), followed by MRI (36%), followed by CT (34%). For each observer, the least agreement in GTV definition occurred between MRI & PET/CT (average VOR = 41%), compared to CT & PET/CT (48%) and CT & MRI (47%).</p><p><strong>Conclusions: </strong>A nonsignificant interobserver difference in GTVs for each modality was seen. Among three modalities, CT was least consistent, while PET/CT-derived GTVs had the smallest volumes and were most consistent. MRI combined with PET/CT provided the least agreement in GTVs generated. The significance of these differences for head & neck cancer is important to explore as we move to volume-based treatment planning based on multi-modality imaging as a standard method for treatment delivery.</p>","PeriodicalId":90567,"journal":{"name":"Jacobs journal of radiation oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4283948/pdf/nihms647804.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32960096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Perspective on Chromosomal Double Strand Break Markers in Mammalian Cells.","authors":"Haibo Wang,&nbsp;Sanjay Adhikari,&nbsp;Brian E Butler,&nbsp;Tej K Pandita,&nbsp;Sankar Mitra,&nbsp;Muralidhar L Hegde","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":90567,"journal":{"name":"Jacobs journal of radiation oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4299656/pdf/nihms645301.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32997463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}