Enliven. Challenges in cancer detection and therapy最新文献

{"title":"A Novel Pathway that Links Caveolin-1 Down-Regulation to BRCA1 Dysfunction in Serous Epithelial Ovarian Cancer Cells.","authors":"Jingyao Xu,&nbsp;Stephanie Agyemang,&nbsp;Yunlong Qin,&nbsp;Kartik Aysola,&nbsp;Mercedes Giles,&nbsp;Gabriela Oprea,&nbsp;Ruth M O'Regan,&nbsp;Edward E Partridge,&nbsp;Sandra Harris-Hooker,&nbsp;Valarie Montgomery Rice,&nbsp;E Shyam P Reddy,&nbsp;Veena N Rao","doi":"10.18650/2376-046x.11004","DOIUrl":"https://doi.org/10.18650/2376-046x.11004","url":null,"abstract":"<p><p>Ovarian cancer is the second most common gynecological cancer and the five-year survival rate is only about 40%. High-grade serous carcinoma is the pre-dominant histotype associated with hereditary ovarian cancer and women with inherited mutations in BRCA1 have a lifetime risk of 40-60%. BRCA1 and its isoform BRCA1a are multifunctional proteins that are the most evolutionary conserved of all the other splice variants. Our group has previously reported that BRCA1/1a proteins, unlike K109R and C61G mutants, suppress growth of ovarian cancer cells by tethering Ubc9. In this study we found wild type BRCA1/1a proteins to induce expression of caveolin-1, a tumor suppressor in BRCA1-mutant serous epithelial ovarian cancer (SEOC) cells by immunofluorescence analysis. The K109R and C61G disease associated mutant BRCA1 proteins that do not bind Ubc9 were not as efficient in up-regulation of caveolin-1 expression in SEOC cells. Additionally, immunofluorescence analysis showed BRCA1/1a proteins to induce redistribution of Caveolin-1 from cytoplasm and nucleus to the cell membrane. This is the first study demonstrating the physiological link between loss of Ubc9 binding, loss of growth suppression and loss of Caveolin-1 induction of disease-associated mutant BRCA1 proteins in SEOC cells. Decreased Caveolin-1 expression combined with elevated Ubc9 expression can in the future be used as an early biomarker for BRCA1 mutant SEOC.</p>","PeriodicalId":90493,"journal":{"name":"Enliven. Challenges in cancer detection and therapy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4292936/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32980386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Country Cancer Report.","authors":"Tan Xu,&nbsp;Lucky Giroh,&nbsp;Tong Yu,&nbsp;Wenjie Sun","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":90493,"journal":{"name":"Enliven. Challenges in cancer detection and therapy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4327827/pdf/nihms-652985.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33058170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Country Cancer Report.","authors":"Tan Xu, Lucky Giroh, Tong Yu, Wenjie Sun","doi":"10.18650/2376-046x.11006","DOIUrl":"https://doi.org/10.18650/2376-046x.11006","url":null,"abstract":"Cancer is currently an important public health issue for Chinese government. Statistically cancer is rated as the leading cause of death and with high disease burden in China [1]. According to the data from the government, there are 3.5 million new cancer cases ever year in China. Several reasons could explain the growing numbers of cancer incidences. First of all, China aging population contributes to increasing cancer prevalence. For example, National Bureau of Statistics of China of 2010 showed that the people aged 65 year or above constitutes 8.87% of china population in 2010. Moreover, environmental risk factors also associated with the cancer [2]. In recent years, the worse environmental accompany with rapidly increased cancer incidence and mortality in China. The new challenge is correlating environmental pollution with cancer. It is worrisome to the Chinese. Proven this may be difficult, this may be due to lack of substantiating data and lack of transparency in the part of government about environmental concerns and related data. For example, although ambient PM2.5 and PM10 pollutions are prospectively associated with a significantly increased risk of lung cancer mortality [3,4], it is difficult to evaluate the attribute risk factors of PM2.5 due to lacking of the such pollution data. Of noted, the government begins to share PM2.5 data with public since 2012. However, among the correlation of cancer with types of pollution with respect to air, water and soil, the pollution from the soil are more related with cancer cluster. The environment ministry announced that 3.33 million hectares of cropland—2.5% of China's arable land—is too contaminated to grow food safely, according to a national soil survey conducted from 2006 to 2010 [5]. Previous studies reported the rice, a staple food in china, in the market was contained by the heavy metals including cadmium [6], and arsenic [7]. Both of those heavy metals are carcinogenesis. Hence, the economic development accompany with pollution, especially those soil contamination. Then the products from those contaminated soil, which could include carcinogenesis, evenly consumed by the people. This could be an explanation for the cluster phenomena of cancer in some area in China. Recently, Chinese authorities have acknowledged the existence of so-called “cancer villages” in a new report according to multiple media outlets. This could be a signal to show Chinese government start to concern about the huge cancer rate. Likewise, individuals show more concern on cancer therapy than prevention or control. Chinese believe the traditional medicine had special effect on cancer. Hence, some “natural therapy” is very popular among Chinese cancer patients. Bama, a county in Guangxi Zhuang Autonomous Region, is highlighted for high longevity which is attributed to her unique environment. Recently, it becomes the haven for Chinese cancer patients. Many cancer patients sort her as last hope for natural therapy and","PeriodicalId":90493,"journal":{"name":"Enliven. Challenges in cancer detection and therapy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75453922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}