Clinical and Experimental Medical Sciences最新文献

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A feasibility study of monitoring tongue to palate contacts for instantaneous bio-feedback during speech by electroglottographic equipment 声门电图设备监测舌腭接触瞬间生物反馈的可行性研究
Clinical and Experimental Medical Sciences Pub Date : 2023-01-01 DOI: 10.12988/cems.2023.976
A. Biswas
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引用次数: 0
Prevalence of Hippocampal Sclerosis in a Clinicopathologically Characterized Cohort. 临床病理特征队列中海马硬化的患病率。
Clinical and Experimental Medical Sciences Pub Date : 2013-01-01 DOI: 10.12988/cems.2013.13026
Michael Malek-Ahmadi, Vickram Kahlon, Charles H Adler, Aleksandra Obradov, Kabir Thind, Holly A Shill, Lucia I Sue, John N Caviness, Sandra Jacobson, Marwan N Sabbagh
{"title":"Prevalence of Hippocampal Sclerosis in a Clinicopathologically Characterized Cohort.","authors":"Michael Malek-Ahmadi,&nbsp;Vickram Kahlon,&nbsp;Charles H Adler,&nbsp;Aleksandra Obradov,&nbsp;Kabir Thind,&nbsp;Holly A Shill,&nbsp;Lucia I Sue,&nbsp;John N Caviness,&nbsp;Sandra Jacobson,&nbsp;Marwan N Sabbagh","doi":"10.12988/cems.2013.13026","DOIUrl":"https://doi.org/10.12988/cems.2013.13026","url":null,"abstract":"<p><strong>Background: </strong>Hippocampal sclerosis (HS) is a neuropathological finding that frequently occurs with pathologies, such as Alzheimer's disease (AD). Prevalence estimates of HS in autopsy-confirmed dementia samples have varied between 0.4% and 24.5%. However, the prevalence of HS within other pathologic groups has not been well characterized.</p><p><strong>Methods: </strong>Utilizing a sample of 910 prospectively followed and clinicopathologically confirmed dementia cases, we determined the prevalence of HS among the sample and within specific pathologic groups. HS prevalence of the sample was compared to reported HS prevalence rates in other autopsy-confirmed dementia samples.</p><p><strong>Results: </strong>The age range of the sample was 43 to 106 years, with a mean of 81.49±8.45. Of the 910 cases, 505 were male and 405 were female. For the entire sample, the average educational level was 14.59±2.65years. Of the 910 individuals, 47 (5.16%) cases had HS pathology present at autopsy. Among the 561 AD cases, 26 (4.43%) had HS pathology present. The frontotemporal dementia (FTD)/Pick's group had the highest percentage of cases with HS pathology (23.08%) followed by primary progressive aphasia (PPA) (16.67%) and Parkinson's disease with dementia (PDD) (5.34%). The HS prevalence rate of this study was not significantly different from all but 2 studies.</p><p><strong>Conclusion: </strong>The prevalence of HS pathology in this sample of autopsy-confirmed dementia cases was similar to other reported HS prevalence rates. This study is the first to report the presence of HS pathology in PDD cases.</p>","PeriodicalId":90468,"journal":{"name":"Clinical and Experimental Medical Sciences","volume":"1 7","pages":"317-327"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4196704/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32755190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
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