Journal of preventive cardiology最新文献

{"title":"Trials of Maharishi Ayurveda for cardiovascular disease: A pooled analysis of outcome studies with carotid intima-media thickness.","authors":"Kenneth G Walton,&nbsp;Brian Olshansky,&nbsp;Erika Helene,&nbsp;Robert H Schneider","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>To investigate a multimodality, natural medicine systems approach-Maharishi Ayurveda (MAV)-for prevention or reversal of atherosclerotic cardiovascular disease (ASCVD).</p><p><strong>Design: </strong>Pooled analysis of data from existing trials that used MAV to reduce carotid artery intima-media thickness (CIMT).</p><p><strong>Settings: </strong>Two large medical centers in the U.S. Midwest.</p><p><strong>Subjects: </strong>Thirty-four elderly patients with or at high risk for ASCVD.</p><p><strong>Interventions: </strong>Four components of MAV: Transcendental Meditation^™, Ayurvedic diet, Ayurvedic exercise, and Ayurvedic herbal food supplements.</p><p><strong>Primary outcome measure: </strong>CIMT, a surrogate measure of ASCVD, was determined by B-mode ultrasonography.</p><p><strong>Results: </strong>After 9-12 months of intervention, CIMT declined in the MAV group (change in CIMT = -0.15 ± 0.22 mm; 95% CI = -0.22 to 0.01 mm) and increased in the usual care group (change in CIMT = + 0.02 ± 0.06 mm; 95% CI = -0.02 to 0.04). This difference between groups of -0.17 mm was significant [<i>F</i>(1,29) = 14.1, <i>p</i> << .01]. In the MAV group, those individuals showing the largest reductions in CIMT with treatment also had the highest risk factor levels at the start. Baseline data from this subgroup indicated the presence of hypertension, (systolic blood pressure (SBP) = 141 ± 11 mmHg, diastolic blood pressure (DBP) = 80 ± 12 mmHg, means ± SD). They also had elevated waist circumference (91 ± 8 cm), and dyslipidemia (triglyceride-to-HDL-cholesterol ratio = 4.8 ± 2.9). Each individual in this \"high-CIMT-change\" group, 80% of whom were women, improved notably in one or more risk factors with the MAV intervention.</p><p><strong>Conclusions: </strong>The pooled results of these two trials suggest that MAV multimodality intervention programs, including the Transcendental Meditation technique and heart-healthy Ayurvedic diet, exercise, and herbal food supplements, may be effective in the regression of ASCVD, especially in patients at high risk for cardiovascular disease.</p>","PeriodicalId":90233,"journal":{"name":"Journal of preventive cardiology","volume":"4 1","pages":"615-623"},"PeriodicalIF":0.0,"publicationDate":"2014-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9223439/pdf/nihms-1816482.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40397964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of omega-6 fatty acids on cardiovascular outcomes: A review.","authors":"Shweta Khandelwal, Laura Kelly, Richa Malik, Dorairaj Prabhakaran, Srinath Reddy","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Poly unsaturated fatty acids (PUFAs) have usually been associated with beneficial health effects on early life and later life disease such as cardiovascular diseases (CVD). Emerging evidence, however, suggests that PUFA species (n-3, n-6) have differential health effects. N-6 PUFAs, in particular, have sparked a scientific debate regarding their role in human physiological processes. Current dietary recommendations for n-6 fatty acids have been based on animal studies, insufficient epidemiological evidence and mixed PUFA interventions, therefore, require reconsideration. This review has analyzed human epidemiological and interventional studies, published in the last five years, focusing on n-6 fatty acids' impact on CVD outcomes (CVD events, blood lipids, blood pressure, inflammation, oxidative stress/atherosclerosis). The evidence is mixed, with differential effects within the n-6 fatty acid series. These outcomes are also dependent on ethnicity and background health status. Further, data from developing countries are sparse, thus, well designed intervention trials and population based studies in developing country settings on specific n-6 fatty acid intake and health effects are desired.</p>","PeriodicalId":90233,"journal":{"name":"Journal of preventive cardiology","volume":"2 3","pages":"325-336"},"PeriodicalIF":0.0,"publicationDate":"2013-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4062196/pdf/nihms567595.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32446670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}