International journal of clinical anesthesiology最新文献

筛选
英文 中文
Clinical Implications of Bilirubin-Associated Neuroprotection and Neurotoxicity. 胆红素相关神经保护和神经毒性的临床意义。
International journal of clinical anesthesiology Pub Date : 2013-09-01 Epub Date: 2013-09-29
Nicholas V Mendez, Jeffrey A Wharton, Jenna L Leclerc, Spiros L Blackburn, Martha V Douglas-Escobar, Michael D Weiss, Christoph N Seubert, Sylvain Doré
{"title":"Clinical Implications of Bilirubin-Associated Neuroprotection and Neurotoxicity.","authors":"Nicholas V Mendez,&nbsp;Jeffrey A Wharton,&nbsp;Jenna L Leclerc,&nbsp;Spiros L Blackburn,&nbsp;Martha V Douglas-Escobar,&nbsp;Michael D Weiss,&nbsp;Christoph N Seubert,&nbsp;Sylvain Doré","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Bilirubin is a primary product of heme catabolism and exhibits both neuroprotective and neurotoxic effects. When present at physiologic concentrations, bilirubin is a potent antioxidant and serves to protect brain tissue from oxidative stress insults. The use of the anesthetic propofol attenuates ischemic injury in rats by exploiting these neuroprotective properties. At pathologic levels, bilirubin has been implicated as a neurotoxic agent, demonstrating the ability to aggregate and adhere to cellular membranes, thereby disrupting normal cellular function. Bilirubin-associated toxicities are amplified by administering drugs such as anesthetics that compete with bilirubin for albumin binding sites, resulting in increased plasma bilirubin concentrations. As such, it is crucial that bilirubin is considered in the critical care management of patients with hemorrhagic stroke, cerebral ischemic damage, and critically ill newborns.</p>","PeriodicalId":90182,"journal":{"name":"International journal of clinical anesthesiology","volume":"1 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2013-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5998657/pdf/nihms805117.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36230139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Emerging model in anesthetic developmental neurotoxicity: human stem cells. 麻醉发育神经毒性的新模型:人类干细胞。
Xiaowen Bai, Zeljko J Bosnjak
{"title":"Emerging model in anesthetic developmental neurotoxicity: human stem cells.","authors":"Xiaowen Bai,&nbsp;Zeljko J Bosnjak","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":90182,"journal":{"name":"International journal of clinical anesthesiology","volume":"1 ","pages":"1002"},"PeriodicalIF":0.0,"publicationDate":"2013-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4068347/pdf/nihms519079.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32459500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信