General medicine (Los Angeles, Calif.)最新文献

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Effects of Physician Communication and Family Hardiness on Patient Medication Regimen Beliefs and Adherence. 医师沟通与家庭态度对患者用药方案信念与依从性的影响。

General medicine (Los Angeles, Calif.) Pub Date : 2014-01-01 DOI: 10.4172/2327-5146.1000136

Todd D Molfenter, Roger L Brown

{"title":"Effects of Physician Communication and Family Hardiness on Patient Medication Regimen Beliefs and Adherence.","authors":"Todd D Molfenter, Roger L Brown","doi":"10.4172/2327-5146.1000136","DOIUrl":"https://doi.org/10.4172/2327-5146.1000136","url":null,"abstract":"This study aims to develop a model that describes how physician communication and family hardiness affect medication regimen beliefs and adherence for patients on regimens to control diabetes and hyperlipidemia (high cholesterol). Study participants (n=1356) completed self-report questionnaires on health beliefs. Pharmacy refill records from a health plan in the United States provided data on their medication adherence. Structural equation modeling was used to model variable relationships. A mediation analysis demonstrated that physician communication behaviors had a significant impact on the patients' behavioral intention to adhere to their regimen and medication adherence when they were mediated by the patient's medication taking health beliefs related to perceived benefit of the regimen, impact of side effects, and cost of regimen. Conversely, family hardiness had no effect on medication-taking behaviors. To improve patient medication-taking behaviors, physician communication behaviors should be targeted. The study suggests the physician's initial regimen discussion is important to both regimen initiation and long-term adherence, and should emphasize the regimen's benefits and how to avoid common side effects. Also, establishing a follow-up physician-patient relationship can enhance regimen adherence and reduce the likelihood that a patient will stop taking the medication due to cost concerns. The research supports the important role the physician plays in health behavior maintenance. Future research should study the effect physicians have on other recurring health behaviors.","PeriodicalId":90169,"journal":{"name":"General medicine (Los Angeles, Calif.)","volume":"2 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2327-5146.1000136","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32979525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Congenital and Acute Kidney Disease: Translational Research Insights from Zebrafish Chemical Genetics. 先天性和急性肾病:斑马鱼化学遗传学的转化研究见解。

General medicine (Los Angeles, Calif.) Pub Date : 2013-09-01 DOI: 10.4172/2327-5146.1000112

Shahram Jevin Poureetezadi, Rebecca A Wingert

{"title":"Congenital and Acute Kidney Disease: Translational Research Insights from Zebrafish Chemical Genetics.","authors":"Shahram Jevin Poureetezadi, Rebecca A Wingert","doi":"10.4172/2327-5146.1000112","DOIUrl":"https://doi.org/10.4172/2327-5146.1000112","url":null,"abstract":"Today, acute kidney injury (AKI) and congenital anomalies of the kidney and urinary tract (CAKUT) represent major issues in healthcare. Both AKI and CAKUT can lead to end stage renal disease (ESRD) that requires life-long medical care with renal replacement therapy. Renal replacement by dialysis is intensive, and kidney transplantation is restricted by organ availability. These limitations, along with the growing epidemic of patients affected by kidney disease, highlight the significant need to identify alternative ways to treat renal injury and birth defects. Drug discovery is one promising avenue of current research. Here, we discuss zebrafish chemical genetics and its latent potency as a method to rapidly identify small molecule therapeutics to accelerate recovery after AKI. Specifically, we review two groundbreaking studies that have recently provided a template to screen for compounds that expand the renal progenitor field in development that were capable of treating AKI in both the zebrafish and the mouse. These new findings demonstrate that drug discovery using zebrafish can be used for relevant translational research to identify clinical interventions for renal conditions in humans.","PeriodicalId":90169,"journal":{"name":"General medicine (Los Angeles, Calif.)","volume":"1 3","pages":"112"},"PeriodicalIF":0.0,"publicationDate":"2013-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2327-5146.1000112","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32197044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 21