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Tularemia vaccine development: paralysis or progress? 兔热病疫苗的发展:瘫痪还是进步?
Vaccine (Auckland, N.Z.) Pub Date : 2016-01-01 Epub Date: 2016-05-04 DOI: 10.2147/VDT.S85545
Raju Sunagar, Sudeep Kumar, Brian J Franz, Edmund J Gosselin
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引用次数: 25
The utility of human challenge studies in vaccine development: lessons learned from cholera. 人体挑战研究在疫苗开发中的应用:从霍乱中吸取的教训。
Vaccine (Auckland, N.Z.) Pub Date : 2011-10-01 DOI: 10.2147/VDT.S23634
Debbie-Ann T Shirley, Monica A McArthur
{"title":"The utility of human challenge studies in vaccine development: lessons learned from cholera.","authors":"Debbie-Ann T Shirley,&nbsp;Monica A McArthur","doi":"10.2147/VDT.S23634","DOIUrl":"https://doi.org/10.2147/VDT.S23634","url":null,"abstract":"<p><p>Experiments in which virulent infectious organisms are administered to healthy adult volunteers with the intent to deliberately induce infection have been practiced for centuries. Many useful applications have developed from these experiments such as the provision of evidence of microbial pathogenicity and the identification of key virulence factors. Challenge studies have also played an important role in the evaluation of preliminary efficacy of potential vaccine candidates. Over the past 40 years, these experimental human challenge studies have found particular utility with regards to the development of both living and nonliving attenuated cholera vaccines. This review highlights some of the important contributions made by these challenge studies to cholera vaccine research.</p>","PeriodicalId":90078,"journal":{"name":"Vaccine (Auckland, N.Z.)","volume":"2011 1","pages":"3-13"},"PeriodicalIF":0.0,"publicationDate":"2011-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2147/VDT.S23634","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32079649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 42
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