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Antifungal cyclic peptides from the marine sponge Microscleroderma herdmani. 海绵体小硬皮病抗真菌环状肽。
Research and reports in medicinal chemistry Pub Date : 2013-03-13 DOI: 10.2147/RRMC.S44029
Xiaohui Zhang, M. Jacob, R. Rao, Yan-Hong Wang, A. Agarwal, D. Newman, I. Khan, A. Clark, Xing-Cong Li
{"title":"Antifungal cyclic peptides from the marine sponge Microscleroderma herdmani.","authors":"Xiaohui Zhang, M. Jacob, R. Rao, Yan-Hong Wang, A. Agarwal, D. Newman, I. Khan, A. Clark, Xing-Cong Li","doi":"10.2147/RRMC.S44029","DOIUrl":"https://doi.org/10.2147/RRMC.S44029","url":null,"abstract":"Screening natural product extracts from the National Cancer Institute Open Repository for antifungal discovery afforded hits for bioassay-guided fractionation. Using LC-MS analysis to generate chemical structure information on potentially active compounds, two new cyclic hexapeptides, microsclerodermins J (1) and K (2), were isolated from the deep-water sponge Microscleroderma herdmani, along with microsclerodermins A (3) and B (4), previously isolated from an unidentified Microscleroderma species. The structures of the new compounds were elucidated by spectroscopic analysis and chemical methods. In vitro antifungal testing showed that the four compounds possessed strong activities against the opportunistic fungal pathogens Candida albicans, Candida glabrata, Candida krusei, Cryptococcus neoformans, and Aspergillus fumigatus.","PeriodicalId":90044,"journal":{"name":"Research and reports in medicinal chemistry","volume":"2 1","pages":"7-14"},"PeriodicalIF":0.0,"publicationDate":"2013-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2147/RRMC.S44029","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68478168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 14
Antifungal cyclic peptides from the marine sponge Microscleroderma herdmani. 海绵体小硬皮病抗真菌环状肽。
Research and reports in medicinal chemistry Pub Date : 2012-05-22 DOI: 10.2147/RRMC.S30895
Xiaohui Zhang, Melissa R Jacob, R Ranga Rao, Yan-Hong Wang, Ameeta K Agarwal, David J Newman, Ikhlas A Khan, Alice M Clark, Xing-Cong Li
{"title":"Antifungal cyclic peptides from the marine sponge <i>Microscleroderma herdmani.</i>","authors":"Xiaohui Zhang,&nbsp;Melissa R Jacob,&nbsp;R Ranga Rao,&nbsp;Yan-Hong Wang,&nbsp;Ameeta K Agarwal,&nbsp;David J Newman,&nbsp;Ikhlas A Khan,&nbsp;Alice M Clark,&nbsp;Xing-Cong Li","doi":"10.2147/RRMC.S30895","DOIUrl":"https://doi.org/10.2147/RRMC.S30895","url":null,"abstract":"<p><p>Screening natural product extracts from the National Cancer Institute Open Repository for antifungal discovery afforded hits for bioassay-guided fractionation. Using LC-MS analysis to generate chemical structure information on potentially active compounds, two new cyclic hexapeptides, microsclerodermins J (<b>1</b>) and K (<b>2</b>), were isolated from the deep-water sponge <i>Microscleroderma herdmani</i>, along with microsclerodermins A (<b>3</b>) and B (<b>4</b>), previously isolated from an unidentified <i>Microscleroderma</i> species. The structures of the new compounds were elucidated by spectroscopic analysis and chemical methods. In vitro antifungal testing showed that the four compounds possessed strong activities against the opportunistic fungal pathogens <i>Candida albicans</i>, C<i>andida glabrata, Candida krusei, Cryptococcus neoformans</i>, and <i>Aspergillus fumigatus</i>.</p>","PeriodicalId":90044,"journal":{"name":"Research and reports in medicinal chemistry","volume":"2 ","pages":"7-14"},"PeriodicalIF":0.0,"publicationDate":"2012-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2147/RRMC.S30895","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31649835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
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