Journal of cardiovascular disease最新文献

Gene Deletion of VIP Leads to Increased Mortality Associated with Progressive Right Ventricular Hypertrophy. VIP基因缺失导致进行性右心室肥厚患者死亡率增加。

Journal of cardiovascular disease Pub Date : 2014-04-01

Anthony M Szema, Sayyed A Hamidi

引用次数: 0

The Impact of Myocardial Infarction vs. Pneumonia on Outcome in Acute Ischemic Stroke. 心肌梗死与肺炎对急性缺血性脑卒中预后的影响。

Journal of cardiovascular disease Pub Date : 2014-01-01

Tiffany L Mathias, Karen C Albright, Amelia K Boehme, Dominique Monlezun, Alexander J George, Erica Jones, T Mark Beasley, Sheryl Martin-Schild

{"title":"The Impact of Myocardial Infarction vs. Pneumonia on Outcome in Acute Ischemic Stroke.","authors":"Tiffany L Mathias, Karen C Albright, Amelia K Boehme, Dominique Monlezun, Alexander J George, Erica Jones, T Mark Beasley, Sheryl Martin-Schild","doi":"","DOIUrl":"","url":null,"abstract":"The aim of this study was to examine the association between MI and PNA in the setting of acute ischemic stroke and patient outcome. Eligible patients were identified from a prospectively collected stroke registry and included if transthoracic echocardiography (TTE) was performed during their inpatient stay. 426 patients met inclusion criteria (mean age 64, 73% Black, 48% female). Twenty-one patients (4.9%) experienced an MI. Patients who later suffered a MI initially presented with more severe strokes (median NIHSS 7 vs. 5, p=0.014). More patients in the MI group experienced pneumonia (26% vs. 9%, p=0.004). After adjusting for age, baseline glucose and NIHSS, the odds of in-hospital mortality for patients with MI was 3 times that of those without MI (OR 3.2 95% CI 1.1-9.7, p=0.036). When adjustment was made for pneumonia, age, baseline glucose and NIHSS, MI was no longer significantly related to in-hospital mortality (OR 2.5 95% CI 0.8-8.2, p=0.131). In our sample, while MI was significantly associated with in-hospital mortality, this association was attenuated after adjusting for presence of pneumonia. Our findings raise the question as to whether the prevention of pneumonia could improve in-hospital mortality among patients who experience MI in the setting of ischemic stroke.","PeriodicalId":89966,"journal":{"name":"Journal of cardiovascular disease","volume":"2 1","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3882195/pdf/nihms-539852.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32013387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Femoral Artery Occlusion Increases Muscle Pressor Reflex and Expression of Hypoxia-Inducible Factor-1α in Sensory Neurons. 股动脉闭塞增加肌肉加压反射和缺氧诱导因子-1α在感觉神经元中的表达。

Journal of cardiovascular disease Pub Date : 2013-10-01

Wei Gao, Jianhua Li

{"title":"Femoral Artery Occlusion Increases Muscle Pressor Reflex and Expression of Hypoxia-Inducible Factor-1α in Sensory Neurons.","authors":"Wei Gao, Jianhua Li","doi":"","DOIUrl":"","url":null,"abstract":"Hypoxia inducible factor-1 (HIF-1) has an important contribution to pathophysiological changes of homeostasis under conditions of oxygen deprivation as well as ischemia. We examined the effects of femoral artery occlusion on HIF-1α expression in sensory dorsal root ganglion (DRG) neurons of rats. Also, we examined cardiovascular responses to static muscle contraction following femoral occlusion. We hypothesized that hindlimb vascular insufficiency increases the levels of sensory nerves' HIF-1α and augments autonomic responses induced by activation of muscle afferent nerves. In addition, we examined if the reflex cardiovascular responses were altered as HIF-1α was increased in the DRG neurons. Our data show that HIF-1α was significantly increased in the lumbar DRG neurons 6, 24 and 72 hours after femoral artery ligation as compared with sham control. Administration of dimethyloxalylglycine (DMOG), a stabilizer of HIF-α, significantly increased HIF-1α in the lumbar DRG neurons. Furthermore, femoral occlusion enhanced the reflex pressor response to muscle contraction; however, the response was not altered by injection of DMOG. Overall, our results indicate that 1) femoral artery occlusion increases HIF-1α levels of in DRG neurons and contraction-induced pressor response; and 2) an increase in HIF-1α of DRG neurons per se may not alter the muscle pressor reflex.","PeriodicalId":89966,"journal":{"name":"Journal of cardiovascular disease","volume":"1 2","pages":"34-40"},"PeriodicalIF":0.0,"publicationDate":"2013-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207090/pdf/nihms-528477.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32772535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cardiac Function and Short-Term Outcome in Patients with Acute Ischemic Stroke: A Cross-Sectional Study. 急性缺血性脑卒中患者的心功能和短期预后：一项横断面研究。

Journal of cardiovascular disease Pub Date : 2013-10-01

Tiffany L Mathias, Karen C Albright, Amelia K Boehme, Alexander J George, Dominique Monlezun, Erica Jones, T Mark Beasley, Sheryl Martin-Schild

{"title":"Cardiac Function and Short-Term Outcome in Patients with Acute Ischemic Stroke: A Cross-Sectional Study.","authors":"Tiffany L Mathias, Karen C Albright, Amelia K Boehme, Alexander J George, Dominique Monlezun, Erica Jones, T Mark Beasley, Sheryl Martin-Schild","doi":"","DOIUrl":"","url":null,"abstract":"Few studies have investigated the relationship between left ventricular ejection fraction (LVEF) and functional outcome in ischemic stroke patients. The purpose of this study was to determine if a low LVEF in ischemic stroke was associated with functional outcome. A cross-sectional study was performed on ischemic stroke patients admitted to a single academic stroke center from June 2008 to December 2010. LVEF was determined using transthoracic or transesophageal echocardiography. Patients were categorized into three LVEF groups: severely low (<30%), moderately low (30-49%), and normal (>50%). Baseline demographics, in-hospital complications, and early outcomes were compared among LVEF groups using Chi-square, Wilcoxon rank sum, and logistic regression.590 patients met inclusion criteria (median age 65, 74% African American, 48% female). LVEF was normal in 79.8%, moderately low in 10.8%, and severely low in 9.3%. A smaller proportion of patients with severely low LVEF appeared to have good functional outcome compared to other groups (26% vs. 40% vs. 45%, p=0.028); however, this relationship was not significant after adjusting for age, baseline National Institute of Health Stroke Scale score and admission glucose (OR 0.6, 95% CI 0.3-1.3, p=0.216). Low LVEF was not an independent, significant predictor of short-term functional outcomes in ischemic stroke patients.","PeriodicalId":89966,"journal":{"name":"Journal of cardiovascular disease","volume":"1 2","pages":"26-29"},"PeriodicalIF":0.0,"publicationDate":"2013-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3931767/pdf/nihms-528586.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32148527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0