American journal of Alzheimer's disease (Columbia, Mo.)最新文献

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The role of Thyrotropin Releasing Hormone in aging and neurodegenerative diseases. 促甲状腺激素释放激素在衰老和神经退行性疾病中的作用。

American journal of Alzheimer's disease (Columbia, Mo.) Pub Date : 2013-01-01 DOI: 10.7726/ajad.2013.1003

Caitlin M Daimon, Patrick Chirdon, Stuart Maudsley, Bronwen Martin

引用次数: 0

Variation in Variables that Predict Progression from MCI to AD Dementia over Duration of Follow-up. 在随访期间预测MCI到AD痴呆进展的变量的变化。

American journal of Alzheimer's disease (Columbia, Mo.) Pub Date : 2013-01-01 DOI: 10.7726/ajad.2013.1002

Shanshan Li, Ozioma Okonkwo, Marilyn Albert, Mei-Cheng Wang

{"title":"Variation in Variables that Predict Progression from MCI to AD Dementia over Duration of Follow-up.","authors":"Shanshan Li, Ozioma Okonkwo, Marilyn Albert, Mei-Cheng Wang","doi":"10.7726/ajad.2013.1002","DOIUrl":"https://doi.org/10.7726/ajad.2013.1002","url":null,"abstract":"The purpose of this paper is to investigate the relative utility of using neuroimaging, genetic, cerebrospinal fluid (CSF), and cognitive measures to predict progression from mild cognitive impairment (MCI) to Alzheimer's disease (AD) dementia over a follow-up period. The studied subjects were 139 persons with MCI enrolled in the Alzheimer's Disease Neuroimaging Initiative. Predictors of progression to AD included brain volume, ventricular volume, hippocampal volume, APOE ε4 two alleles, Aβ42, p-tau181, p-tau181/Aβ42, memory, language, and executive function. We employ a combination of Cox regression analyses and time-dependent receiver operating characteristic (ROC) methods to assess the prognostic utility and performance stability of candidate biomarkers. In a demographic-adjusted multivariable Cox model, seven measures- brain volume, hippocampal volume, ventricular volume, APOE ε4 two alleles, Aβ42, Memory composite, Executive function composite - predicted progression to AD. Time-dependent ROC revealed that this multivariable model had an area under the curve of 0.832, 0.788, 0.794, and 0.757 at 12, 18, 24, and 36 months respectively. Supplemental Cox models with time of origin set differentially at 12, 18, 24 and 36 months showed that six measures were significant predictors at 12 months whereas only memory and executive function predicted progression to AD at 18 and 24 months. The authors concluded that baseline volumetric MRI and cognitive measures selectively predict progression from MCI to AD, with cognitive measures remaining predictive even late in the follow-up period. These findings may inform case selection for AD clinical trials.","PeriodicalId":89883,"journal":{"name":"American journal of Alzheimer's disease (Columbia, Mo.)","volume":"2 1","pages":"12-28"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.7726/ajad.2013.1002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32115582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 35

Cortical thickness and semantic fluency in Alzheimer's disease and mild cognitive impairment. 阿尔茨海默病和轻度认知障碍的皮质厚度和语义流畅性。

American journal of Alzheimer's disease (Columbia, Mo.) Pub Date : 2013-01-01 DOI: 10.7726/ajad.2013.1006

Jennifer A Eastman, Kristy S Hwang, Andreas Lazaris, Nicole Chow, Leslie Ramirez, Sona Babakchanian, Ellen Woo, Paul M Thompson, Liana G Apostolova

{"title":"Cortical thickness and semantic fluency in Alzheimer's disease and mild cognitive impairment.","authors":"Jennifer A Eastman, Kristy S Hwang, Andreas Lazaris, Nicole Chow, Leslie Ramirez, Sona Babakchanian, Ellen Woo, Paul M Thompson, Liana G Apostolova","doi":"10.7726/ajad.2013.1006","DOIUrl":"https://doi.org/10.7726/ajad.2013.1006","url":null,"abstract":"The hallmark of Alzheimer's disease (AD) is declarative memory loss, but deficits in semantic fluency are also observed. We assessed how semantic fluency relates to cortical atrophy to identify specific regions that play a role in the loss of access to semantic information. Whole-brain structural magnetic resonance imaging (MRI) data were analyzed from 9 Normal Control (NC)(M=76.7, SD=5.6), 40 Mild Cognitive Impairment (MCI) (M=74.4, SD=8.6), and 10 probable AD (M=72.4, SD=8.0) subjects from the Alzheimer's Disease Neuroimaging Initiative (ADNI). They all were administered the Category Fluency (CF) animals and vegetables tests. Poorer semantic fluency was associated with bilateral cortical atrophy of the inferior parietal lobule (Brodman areas (BA) 39 and 40) and BA 6, 8, and 9 in the frontal lobe, as well as BA 22 in the temporal lobe. More diffuse frontal associations were seen in the left hemisphere involving BA 9, 10, 32, 44, 45, and 46. Additional cortical atrophy was seen in the temporoparietal (BA 37) and the right parastriate (BA 19, 18) cortices. Associations were more diffuse for performance on vegetable fluency than animal fluency. The permutation-corrected map-wise significance for CF animals was pcorrected=0.01 for the left hemisphere, and pcorrected=0.06 for the right hemisphere. The permutation-corrected map-wise significance for CF vegetables was pcorrected=0.009 for the left hemisphere, and pcorrected=0.03 for the right hemisphere. These results demonstrate the profound effect of cortical atrophy on semantic fluency. Specifically, tapping into semantic knowledge involves the frontal lobe in addition to the language cortices of the temporoparietal region.","PeriodicalId":89883,"journal":{"name":"American journal of Alzheimer's disease (Columbia, Mo.)","volume":"1 2","pages":"81-92"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207059/pdf/nihms594440.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32772529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 21