Journal of orthomolecular medicine : official journal of the Academy of Orthomolecular Medicine最新文献

High Dose Intravenous Vitamin C Treatment for Zika Fever. 高剂量静脉注射维生素C治疗寨卡热。

Journal of orthomolecular medicine : official journal of the Academy of Orthomolecular Medicine Pub Date : 2016-01-01

Michael J Gonzalez, Miguel J Berdiel, Jorgé R Miranda-Massari, Jorgé Duconge, Joshua L Rodríguez-López, Pedro A Adrover-López

{"title":"High Dose Intravenous Vitamin C Treatment for Zika Fever.","authors":"Michael J Gonzalez, Miguel J Berdiel, Jorgé R Miranda-Massari, Jorgé Duconge, Joshua L Rodríguez-López, Pedro A Adrover-López","doi":"","DOIUrl":"","url":null,"abstract":"The Zika Fever is a viral disease caused by a single-stranded RNA virus from the Flavivirus genus, Flaviviridae family, from the Spondweni group. Its transmission occurs through mosquito vectors, principally Aedes Aegypti. The most common symptoms of Zika are fever, rash, joint pain, and conjunctivitis (red eyes). Other common symptoms include muscle pain and headache. As of now, no vaccine exists for the virus and no official treatment has been developed aside from standard procedures of the use of acetaminophen (paracetamol) and non-steroidal anti-inflammatory drugs. This is a case report of a 54 year-old Hispanic female who arrived at the clinic with symptomatology congruent with the Zika fever. The patient was treated with high doses of intravenous vitamin C over three days. The symptoms resolved after the infusions without any side effects at day four. Recovery from this viral infection takes normally around two weeks. Based on the positive outcome in this case, we propose that intravenous vitamin C should be studied further as a potential treatment for acute viral infections.","PeriodicalId":89813,"journal":{"name":"Journal of orthomolecular medicine : official journal of the Academy of Orthomolecular Medicine","volume":"31 1","pages":"19-22"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9518686/pdf/nihms-1831628.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40385656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High Dose Intraveneous Vitamin C and Chikungunya Fever: A Case Report. 高剂量静脉注射维生素C与基孔肯雅热:一例报告。

Journal of orthomolecular medicine : official journal of the Academy of Orthomolecular Medicine Pub Date : 2014-01-01

Michael J Gonzalez, Jorge R Miranda-Massari, Miguel J Berdiel, Jorge Duconge, Joshua L Rodríguez-López, Ron Hunninghake, Vicente J Cobas-Rosario

{"title":"High Dose Intraveneous Vitamin C and Chikungunya Fever: A Case Report.","authors":"Michael J Gonzalez, Jorge R Miranda-Massari, Miguel J Berdiel, Jorge Duconge, Joshua L Rodríguez-López, Ron Hunninghake, Vicente J Cobas-Rosario","doi":"","DOIUrl":"","url":null,"abstract":"The Chikungunya (CHIKV) fever is a viral disease produced by a single-stranded RNA Alphavirus from the Togaviridae genus. Its transmission occurs only through mosquito vectors, principally Aedes aegypti. It requires a human-mosquito-human transmission cycle. It is associated with severe arthritis/arthralgias, myalgias, high fever, headache, and maculopapular rash. Joint ache appears to be symmetrical. The virus has an incubation period of 2 to 7 days, where the high fever is typically presented. It is followed by arthralgias and myalgias, and rashes, which last for 3 to 5 days. However, the arthralgias can persist for months after the infection, which can contribute to severe arthritis. As of now, no vaccine exists for the virus and no official treatment has been developed aside from standard procedures of the use of acetaminophen (paracetamol), and non-steroidal anti-inflammatory drugs. This is a case report of a 54-year old Hispanic individual that reported left shoulder pain, left knee pain and fever. The symptoms started on a Saturday in September 2014 in middle of the night. The patient was treated with high doses of intravenous vitamin C over two days. The symptoms resolved after the infusions without any side effects. Based on the positive outcome in this case, we propose that intravenous vitamin C should be studied further as a potential treatment for acute viral infections.","PeriodicalId":89813,"journal":{"name":"Journal of orthomolecular medicine : official journal of the Academy of Orthomolecular Medicine","volume":"29 4","pages":"154-156"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4335641/pdf/nihms662011.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33074030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Schedule Dependence in Cancer Therapy: Intravenous Vitamin C and the Systemic Saturation Hypothesis. 癌症治疗中的时间表依赖性：静脉注射维生素 C 和全身饱和假说

Journal of orthomolecular medicine : official journal of the Academy of Orthomolecular Medicine Pub Date : 2012-01-01

Michael J Gonzalez, Jorge R Miranda Massari, Jorge Duconge, Neil H Riordan, Thomas Ichim

{"title":"Schedule Dependence in Cancer Therapy: Intravenous Vitamin C and the Systemic Saturation Hypothesis.","authors":"Michael J Gonzalez, Jorge R Miranda Massari, Jorge Duconge, Neil H Riordan, Thomas Ichim","doi":"","DOIUrl":"","url":null,"abstract":"Despite the significant number of in vitro and in vivo studies to assess vitamin C effects on cancer following the application of large doses and its extensive use by alternative medicine practitioners in the USA; the precise schedule for successful cancer therapy is still unknown. Based on interpretation of the available data, we postulate that the relationship between Vitamin C doses and plasma concentration x time, the capability of tissue stores upon distribution, and the saturable mechanism of urinary excretion are all important determinants to understand the physiology of high intravenous vitamin C dose administration and its effect on cancer. Practitioners should pay more attention to the cumulative vitamin C effect instead of the vitamin C concentrations to account for observed discrepancy in antitumor response. We suggest that multiple, intermittent, short-term intravenous infusions of vitamin C over a longer time period will correlate with greater antitumor effects than do single continuous IV doses of the same total exposure. This approach would be expected to minimize saturation of renal reabsorption, providing a continuous \"dynamic flow\" of vitamin C in the body for optimal systemic exposure and clinical outcomes. This prevents the \"systemic saturation\" phenomena, which may recycle vitamin C and render it less effective as an anticancer agent. Nonetheless, more pharmacokinetic and pharmacodynamic studies are needed to fully understand this schedule-dependence phenomenon.","PeriodicalId":89813,"journal":{"name":"Journal of orthomolecular medicine : official journal of the Academy of Orthomolecular Medicine","volume":"27 1","pages":"9-12"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4031610/pdf/nihms476007.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32366235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mitochondria, Energy and Cancer: The Relationship with Ascorbic Acid. 线粒体、能量和癌症：与抗坏血酸的关系

Journal of orthomolecular medicine : official journal of the Academy of Orthomolecular Medicine Pub Date : 2010-01-01

Michael J González, Glorivee Rosario-Pérez, Angélica M Guzmán, Jorge R Miranda-Massari, Jorge Duconge, Julio Lavergne, Nadia Fernandez, Norma Ortiz, Ana Quintero, Nina Mikirova, Neil H Riordan, Carlos M Ricart

{"title":"Mitochondria, Energy and Cancer: The Relationship with Ascorbic Acid.","authors":"Michael J González, Glorivee Rosario-Pérez, Angélica M Guzmán, Jorge R Miranda-Massari, Jorge Duconge, Julio Lavergne, Nadia Fernandez, Norma Ortiz, Ana Quintero, Nina Mikirova, Neil H Riordan, Carlos M Ricart","doi":"","DOIUrl":"","url":null,"abstract":"Ascorbic Acid (AA) has been used in the prevention and treatment of cancer with reported effectiveness. Mitochondria may be one of the principal targets of ascorbate's cellular activity and it may play an important role in the development and progression of cancer. Mitochondria, besides generating adenosine triphosphate (ATP), has a role in apoptosis regulation and in the production of regulatory oxidative species that may be relevant in gene expression. At higher concentrations AA may increase ATP production by increasing mitochondrial electron flux, also may induce apoptotic cell death in tumor cell lines, probably via its pro-oxidant action In contrast, at lower concentrations AA displays antioxidant properties that may prevent the activation of oxidant-induced apoptosis. These concentration dependent activities of ascorbate may explain in part the seemingly contradictory results that have been reported previously.","PeriodicalId":89813,"journal":{"name":"Journal of orthomolecular medicine : official journal of the Academy of Orthomolecular Medicine","volume":"25 1","pages":"29-38"},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3615720/pdf/nihms208076.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31340684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

THE ILIOTIBIAL BAND FRICTION SYNDROME 髂胫束摩擦综合征

Journal of orthomolecular medicine : official journal of the Academy of Orthomolecular Medicine Pub Date : 1996-01-01 DOI: 10.1016/b978-0-323-39253-2.50173-7

C. P. Ross, P. Saunders

引用次数: 0