Vinoj H Sewberath Misser, Arti Shankar, Ashna Hindori-Mohangoo, Jeffrey Wickliffe, Maureen Lichtveld, Dennis R A Mans
{"title":"Prevalence and safety of prescription medicine use during pregnancy in the Republic of Suriname in the year 2017: a pharmacoepidemiological analysis.","authors":"Vinoj H Sewberath Misser, Arti Shankar, Ashna Hindori-Mohangoo, Jeffrey Wickliffe, Maureen Lichtveld, Dennis R A Mans","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Using the claims database of the State Health Foundation from 2017, the prevalence and safety of prescription medicines given to pregnant women in Suriname (South America) have been determined.</p><p><strong>Methods: </strong>Prescription rates and proportions of the total number of prescriptions were calculated, overall and stratified for subgroups of age, region of residence, major Anatomical Therapeutic Chemical - and safety classification (Australian categorization system). Data were compared with the Σ<sup>2</sup>-test and the two samples test of proportions using normal theory method; p-values <0.01 were considered statistically significant differences.</p><p><strong>Results: </strong>Average prescription rates (number of prescriptions by number of patients) were 24.0, 29.7, and 32.5 in age groups 15-29, 30-44, and 45+ years, respectively (p<0.001), and 26.4, 23.0, and 14.0 in the urban-coastal, rural-coastal, and rural-interior region, respectively (p<0.001).</p><p><strong>Conclusions: </strong>The use of prescription medicines was common (rates up to 40.4), ranged from antibiotics to vitamins, and most were safe. However, 3.2% (some antibiotics and antiepileptics) belonged to safety category D, carrying a definite human fetal risk. However, the potential benefits of these drugs warranted their use in pregnant women. These findings are largely in line with literature data, although future studies must verify their generalizability to the total Surinamese population.</p>","PeriodicalId":89734,"journal":{"name":"Advances in pharmacoepidemiology & drug safety","volume":"10 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8516118/pdf/nihms-1745134.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39526335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"TSH - Clinical Aspects of its Use in Determining Thyroid Disease in the Elderly. How Does it Impact the Practice of Medicine in Aging?","authors":"Mackenzie Deary, Timothy Buckey, Offie P Soldin","doi":"10.4172/2167-1052.1000119","DOIUrl":"https://doi.org/10.4172/2167-1052.1000119","url":null,"abstract":"<p><p>The last four decades have seen enormous growth in the efficacy of serum thyroid stimulating hormone (thyrotropin, TSH) assay methodology, establishing TSH as the hallmark of thyroid testing. At the center of the considerations is the strong inverse correlation between serum thyrotropin and free thyroxine concentrations. While it is widely accepted that elevated serum TSH concentrations are consistent with thyroid dysfunction, a vast multitude of additional factors must be considered before an accurate clinical diagnosis can be made followed by an appropriate treatment. Epidemiological studies have demonstrated slightly elevated serum TSH concentrations among the elderly population. There is, however, a debate whether these elevated TSH levels reflect an increased prevalence of hypothyroidism among the elderly or a normal aspect of healthy aging. A comprehensive analysis of the many variables associated with this debate and TSH measurement as a diagnostic tool in aging should provide insight into the clinical efforts to diagnose and treat thyroid disease, particularly in the elderly population.</p>","PeriodicalId":89734,"journal":{"name":"Advances in pharmacoepidemiology & drug safety","volume":"1 119","pages":""},"PeriodicalIF":0.0,"publicationDate":"2012-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2167-1052.1000119","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31234337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}