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Botulism mortality in the USA, 1975-2009. 1975-2009年美国肉毒中毒死亡率。
The botulinum journal Pub Date : 2015-01-01 Epub Date: 2016-08-04 DOI: 10.1504/TBJ.2015.078132
Kelly A Jackson, Barbara E Mahon, John Copeland, Ryan P Fagan
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引用次数: 0
Novel Benzimidazole Inhibitors of Botulinum Neurotoxin/A Display Enzyme and Cell-Based Potency. 新型苯并咪唑类肉毒毒素/A显示酶抑制剂及其细胞效价。
The botulinum journal Pub Date : 2011-01-01 DOI: 10.1504/tbj.2011.041813
Steven C Cardinale, Michelle M Butler, Gordon Ruthel, Jonathan E Nuss, Laura M Wanner, Bing Li, Ramdas Pai, Norton P Peet, Sina Bavari, Terry L Bowlin
{"title":"Novel Benzimidazole Inhibitors of Botulinum Neurotoxin/A Display Enzyme and Cell-Based Potency.","authors":"Steven C Cardinale, Michelle M Butler, Gordon Ruthel, Jonathan E Nuss, Laura M Wanner, Bing Li, Ramdas Pai, Norton P Peet, Sina Bavari, Terry L Bowlin","doi":"10.1504/tbj.2011.041813","DOIUrl":"10.1504/tbj.2011.041813","url":null,"abstract":"<p><p>Botulinum Neurotoxins (BoNTs) are used therapeutically and in cosmetics, providing potential for bioterrorist activity, thus driving the search for small-molecule BoNT inhibitors. This report describes a 70,000-compound screen for inhibition of BoNT/A using a FRET assay to detect proteolysis of a peptide substrate. Hits were confirmed, followed by evaluation to determine compound specificity. Inhibitors fell into three main chemical classes, and on the basis of potency and specificity of inhibition, the activities of two chemotypes were examined further. Compounds exhibited specificity for BoNT/A LC inhibition with respect to other metalloproteases and displayed activity in a neuronal assay for botulinum intoxication.</p>","PeriodicalId":89726,"journal":{"name":"The botulinum journal","volume":"2 1","pages":"16-29"},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3509773/pdf/nihms343946.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31093090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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