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Relations between cognitive status and medication adherence in patients treated for memory disorders. 记忆障碍患者认知状态与药物依从性的关系。

Ageing research Pub Date : 2012-09-01 DOI: 10.4081/ar.2012.e2

Raymond L Ownby, Christopher Hertzog, Sara J Czaja

{"title":"Relations between cognitive status and medication adherence in patients treated for memory disorders.","authors":"Raymond L Ownby, Christopher Hertzog, Sara J Czaja","doi":"10.4081/ar.2012.e2","DOIUrl":"https://doi.org/10.4081/ar.2012.e2","url":null,"abstract":"Medication adherence has been increasingly recognized as an important factor in elderly persons' health. Various studies have shown that medication non-adherence is associated with poor health status in this population. As part of a study of the effects of two interventions to promote medication adherence in patients treated for memory problems, information on medication adherence and cognitive status was collected at 3-month intervals. Twenty-seven participants (16 men, 11 women, age 71-92 years) were assigned to control or treatment conditions and adherence was evaluated with an electronic monitoring device. Cognitive status was evaluated at 3-month intervals beginning in April of 2003 and continuing through September of 2006. We have previously reported on the effectiveness of these interventions to promote adherence. In this paper, we examine the relations of cognitive status and adherence over time using a partial least squares path model in order to evaluate the extent to which adherence to cholinesterase medications was related to cognitive status. Adherence predicted cognitive status at later time points while cognition did not, in general, predict adherence. Results thus suggest that interventions to ensure high levels of medication adherence may be important for maintaining cognitive function in affected elderly people.","PeriodicalId":89654,"journal":{"name":"Ageing research","volume":"3 1","pages":"e2"},"PeriodicalIF":0.0,"publicationDate":"2012-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4081/ar.2012.e2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32158599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Ageing research Pub Date : 2011-04-28 DOI: 10.4081/ar.2011.e4

Laura E Gibbons, Paul K Crane, Kala M Mehta, Otto Pedraza, Yuxiao Tang, Jennifer J Manly, Kaavya Narasimhalu, Jeanne Teresi, Richard N Jones, Dan Mungas

{"title":"Multiple, correlated covariates associated with differential item functioning (DIF): Accounting for language DIF when education levels differ across languages.","authors":"Laura E Gibbons, Paul K Crane, Kala M Mehta, Otto Pedraza, Yuxiao Tang, Jennifer J Manly, Kaavya Narasimhalu, Jeanne Teresi, Richard N Jones, Dan Mungas","doi":"10.4081/ar.2011.e4","DOIUrl":"https://doi.org/10.4081/ar.2011.e4","url":null,"abstract":"Differential item functioning (DIF) occurs when a test item has different statistical properties in subgroups, controlling for the underlying ability measured by the test. DIF assessment is necessary when evaluating measurement bias in tests used across different language groups. However, other factors such as educational attainment can differ across language groups, and DIF due to these other factors may also exist. How to conduct DIF analyses in the presence of multiple, correlated factors remains largely unexplored. This study assessed DIF related to Spanish versus English language in a 44-item object naming test. Data come from a community-based sample of 1,755 Spanish- and English-speaking older adults. We compared simultaneous accounting, a new strategy for handling differences in educational attainment across language groups, with existing methods. Compared to other methods, simultaneously accounting for language- and education-related DIF yielded salient differences in some object naming scores, particularly for Spanish speakers with at least 9 years of education. Accounting for factors that vary across language groups can be important when assessing language DIF. The use of simultaneous accounting will be relevant to other cross-cultural studies in cognition and in other fields, including health-related quality of life.","PeriodicalId":89654,"journal":{"name":"Ageing research","volume":"2 1","pages":"19-25"},"PeriodicalIF":0.0,"publicationDate":"2011-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4081/ar.2011.e4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30840616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9