{"title":"Improving treatment adherence in patients with rheumatologic disease.","authors":"Sofia de Achaval, Maria E Suarez-Almazor","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Further evaluation of reasons for treatment nonadherence in patients with rheumatologic disease is key in the development of successful interventions. Patient education efforts alone are not sufficient to improve adherence; complex interventions are most effective. Because most rheumatologic diseases require lifetime therapy, the consequences of nonadherence can be deleterious. Several direct and indirect methods have been proposed to measure adherence. Pharmacy claims data have been used frequently in studying rheumatologic disease; electronic monitoring provides an accurate measure. Adherence is mediated through constructs of the patient-physician relationship.</p>","PeriodicalId":89499,"journal":{"name":"The Journal of musculoskeletal medicine","volume":"27 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2010-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3782860/pdf/nihms284375.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31769203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Hepatitis C-related arthropathy: Diagnostic and treatment considerations.","authors":"Nyingi M Kemmer, Kenneth E Sherman","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Hepatitis C-related arthropathy is one of the most common extrahepatic manifestations of hepatitis C virus (HCV) infection. Although symptoms can be disabling, the prognosis typically is benign. Patients who have atypical chronic inflammatory arthritis with an unknown cause should be evaluated for HCV infection. Testing for antibodies against cyclic citrullinated peptide is useful for distinguishing HCV-related arthropathy from rheumatoid arthritis. Early recognition of HCV infection greatly influences the selection of drug therapy. Although no clinical guidelines are available, many liver disease specialists favor using a stepwise approach to treatment. Future research efforts that focus on the pathogenesis of HCV-related arthropathy and novel therapeutic approaches are needed. (J Musculoskel Med. 2010;27:351-354).</p>","PeriodicalId":89499,"journal":{"name":"The Journal of musculoskeletal medicine","volume":"27 9","pages":"351-354"},"PeriodicalIF":0.0,"publicationDate":"2010-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3103264/pdf/nihms265623.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29901024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Recognizing the musculoskeletal manifestations of vitamin D deficiency.","authors":"Andrea N Jones, Karen E Hansen","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A disruption in any part of the vitamin D physiological pathway can result in vitamin D deficiency, which may lead to bone pain, muscle weakness, falls, low bone mass, and fractures. Recognizing the signs and symptoms helps physicians make a proper diagnosis and prescribe appropriate treatment. Physicians should suspect osteomalacia in patients who have prolonged vitamin D deficiency, a low serum calcium level, or a low serum phosphorus level. Patients with cystic fibrosis are at increased risk for deficiencies in fat-soluble vitamins, including vitamin D. Secondary hyperparathyroidism can develop in patients with chronic kidney disease as a result of low 25-hydroxyvitamin D levels or impaired conversion to 1,25-dihydroxyvitamin D. Patients may experience abnormal vitamin D metabolism as a result of taking anticonvulsants and other medications.</p>","PeriodicalId":89499,"journal":{"name":"The Journal of musculoskeletal medicine","volume":"26 10","pages":"389-396"},"PeriodicalIF":0.0,"publicationDate":"2009-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3188408/pdf/nihms-266203.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30195155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}