Pathogenesis : the journal of mechanisms in disease processes最新文献

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Pathogenesis of splenic marginal zone lymphoma 脾边缘区淋巴瘤的发病机制
Pathogenesis : the journal of mechanisms in disease processes Pub Date : 2015-11-01 DOI: 10.1016/J.PATHOG.2015.07.001
M. Du
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引用次数: 2
HER2: An emerging biomarker in non-breast and non-gastric cancers HER2:非乳腺癌和非胃癌的新兴生物标志物
Pathogenesis : the journal of mechanisms in disease processes Pub Date : 2015-08-01 DOI: 10.1016/J.PATHOG.2015.05.002
Norhayati Omar, B. Yan, M. Salto‐Tellez
{"title":"HER2: An emerging biomarker in non-breast and non-gastric cancers","authors":"Norhayati Omar, B. Yan, M. Salto‐Tellez","doi":"10.1016/J.PATHOG.2015.05.002","DOIUrl":"https://doi.org/10.1016/J.PATHOG.2015.05.002","url":null,"abstract":"","PeriodicalId":88949,"journal":{"name":"Pathogenesis : the journal of mechanisms in disease processes","volume":"12 1","pages":"1-9"},"PeriodicalIF":0.0,"publicationDate":"2015-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74480587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 31
Ultrastructural Analysis of Chlamydia Pneumoniae in the Alzheimer's Brain. 阿尔茨海默病脑组织肺炎衣原体超微结构分析。
E James Arking, Denah M Appelt, J Todd Abrams, Sonya Kolbe, Alan P Hudson, Brian J Balin
{"title":"Ultrastructural Analysis of Chlamydia Pneumoniae in the Alzheimer's Brain.","authors":"E James Arking, Denah M Appelt, J Todd Abrams, Sonya Kolbe, Alan P Hudson, Brian J Balin","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>We recently reported identification of the bacterium Chlamydia pneumoniae in affected brain regions of patients with Alzheimer's disease (AD) (Balin et al., 1998). In this report, we extend those initial observations to demonstrate that, in addition to the frequently described, standard morphological forms of the organism, pleiomorphic forms are also present in the AD brain. All AD and control brain tissues examined were verified to be PCR-positive and negative, respectively, for the organism. DNA sequence determination of PCR products so derived from total DNA of infected AD brains, as well as from total DNA of cell lines infected with the organism following isolation from these same patient samples, confirmed the presence of organism in relevant samples. Various morphologic forms of C. pneumoniae were identified in PCR-positive tissues and these were characterized based on membrane structure, core density, size, and immunolabeling profiles. Structures identified include the typical pear-shaped elementary body, as well as larger, spherical and oblong reticulate bodies. Intact C. pneumoniae were found both intracellularly and extracellularly in the sampled autopsy brains. Intracellular organisms were located principally within microglia, astroglia, and presumptive pericytes. These results suggest that C. pneumoniae found in cells indigenous to the AD brain do not conform universally to the classical morphology observed in other infected cell types. This pleiomorphism may reflect an adaptive response and/or persistent state of infection for these organisms in Alzheimer's Disease.</p>","PeriodicalId":88949,"journal":{"name":"Pathogenesis : the journal of mechanisms in disease processes","volume":"1 3","pages":"201-211"},"PeriodicalIF":0.0,"publicationDate":"1999-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2910921/pdf/nihms157873.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29155454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An audit into use of minimum dataset reporting of skin cancers in the North of England Cancer Network 对北英格兰癌症网络使用最小数据集报告皮肤癌的审计
Pathogenesis : the journal of mechanisms in disease processes Pub Date : 1900-01-01 DOI: 10.1016/J.PATHOG.2015.05.003
P. Barrett, H. E. Barrett
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引用次数: 7
The impact of next generation sequencing technologies on haematological research – A review 新一代测序技术对血液学研究的影响综述
Pathogenesis : the journal of mechanisms in disease processes Pub Date : 1900-01-01 DOI: 10.1016/J.PATHOG.2015.05.004
Jessica S. Black, M. Salto‐Tellez, K. Mills, M. Catherwood
{"title":"The impact of next generation sequencing technologies on haematological research – A review","authors":"Jessica S. Black, M. Salto‐Tellez, K. Mills, M. Catherwood","doi":"10.1016/J.PATHOG.2015.05.004","DOIUrl":"https://doi.org/10.1016/J.PATHOG.2015.05.004","url":null,"abstract":"","PeriodicalId":88949,"journal":{"name":"Pathogenesis : the journal of mechanisms in disease processes","volume":"2 1","pages":"9-16"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80468099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 20
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