International journal of computational science最新文献

筛选
英文 中文
Finding Occurrences of Relevant Functional Elements in Genomic Signatures. 在基因组特征中发现相关功能元件的出现。
Edwin Jacox, Laura Elnitski
{"title":"Finding Occurrences of Relevant Functional Elements in Genomic Signatures.","authors":"Edwin Jacox,&nbsp;Laura Elnitski","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>For genomic applications, signature-finding algorithms identify over-represented signatures (words) in collections of DNA sequences. The results can be presented as a specific sequence of bases, a consensus sequence showing possible combination of bases, or a matrix of weighted possibilities at each position. These results are often compared to a biological set of binding sites (i.e., known functional elements), which are usually represented as weighted matrices. The comparison is made by scoring the signatures against each weight matrix to identify the best option for a positive hit. However, this approach can misclassify results when applied to short sequences, which are a frequent result of signature finders. We describe a novel method using a window around the original sequences (those which the signature is based upon) to improve the comparison and identify a more significant measure of similarity. In doing so, our method transforms a list of DNA signatures into a resource of characterized binding sites with known functional roles and identifies novel elements in need of further elucidation.</p>","PeriodicalId":88523,"journal":{"name":"International journal of computational science","volume":"2 5","pages":"599-606"},"PeriodicalIF":0.0,"publicationDate":"2008-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2800375/pdf/nihms70363.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28625952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信