SOJ neurology最新文献

Deciphering the molecular logic of ALS using model organisms: "A family affair." 用模式生物破译ALS的分子逻辑:“家庭事务”。

SOJ neurology Pub Date : 2017-01-01 Epub Date: 2017-07-19 DOI: 10.15226/2374-6858/4/1/00132

Jonathan R Brent, P Hande Ozdinler

引用次数: 1

Anodal tDCS of the lower limb M1 does not acutely affect clinical blood pressure and heart rate in healthy and post stroke individuals. 在健康和脑卒中后个体中，下肢M1的淋巴结性tDCS不会急性影响临床血压和心率。

SOJ neurology Pub Date : 2015-11-11 DOI: 10.15226/2374-6858/2/2/00118

Tai T. Nguyen, J. Ugwu, S. Madhavan

{"title":"Anodal tDCS of the lower limb M1 does not acutely affect clinical blood pressure and heart rate in healthy and post stroke individuals.","authors":"Tai T. Nguyen, J. Ugwu, S. Madhavan","doi":"10.15226/2374-6858/2/2/00118","DOIUrl":"https://doi.org/10.15226/2374-6858/2/2/00118","url":null,"abstract":"Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation technique increasingly investigated an adjunct modality to enhance the effects of motor therapy. Although the safety of tDCS in relation to cognition, sensation and perception has been well reviewed, there still exists limited information regarding its effects on blood pressure and heart rate. As tDCS is being largely used in conjunction with stroke rehabilitation, it is important that we understand the effects of tDCS on autonomic function in the stroke population. In this retrospective study, we examined the acute effects of tDCS of the lower limb motor cortex in healthy and post stroke individuals using clinical measurements of blood pressure and heart rate. Fifteen minutes of 1 mA anodal tDCS did not cause any clinically detectable changes in blood pressure or heart rate. This is the first study to report the cardiovascular autonomic effects of tDCS of the lower limb M1 in healthy and post stroke individuals. Further studies are needed to examine if these safety effects are preserved during repeated applications of tDCS.","PeriodicalId":87364,"journal":{"name":"SOJ neurology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67332196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Elevation of Cardiac Troponins in Prolonged Status Epilepticus: A Retrospective Chart Analysis. 延长癫痫持续状态时心肌肌钙蛋白升高:回顾性图表分析。

SOJ neurology Pub Date : 2014-03-17 DOI: 10.15226/2374-6858/1/1/00105

N. Soundarya, Dm Lawrence, Jb Samip, Av Stacy, J. Robert, R. Leroy, R. Alan

{"title":"Elevation of Cardiac Troponins in Prolonged Status Epilepticus: A Retrospective Chart Analysis.","authors":"N. Soundarya, Dm Lawrence, Jb Samip, Av Stacy, J. Robert, R. Leroy, R. Alan","doi":"10.15226/2374-6858/1/1/00105","DOIUrl":"https://doi.org/10.15226/2374-6858/1/1/00105","url":null,"abstract":"INTRODUCTION\u0000To determine the clinical significance of elevation of Troponin-I [cTn-I] during prolonged status epilepticus [pSE] SE is known to be accompanied by an increase in sympathetic outflow. Elevation of cTn-I has been linked to myocardial stress. We hypothesize that in patients with risk factors for coronary artery disease[CAD], pSE may lead to myocardial stress and an elevation of cTn-I.\u0000\u0000\u0000METHODS\u0000This is a retrospective study of patients over the age of 18 years who were presented to Virginia Commonwealth University with SE between 2005 and 2010. Data was evaluated using the 30-minute definition for SE and 30 day mortality. Risk factors for CAD and cTn-I levels within the first 24 hours of diagnosis of pSE were analyzed.\u0000\u0000\u0000KEY FINDINGS\u0000There were a total of 435 patients with a confirmed diagnosis of pSE, of which 266 had cTn-I concentrations reported. Statistical analysis showed a significant association between CAD risk factors and cTn-I elevation (χ2 =12.87, p-value <0.01), with Crude Odds Ratio of 4.7. In patients with a CAD risk factor, an elevation of cTn-I is associated with a significantly increased risk of mortality, with an Odds ratio of 8.0, (χ2 =40, [95% CI 4.1-15.9] p-value < 0.01). Mortality was higher in those with an elevation of cTn-I [54.65%] as opposed to those who did not have an elevation [15.08%], irrespective of CAD risk factors. OR=6.7, (χ2 =45, [95% CI=3.7-12.2] p-value < 0.01).\u0000\u0000\u0000CONCLUSIONS\u0000In patients with pSE values, elevated cTn-I values are seen four to five time more often in those with CAD risk factors, as opposed to those without the risks. An elevation of cTn-I in this subgroup of patients with CAD risk factors was associated with an eight to nine fold increase in their 30 day mortality as compared to patients with pSE, who did not have an elevation of cTn-I.","PeriodicalId":87364,"journal":{"name":"SOJ neurology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67332105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Elevation of Cardiac Troponins in Prolonged Status Epilepticus: A Retrospective Chart Analysis. 延长癫痫持续状态时心肌肌钙蛋白升高:回顾性图表分析。

SOJ neurology Pub Date : 2014-01-01

Ng Soundarya, Dm Lawrence, Jb Samip, Av Stacy, Jc Robert, Rt Leroy, Rt Alan

{"title":"Elevation of Cardiac Troponins in Prolonged Status Epilepticus: A Retrospective Chart Analysis.","authors":"Ng Soundarya, Dm Lawrence, Jb Samip, Av Stacy, Jc Robert, Rt Leroy, Rt Alan","doi":"","DOIUrl":"","url":null,"abstract":"Introduction: To determine the clinical significance of elevation of Troponin-I [cTn-I] during prolonged status epilepticus [pSE] SE is known to be accompanied by an increase in sympathetic outflow. Elevation of cTn-I has been linked to myocardial stress. We hypothesize that in patients with risk factors for coronary artery disease[CAD], pSE may lead to myocardial stress and an elevation of cTn-I.Methods: This is a retrospective study of patients over the age of 18 years who were presented to Virginia Commonwealth University with SE between 2005 and 2010. Data was evaluated using the 30-minute definition for SE and 30 day mortality. Risk factors for CAD and cTn-I levels within the first 24 hours of diagnosis of pSE were analyzed.Key findings: There were a total of 435 patients with a confirmed diagnosis of pSE, of which 266 had cTn-I concentrations reported. Statistical analysis showed a significant association between CAD risk factors and cTn-I elevation (χ2 =12.87, p-value <0.01), with Crude Odds Ratio of 4.7. In patients with a CAD risk factor, an elevation of cTn-I is associated with a significantly increased risk of mortality, with an Odds ratio of 8.0, (χ2 =40, [95% CI 4.1-15.9] p-value < 0.01). Mortality was higher in those with an elevation of cTn-I [54.65%] as opposed to those who did not have an elevation [15.08%], irrespective of CAD risk factors. OR=6.7, (χ2 =45, [95% CI=3.7-12.2] p-value < 0.01).Conclusions: In patients with pSE values, elevated cTn-I values are seen four to five time more often in those with CAD risk factors, as opposed to those without the risks. An elevation of cTn-I in this subgroup of patients with CAD risk factors was associated with an eight to nine fold increase in their 30 day mortality as compared to patients with pSE, who did not have an elevation of cTn-I.","PeriodicalId":87364,"journal":{"name":"SOJ neurology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4327831/pdf/nihms649400.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33385700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0