Era socialista最新文献

{"title":"Proteogenomics for precision medicine: overcoming challenges in specificity, reproducibility, and data integration","authors":"Kuliesius, Simonas Jurgis","doi":"10.7488/era/6360","DOIUrl":"https://doi.org/10.7488/era/6360","url":null,"abstract":"The integration of proteomics with genomics—termed proteogenomics—offers an unprecedented opportunity to deepen our understanding of human biology, disease mechanisms, and biomarker discovery. Proteogenomics leverages protein abundance data to inform genomic analyses, refining our ability to detect and interpret variations in protein levels that underlie health and disease. However, despite its promise, proteogenomics faces several methodological and technological challenges, particularly in the precision, scalability, and reproducibility of proteomic measurements. Multiplex proteomics platforms have evolved significantly over the last decade, providing extensive coverage of the human proteome. Traditional techniques such as mass spectrometry have been challenged by affinity-based proteomics, including SomaLogic's SomaScan and Olink’s proximity extension assay, which have vastly expanded the depth of protein quantification to thousands of proteins. A fundamental challenge in proteogenomics today is target specificity and standardization. While genetic studies rely on the stability of DNA, proteins are highly dynamic, influenced by post-translational modifications, protein-protein interactions, and environmental conditions. Nonetheless, proteogenomics holds transformative potential in clinical and translational research. Large proteomic datasets are already discovering new pathways for disease and health, in addition to demonstrating predictive power in disease onset modelling, outperforming traditional clinical biomarkers. The increasing integration of machine learning into proteogenomics workflows promises to enhance biomarker discovery and clinical translation. This thesis explores the application of state-of-the-art proteomics technologies in proteogenomics, emphasizing their strengths, limitations, and implications for biomarker discovery and disease association studies. The work presented herein aims to address key challenges in proteomic specificity, cross-platform reproducibility, and the integration of proteomic data with genomic insights in small cohorts to advance precision medicine.","PeriodicalId":84669,"journal":{"name":"Era socialista","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://era.ed.ac.uk/bitstream/1842/43829/1/KuliesiusJK_2025.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147907883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Marvellous real in the Middle East: a comparative study of magical realism in contemporary women’s fiction","authors":"Alshehri, Ameerah Saleh","doi":"10.7488/era/1997","DOIUrl":"https://doi.org/10.7488/era/1997","url":null,"abstract":"Magical realism has been studied extensively in relation to Latin America and subsequently in other parts of the world, yet the Middle East has not received adequate attention in academic scholarship. This PhD study examines a selection of contemporary female-authored narratives from the Middle East to establish an understanding of the practice of magical realism in this region. The selected texts for this study are: Raja Alem’s Fatma and My Thousand and One Nights; Shahrnush Parsipur’s Women Without Men and Touba and the Meaning of Night; Elif Shafak’s The Bastard of Istanbul and Gina B. Nahai’s Moonlight on the Avenue of Faith. This study firstly explores the concept of magical realism as a mode of writing and determines its relationship to the Middle Eastern context. It then evaluates the texts under scrutiny by examining how the narrative of magical realism is constructed and what the sources are of the magical component in these texts, specifically in relation to Middle Eastern mythology. It also investigates the ideological aspect behind the employment of magical realism and whether it serves any political goal. The analysis of the selected texts is approached from three standpoints, that is, from literary, mythological and ideological perspectives. I argue that magical realism serves various purposes and that it is applied from perspectives that can be regarded as marginal to their communities’ dominant values, to subvert mainstream ideology. I also demonstrate that the Middle East is a crucial place to investigate magical realism because of the numerous complex cultural values that interact with each other in this region, and which enrich the practice of magical realism.","PeriodicalId":84669,"journal":{"name":"Era socialista","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147891841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[The census returns: a picture of the revolutionary changes taking place in Romania].","authors":"I Salapa","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":84669,"journal":{"name":"Era socialista","volume":"57 13","pages":"10-25"},"PeriodicalIF":0.0,"publicationDate":"1977-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22003700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}