Applied Immunohistochemistry & Molecular Morphology最新文献

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Clinicopathologic Analysis of HPV-Related Primary Squamous Cell Carcinoma of the Thyroid. HPV相关甲状腺原发性鳞状细胞癌的临床病理分析

IF 1.6 4区医学

Applied Immunohistochemistry & Molecular Morphology Pub Date : 2024-09-12 DOI: 10.1097/pai.0000000000001222

Chen Zhou,Feng Li,Gang Chen,Chao Wu,Jin-Gui Jiang,Jing-Ling Duan

{"title":"Clinicopathologic Analysis of HPV-Related Primary Squamous Cell Carcinoma of the Thyroid.","authors":"Chen Zhou,Feng Li,Gang Chen,Chao Wu,Jin-Gui Jiang,Jing-Ling Duan","doi":"10.1097/pai.0000000000001222","DOIUrl":"https://doi.org/10.1097/pai.0000000000001222","url":null,"abstract":"OBJECTThis study aims to explore the clinical and pathologic characteristics of HPV-related primary thyroid squamous cell carcinoma (PSCCT), a rare tumor classified by WHO-5 as a subtype of anaplastic thyroid carcinoma (ATC).METHODSClinical data, histomorphology, immunohistochemistry, HPV detection, and B-raf gene point mutations of 3 PSCCT cases were analyzed. Subsequent follow-up was conducted post-treatment.RESULTSAll 3 cases involved female patients aged between 60 and 76. Microscopic examination revealed squamous cell carcinoma in cases 1 and 3, whereas case 2 exhibited both squamous cell carcinoma and papillary thyroid carcinoma components. Immunohistochemistry demonstrated CK19, PAX8, and TTF1 expression in the papillary thyroid carcinoma component, and CK5/6, p63, p40, and PAX8 expression in the squamous cell carcinoma component. P16 exhibited diffuse positivity in both squamous cell carcinoma and classic papillary carcinoma. HPV analysis identified low-risk type 6 positivity in cases 1 and 3, while both squamous cell carcinoma and papillary carcinoma areas in case 2 were positive for HPV-33. B-raf gene mutation was exclusive to case 2.CONCLUSIONDiagnosis of PSCCT necessitates multidisciplinary assessment, incorporating clinical symptoms, imaging, histomorphology, and immunohistochemistry. This study, for the first time, reveals the presence of HPV DNA in both PTC and PSCCT, occurring concurrently but separately. Given the limited scope of 3 case reports, definitive conclusions cannot be drawn, warranting further investigation.","PeriodicalId":8079,"journal":{"name":"Applied Immunohistochemistry & Molecular Morphology","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142221470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Higher Expression of Talin-1 is Associated With Less Aggressive Tumor Behavior in Pancreatic Cancer. Talin-1的高表达与胰腺癌的低侵袭性肿瘤行为有关

IF 1.6 4区医学

Applied Immunohistochemistry & Molecular Morphology Pub Date : 2024-09-11 DOI: 10.1097/pai.0000000000001220

Samira Ahmadi Jazi,Fatemeh Tajik,Fereshteh Rezagholizadeh,Seyed Reza Taha,Mahdieh Shariat Zadeh,Behnaz Bouzari,Zahra Madjd

{"title":"Higher Expression of Talin-1 is Associated With Less Aggressive Tumor Behavior in Pancreatic Cancer.","authors":"Samira Ahmadi Jazi,Fatemeh Tajik,Fereshteh Rezagholizadeh,Seyed Reza Taha,Mahdieh Shariat Zadeh,Behnaz Bouzari,Zahra Madjd","doi":"10.1097/pai.0000000000001220","DOIUrl":"https://doi.org/10.1097/pai.0000000000001220","url":null,"abstract":"Talin-1 is one of the major scaffold proteins in focal adhesions playing a vital role in cell migration, metastasis, and cancer progression. Although studies regarding the importance of Talin-1 in cancer have rapidly developed, its prognostic and diagnostic value still remain unsatisfying in pancreatic cancer (PC). Therefore, the present study aims to investigate the expression, clinical significance, as well as the prognostic and diagnostic value of Talin-1 in different types of PC. Bioinformatic analysis was applied to determine the clinical importance and biological role of Talin-1 expression in PC tumors and the normal adjacent samples. The expression patterns, clinical significance, prognosis, and diagnosis value of Talin-1 were evaluated in tissue microarrays (TMAs) of 190 PC samples including 170 pancreatic ductal adenocarcinoma (PDAC), and 20 pancreatic neuroendocrine tumors (PNET), along with 24 adjacent normal tissues using immunohistochemistry (IHC). The results indicated that the expression of Talin-1 was upregulated in tumor cells compared with adjacent normal tissues. A statistically significant association was observed between the higher cytoplasmic expression of Talin-1 and lower histologic grade (P<0.001) in PDAC samples. Further, our findings indicated an inverse significant correlation between cytoplasmic expression of Talin-1 and recurrence (P=0.014) in PNET samples. No significant association was observed between the cytoplasmic expression of Talin-1 and survival outcomes as well as diagnostic accuracy. In conclusion, our observations demonstrated that a higher cytoplasmic level of Talin-1 protein was significantly associated with less aggressive tumor behaviors in PC samples. Nevertheless, further investigations are required to explore the prognostic plus diagnostic value, and mechanism of action of Talin-1 in pancreatic cancer.","PeriodicalId":8079,"journal":{"name":"Applied Immunohistochemistry & Molecular Morphology","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142221471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0