CRC Critical reviews in immunology最新文献

The nature of the antigen-antibody bond and the factors affecting its association and dissociation. 抗原-抗体结合的性质和影响其结合和分离的因素。

CRC Critical reviews in immunology Pub Date : 1986-01-01

D R Absolom, C J van Oss

引用次数: 0

Antigen-induced B lymphocyte differentiation. 抗原诱导的B淋巴细胞分化。

CRC Critical reviews in immunology Pub Date : 1982-02-01

M C Howard

{"title":"Antigen-induced B lymphocyte differentiation.","authors":"M C Howard","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The analysis of B-lymphocyte activation has been a tantalizing prospect for both immunologists and cell biologists, as B cells have the unique characteristics of possessing a well-characterized receptor and displaying a clear inducible response to a specific antigen. As outlined in this review, we now know much about the cellular events which occur when mature B cell encounters antigen within the peripheral lymphoid organ of an immunocompetent host. Our understanding of the molecular events associated with these cellular processes is currently limited, but such information will undoubtedly ensue. The greatest challenges remaining in B-cell immunology are immunoregulation and an understanding of how the enormous B-cell specificity repertoire is generated. These challenges require greater insight into lymphocyte triggering events and the early events in B-cell maturation. This review has not restricted itself to the phenomena associated with antigen-triggered mature splenic B cells, but has attempted to include aspects of B-cell development which are often overlooked or disregarded. In particular, attention has been drawn to certain nonspecific antigen-induced B-cell events, and to antigen-initiated developmental processes which precede mature B-cell development. Additionally, the commitment of triggered mature B cells to effector cell production has been reconsidered in light of current attempts to propagate normal lymphocytes continuously and in a manner which avoids terminal differentiation. The availability of such lines, together with increasingly refined technology, will hopefully allow us to resolve the remaining mysteries in B-cell development.</p>","PeriodicalId":75750,"journal":{"name":"CRC Critical reviews in immunology","volume":"3 3","pages":"181-208"},"PeriodicalIF":0.0,"publicationDate":"1982-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17241199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Regulation of the immune response T-cell interactions. 调节免疫反应的t细胞相互作用。

CRC Critical reviews in immunology Pub Date : 1982-02-01

R W Dutton, S L Swain

引用次数: 0

Activation of the alternative complement pathway. 替代补体途径的激活。

CRC Critical reviews in immunology Pub Date : 1979-11-01

D T Fearon

引用次数: 0

Immunochemical studies on lectins and their application to the fractionation of blood group substances and cells. 凝集素的免疫化学研究及其在血型物质和细胞分馏中的应用。

CRC Critical reviews in immunology Pub Date : 1979-11-01

M E Pereira, E A Kabat

引用次数: 0