{"title":"Development and Validation of UV-Spectrophotometric Method for The Estimation of Felbinac In Marketed Formulation and Cubosomal Nano Formulation.","authors":"Sujay Hulyalkar","doi":"10.53555/ajbr.v27i3s.2060","DOIUrl":"https://doi.org/10.53555/ajbr.v27i3s.2060","url":null,"abstract":"Felbinac is the most widely preferred anti-inflammatory drug of choice and belongs to the Cox-2 inhibitor.The present study aims to develop and validate the UV-Spectrophotometric method for the estimation of Felbinac.Further, the developed UV Method was applied in the estimation of Felbinac in Marketed formulation (Traxam) and cubosomal nanoformulation.The study was performed as per ICH Guidelines and the developed UV method was validated for different parameters such as Specificity, Selectivity, Linearity, Precision (Interday, Intraday, Robustness, Ruggedness, LOD, and LOQ), and Stability study.Felbinac Showed linear response between the concentration range of 2, 4, 6, 8, and 10g/mL with an r2 value of 0.999.All the validation reports of Precision, robustness, and ruggedness were found to be within the acceptance limit.The cubosome nanoformulation of felbinac was prepared by a top-down technique using PF-127 polymer and GMO as a lipid.Cubosome nanoformulation was characterized for Particle size, Entrapment efficiency, and PDI, which were found to be 298.8nm, 81.02%, and 0.29 respectively.Drug content assay for marketed gel formulation and Cubosome showed 74.15% and 82.61% Felbinac drug content respectively.The developed UV Spectroscopic method was found to be easy, accurate, sensitive, and precise for the estimation of Felbinac in Marketed formulation and cubosomal nanoformulation.","PeriodicalId":7555,"journal":{"name":"African Journal of Biomedical Research","volume":"1 1","pages":"574-579"},"PeriodicalIF":0.0,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://africanjournalofbiomedicalresearch.com/index.php/AJBR/article/download/2060/1801/3722","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147921487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Fifty Years on: An Informetric Study of Kenya’s Health Problems, 1966–2015","authors":"O. B. Onyancha","doi":"10.4314/AJBR.V21I2","DOIUrl":"https://doi.org/10.4314/AJBR.V21I2","url":null,"abstract":"The study was aimed at identifying and mapping Kenya’s health problems between 1966 and 2015, using informetric techniques. A total of 11,028 journal articles were extracted from the MEDLINE database and analysed using various computer-aided software. Results indicate that the most problematic health issue as covered in the biomedical and health literature in Kenya is HIV/AIDS, followed by malaria and tuberculosis; the most researched and therefore affected age group is young adults aged between 19 and 44 years; most research target problems associated with the female population. There were strong correlations between the government of Kenya’s efforts in improving health and the volume of research; and there were weak and insignificant correlations between the burden of disease and the volume of research. The findings give credence to the effect that informetrics can be used to assess health problems in a given country. Keywords : Informetrics, Health problems, Medical research, Health research Kenya, Research evaluation","PeriodicalId":7555,"journal":{"name":"African Journal of Biomedical Research","volume":"47 1","pages":"107-115"},"PeriodicalIF":0.0,"publicationDate":"2018-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81800772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}