发布求助
文献互助 智能选刊 最新文献

Recent patents on biomarkers最新文献

筛选
英文 中文
Detection of Lysyl Oxidase-Like 2 (LOXL2), a Biomarker of Metastasis from Breast Cancers Using Human Blood Samples. 利用人血样本检测乳腺癌转移标志物赖氨酸氧化酶样2 (LOXL2)
Recent patents on biomarkers Pub Date : 2015-01-01 DOI: 10.2174/2210309005666150804195033
Metini Janyasupab, Ying-Hui Lee, Yuan Zhang, Chen W Liu, Jieyi Cai, Adriana Popa, Anna C Samia, Kuan W Wang, Jiaqiang Xu, Chi-Chang Hu, Michael K Wendt, Barbara J Schiemann, Cheryl L Thompson, Yun Yen, William P Schiemann, Chung C Liu
{"title":"Detection of Lysyl Oxidase-Like 2 (LOXL2), a Biomarker of Metastasis from Breast Cancers Using Human Blood Samples.","authors":"Metini Janyasupab,&nbsp;Ying-Hui Lee,&nbsp;Yuan Zhang,&nbsp;Chen W Liu,&nbsp;Jieyi Cai,&nbsp;Adriana Popa,&nbsp;Anna C Samia,&nbsp;Kuan W Wang,&nbsp;Jiaqiang Xu,&nbsp;Chi-Chang Hu,&nbsp;Michael K Wendt,&nbsp;Barbara J Schiemann,&nbsp;Cheryl L Thompson,&nbsp;Yun Yen,&nbsp;William P Schiemann,&nbsp;Chung C Liu","doi":"10.2174/2210309005666150804195033","DOIUrl":"https://doi.org/10.2174/2210309005666150804195033","url":null,"abstract":"<p><p>Metastasis accounts for 90% of the mortality associated with breast cancer. Upregulated expression of members of the lysyl oxidase (LOX) family of secreted copper amine oxidases catalyzes the crosslinking of collagens and elastin in the extracellular matrix. LOXs are linked to the development and metastatic progression of breast cancers. Accordingly, aberrant expression of LOX-like 2 (LOXL2) is observed in poorly differentiated, high-grade tumors and is predictive of diseases recurrence, and for decreased overall patient survival. Therefore, LOXL2 expression may serve as a biomarker for breast cancer. Mechanistically, hydrogen peroxide is produced as a byproduct of LOXL2 when using an appropriate substrate, lysine. We exploited this chemistry to generate a revolutionary gold-based electrochemical biosensor capable of accurately detecting nanomolar quantities of LOXL2 in mouse blood, and in human blood samples. Two different sources of the blood samples obtained from breast cancer patients were used in this study indicating the applicability of detecting LOXL2 in breast cancers patients. Limited numbers of urine specimens from breast cancer patients were also tested. Collectively, all of these tests show the promise and potential of this biosensor for detecting LOXL2 as a surrogate biomarker of breast cancer. This work is described in WO 052962 A1 (2014).</p>","PeriodicalId":74645,"journal":{"name":"Recent patents on biomarkers","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5493150/pdf/nihms857765.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9932531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 14
Role of Netrin-1 Beyond the Brain: From Biomarker of Tissue Injury to Therapy for Inflammatory Diseases. Netrin-1在脑外的作用:从组织损伤的生物标志物到炎症性疾病的治疗。
Recent patents on biomarkers Pub Date : 2012-09-01 DOI: 10.2174/2210309011202030202
Ganesan Ramesh
{"title":"Role of Netrin-1 Beyond the Brain: From Biomarker of Tissue Injury to Therapy for Inflammatory Diseases.","authors":"Ganesan Ramesh","doi":"10.2174/2210309011202030202","DOIUrl":"https://doi.org/10.2174/2210309011202030202","url":null,"abstract":"<p><p>Acute kidney injury (AKI) is a common problem in the hospital setting and intensive care unit. Despite improved understanding, there are no effective therapies available to treat AKI. AKI is often diagnosed late and, therefore, identification of a biomarker that will facilitate early diagnosis of AKI and provide a prognosis is desirable. The recent identification of a novel biomarker, netrin-1, that is capable of diagnosing early during the course of kidney injury has created much interest in this molecule. In this paper, we review recent progress made in understanding netrin-1 as a biomarker and therapeutic molecule for acute and chronic kidney diseases. We also discuss both the usefulness of netrin-1 as a biomarker of other diseases and as a possible therapeutic agent and relevant patents for inflammatory diseases.</p>","PeriodicalId":74645,"journal":{"name":"Recent patents on biomarkers","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2012-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3517172/pdf/nihms415901.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31113551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 20
Approaches to the Management of Acute Kidney Injury in Children. 处理儿童急性肾损伤的方法。
Recent patents on biomarkers Pub Date : 2011-01-01
Rajit K Basu, Derek S Wheeler
{"title":"Approaches to the Management of Acute Kidney Injury in Children.","authors":"Rajit K Basu, Derek S Wheeler","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Acute kidney injury (AKI) causes increased morbidity in critically ill children and damage to the kidney, a central mediator of homeostasis in the body, affects survival. The incidence of AKI in pediatrics is significant and despite alarming data, therapeutic interventions have failed to effect a meaningful difference in outcomes. In this review, we will discuss the epidemiology of AKI in pediatrics, treatment strategies attempted to date, experimental therapies targeting molecular patterns associated with AKI, and highlight the needed direction of AKI research and management. Prospective trials in pediatrics are needed to test the validity of diagnostic tools, to identify the point of most efficacious intervention, and to underscore the therapies that can be effective in the different downstream effects of AKI.</p>","PeriodicalId":74645,"journal":{"name":"Recent patents on biomarkers","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3607497/pdf/nihms-300455.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40233292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Approaches to the Management of Acute Kidney Injury in Children. 儿童急性肾损伤的处理方法。
Recent patents on biomarkers Pub Date : 2011-01-01 DOI: 10.2174/2210309011101010049
Rajit K. Basu, D. Wheeler
{"title":"Approaches to the Management of Acute Kidney Injury in Children.","authors":"Rajit K. Basu, D. Wheeler","doi":"10.2174/2210309011101010049","DOIUrl":"https://doi.org/10.2174/2210309011101010049","url":null,"abstract":"Acute kidney injury (AKI) causes increased morbidity in critically ill children and damage to the kidney, a central mediator of homeostasis in the body, affects survival. The incidence of AKI in pediatrics is significant and despite alarming data, therapeutic interventions have failed to effect a meaningful difference in outcomes. In this review, we will discuss the epidemiology of AKI in pediatrics, treatment strategies attempted to date, experimental therapies targeting molecular patterns associated with AKI, and highlight the needed direction of AKI research and management. Prospective trials in pediatrics are needed to test the validity of diagnostic tools, to identify the point of most efficacious intervention, and to underscore the therapies that can be effective in the different downstream effects of AKI.","PeriodicalId":74645,"journal":{"name":"Recent patents on biomarkers","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68161364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 13
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：481959085
Book学术官方微信