Neurons and neurological disorders最新文献

Exploratory Model of Collaboration Networks in the COVID-19 Era 新冠肺炎时代协同网络的探索性模型

Neurons and neurological disorders Pub Date : 2023-03-09 DOI: 10.58489/2836-8851/009

C. García-Lirios

引用次数: 0

Prooxidant-Antioxidant Balance of The Brain of Rats with Cerebral Ischemia with The Introduction Of L-Name, L-Arginine, And Omega-3 Polyunsaturated Fatty Acids 引入L-Name、l -精氨酸和Omega-3多不饱和脂肪酸对脑缺血大鼠大脑促氧化-抗氧化平衡的影响

Neurons and neurological disorders Pub Date : 2023-03-09 DOI: 10.58489/2836-8851/008

Lizaveta I. Bon

{"title":"Prooxidant-Antioxidant Balance of The Brain of Rats with Cerebral Ischemia with The Introduction Of L-Name, L-Arginine, And Omega-3 Polyunsaturated Fatty Acids","authors":"Lizaveta I. Bon","doi":"10.58489/2836-8851/008","DOIUrl":"https://doi.org/10.58489/2836-8851/008","url":null,"abstract":"The search for new approaches to the treatment of acute ischemic stroke is one of the urgent problems of experimental and clinical neurology. This is due to the fact that cerebrovascular diseases of ischemic origin tend to grow, rejuvenate, are associated with a severe clinical course, high rates of disability and mortality. One of the promising neuroprotective amino acids is L-arginine. Most of the effects caused by this amino acid are associated with its ability to increase the formation of NO, acting as a source for its formation. An important role of ω-3 polyunsaturated fatty acids (Omega-3 PUFAs) is to ensure the functioning of cell membranes, transmembrane ion channels and the regulation of physiological processes through the synthesis of lipid mediators, which, lining up in the phospholipid layer of cell membranes, affect their fluidity. Cerebral ischemia is characterized by the activation of prooxidant mechanisms, as well as the inhibition of energy metabolism in the brain tissue. The introduction of the drug «Omega-3 PUFA» has a corrective effect on the indicators of oxidative stress in SCI. The use of «Omega-3 PUFA» in animals of the group with cerebral ischemia and the introduction of a non-selective NOS inhibitor – L-NAME did not have a positive effect.","PeriodicalId":74288,"journal":{"name":"Neurons and neurological disorders","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88817580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The second case of Bardet-Biedl syndrome from Iraq: An educational article and expert opinion 伊拉克第二例baret - biedl综合征:一篇教育文章和专家意见

Neurons and neurological disorders Pub Date : 2023-03-09 DOI: 10.58489/2836-8851/010

Aamir Jalal Al-Mosawi

{"title":"The second case of Bardet-Biedl syndrome from Iraq: An educational article and expert opinion","authors":"Aamir Jalal Al-Mosawi","doi":"10.58489/2836-8851/010","DOIUrl":"https://doi.org/10.58489/2836-8851/010","url":null,"abstract":"Background: Bardet-Biedl syndrome and Laurence-Moon syndrome are rare autosomal recessive disorders with a similar phenotype. They are characterized by the gradual development of phenotype which includes cone-rod retinal dystrophy, obesity, and hypogonadism in males. Other associated abnormalities include learning disability and renal abnormalities. The two conditions are differentiated clinically by the presence of spasticity and the absence of polydactyly in Laurence-Moon syndrome. In 2002, we reported the first patient with Bardet-Biedl syndrome. The boy had polydactyly, obesity, retinal degeneration, and was hospitalized at the University Hospital in Al-Kadhimiyia because of the development of chronic renal failure. Patients and methods: The case of a 9-year-old obese Kurdish girl who had polydactyly of the hands and feet associated with reduced visual acuity is described. Results: A 9-year-old obese Kurdish girl had polydactyly of the hand and feet associated with reduced visual acuity that was attributed to myopia which was partially corrected with eye glasses. The parents were unrelated, and her younger 5-year sister had polydactyly of the feet only. No other family member known to have polydactyly. Both sisters had their extra-digits removed surgically. The girl was studying at fourth grade primary school and the parents reported no learning disability. Fundoscopy showed normal optic disc and periphery of the retina. The presence of retinitis pigmentosa was excluded. However, the foveal reflex was reported to be abnormal by the oophthalmologist. Electroretinography showed evidence of cone-rod dystrophy. Conclusion: The second case of Bardet-Biedl syndrome from Iraq is reported. The current evidence-based expert opinion suggests the use of long tem supplementation of citicoline, co-enzyme Q10 and lutein with hope of retarding the progression to blindness.","PeriodicalId":74288,"journal":{"name":"Neurons and neurological disorders","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81511668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Unified Theory of Medicine 医学统一理论

Neurons and neurological disorders Pub Date : 2022-12-27 DOI: 10.58489/2836-8851/006

Lewis S. Coleman

引用次数: 0

Perspectives and trends in research ethics: A necessity 研究伦理的观点和趋势:一种必要性

Neurons and neurological disorders Pub Date : 2022-12-27 DOI: 10.58489/2836-8851/007

N. Johnkennedy

引用次数: 0

Analysis Of the Psychological State of People During the Covid - 19 Pandemic 新冠肺炎疫情期间民众心理状态分析

Neurons and neurological disorders Pub Date : 2022-12-21 DOI: 10.58489/2836-8851/001

K. M. Chandran

{"title":"Analysis Of the Psychological State of People During the Covid - 19 Pandemic","authors":"K. M. Chandran","doi":"10.58489/2836-8851/001","DOIUrl":"https://doi.org/10.58489/2836-8851/001","url":null,"abstract":"The COVID-19 pandemic could have affected people not only physically, but also psychologically. It is in this background that this study was undertaken by WEDO (NGO), Kozhikode, Kerala, India. Data was collected on-line using a questionnaire containing 15 psychological traits and their level of experience, and the characteristics of respondents such as age, sex, education etc. from a sample of 300 respondents from India using the snow ball sampling technique. The total score of the traits was worked out as the psychological state score. The data was analyzed as proportion / score and through statistical tests. The COVID-19 pandemic has influenced the psychology of the respondents negatively. The influence of existing tension of people in creating more tension during the pandemic period is evident from the study. Random Forest technique results show that Enthusiasm, Satisfaction, Loving nature and Peacefulness are the main psychological traits, which influence the personality state score. The characteristics of respondents such as age, education, pre COVID tension and pre COVID tension affecting the tension during the pandemic period are found to influence the personality score statistically through Chi-square test. Odds ratio test shows that respondents with PG qualification have about 4.62 times more chance of maintaining a better psychological state during the pandemic period than less educated people. Males have 1.16 times more chance of maintaining a better psychological state than females. The study has revealed the negative effect of the COVID-19 pandemic on the psychological state of people, with majority attributing this to the pandemic itself.","PeriodicalId":74288,"journal":{"name":"Neurons and neurological disorders","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88507902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mental and Physical Symptoms of Alcohol Hangover 酒精宿醉的精神和身体症状

Neurons and neurological disorders Pub Date : 2022-12-21 DOI: 10.58489/2836-8851/004

Gudisa Bereda

{"title":"Mental and Physical Symptoms of Alcohol Hangover","authors":"Gudisa Bereda","doi":"10.58489/2836-8851/004","DOIUrl":"https://doi.org/10.58489/2836-8851/004","url":null,"abstract":"Alcohol hangover can be defined as the combination of mental and physical symptoms that are experienced the day after an episode of heavy alcohol drinking, launching when blood alcohol concentration approaches zero and characterized by the constellation of unpleasant physical and mental symptoms that occur after heavy alcohol drinking. Significant changes observed on endocrine parameters (elevated concentrations of vasopressin, aldosterone, and renin) and metabolic acidosis (lowered blood potential hydrogen values due to elevated concentrations of lactate, ketone bodies, and free fatty acids) occurred during hangover and eventually causes dehydration and symptoms such as dry mouth and thirst. Females have more body fat and less water than men of the same body weight. Since alcohol is dispensed in body water, women reach higher blood alcohol concentrations levels than men despite consuming an identical number of alcohol units. Alcohol gets metabolized to an intermediate product, acetaldehyde, by the enzyme alcohol dehydrogenase, and then acetaldehyde is converted to acetate by a second enzyme aldehyde dehydrogenase. Acetaldehyde at higher concentrations causes toxic effects, such as rapid pulse, sweating, skin flushing, nausea, and vomiting. In most people, aldehyde dehydrogenase metabolizes acetaldehyde quickly and efficiently, so that this intermediate metabolite does not accumulate in high concentrations.","PeriodicalId":74288,"journal":{"name":"Neurons and neurological disorders","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73620268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative Analysis of Combination Therapy Regimens in Patients with Paranoid Schizophrenia with Non-Suicidal Auto aggression and Identified Signs of Resistance to Ongoing Neuroleptic Monotherapy 偏执型精神分裂症伴非自杀性自身攻击患者联合治疗方案的比较分析及对持续抗精神病药单一治疗的抗性迹象

Neurons and neurological disorders Pub Date : 2022-12-21 DOI: 10.58489/2836-8851/005

Kravchenko I.V.

{"title":"Comparative Analysis of Combination Therapy Regimens in Patients with Paranoid Schizophrenia with Non-Suicidal Auto aggression and Identified Signs of Resistance to Ongoing Neuroleptic Monotherapy","authors":"Kravchenko I.V.","doi":"10.58489/2836-8851/005","DOIUrl":"https://doi.org/10.58489/2836-8851/005","url":null,"abstract":"A comparative analysis of combination therapy regimens was carried out in patients with paranoid schizophrenia with NSAA and identified signs of resistance to ongoing neuroleptic monotherapy. In total, in the period from 2015 to 2022, 155 patients with paranoid schizophrenia with NSAA were studied as part of a multicenter randomized longitudinal study. It has been established that the first-line therapy regimen in this group of patients is a combined regimen of clozapine with haloperidol. Introduction. The increase in the number of therapeutically resistant patients with paranoid schizophrenia with auto aggression remains one of the most pressing problems in psychiatry remains as the most common nosological unit [1,2,3]. At the same time, a large amount of research material has been accumulated on the factors and conditions that affect the formation of the state of resistance in such patients [4,5,6,7]. First of all, these include: a debut at an early age, an \"erased\" beginning, a continuous course, the dominance of negative symptoms in the structure of the pathological process, and the fading of the affective component. A special place among the clinical predictors of therapeutic resistance is occupied by psychopathic disorders with auto aggressive tendencies, traditionally considered within the framework of heboid states. At the same time, until recently, the main drug from the group of neuroleptics used to overcome resistance was clozapine [8,9,10,11,12,13]. In practice, up to 30% of patients remain intact to its action, which dictates the need for combination therapy [14,15,16]. This predetermines the search for new schemes for the use of medicinal drugs to solve this problem.","PeriodicalId":74288,"journal":{"name":"Neurons and neurological disorders","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85679216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Innovation in Neurosurgery: Lessons Learned, Obstacles, and Potential Funding Sources 神经外科的创新:经验教训、障碍和潜在的资金来源

Neurons and neurological disorders Pub Date : 2022-12-19 DOI: 10.1055/s-0043-1762321

C. Cutler, P. King, Majid Khan, Bankole Olowofela, B. Lucke-Wold

引用次数: 0

Innovation in Neurosurgery: Lessons Learned, Obstacles, and Potential Funding Sources. 神经外科的创新：经验教训、障碍和潜在资金来源。

Neurons and neurological disorders Pub Date : 2022-01-01 Epub Date: 2022-12-19

Christopher B Cutler, Patrick King, Majid Khan, Bankole Olowofela, Brandon Lucke-Wold

引用次数: 0