{"title":"The Diagnostic Value of Neutrophil to Lymphocyte Ratio as an Effective Biomarker for Neuromyelitis Optica Spectrum Disorder.","authors":"Navid Fazlinejad, Samaneh Hosseini, Shirin Yaghoobpoor, Mina Dehghani, Hanieh Bazrafshan, Shokoufeh Khanzadeh, Brandon Lucke-Wold","doi":"10.33696/rehabilitation.5.035","DOIUrl":"10.33696/rehabilitation.5.035","url":null,"abstract":"<p><strong>Background: </strong>Neuromyelitis Optica (NMO) is a serious condition associated with inflammation. Early diagnosis and detection are critical for early intervention. In this systematic review, we investigate the role of the neutrophil to lymphocyte ratio (NLR) as an important biomarker for NMO.</p><p><strong>Methods: </strong>Ten studies were selected that were sufficiently high quality and then checked for quality. The studies were organized by English language and selective inclusion criteria.</p><p><strong>Results: </strong>NLR was significantly increased in NMO patients compared to controls. The ratio was specifically proportional to severity of disease. More severe disease had a higher ratio.</p><p><strong>Conclusion: </strong>NLR offers a reliable and affordable method for early detection of disease severity. This can help guide appropriate treatment selection and monitor treatment response.</p>","PeriodicalId":73900,"journal":{"name":"Journal of physical medicine and rehabilitation (Wilmington, Del.)","volume":"5 1","pages":"16-25"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10207151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Use of Consumer Wearable Physical Activity Monitors in Clinical Populations with Functional Limitations","authors":"Julian Martinez, Taylor M. Gordon, S. Strath","doi":"10.33696/rehabilitation.3.022","DOIUrl":"https://doi.org/10.33696/rehabilitation.3.022","url":null,"abstract":"Functionally limiting health conditions have a high rate of prevalence worldwide and incur a significant amount of economic burden. Physical activity (PA) can prevent the onset of these conditions and alleviate economic burden by reducing symptoms, but a large portion of these individuals do not engage in health enhancing PA. Consumer wearable physical activity monitors (WPAM) are tools that have become increasingly popular within the past few years and could provide a means to improve PA levels for individuals with health conditions that cause functional limitations. This review reports on the validity of PA outcomes, feasibility and utility, and intervention/promotion effectiveness for consumer WPAM in functionally limited clinical populations. 2250 records from January 2018 to July 2021 were retrieved from PubMed, Web of Science, SPORTDiscus and CINAHL with 656 records being duplicates and 23 records passing a full-text article review. Studies included within the review looked at individuals with osteoarthritis, rheumatoid arthritis, axial spondyloarthritis, multiple sclerosis, Parkinson’s disease, ischemic stroke and peripheral arterial disease. The most popular brand of consumer WPAM was Fitbit. Validation studies for consumer WPAM were primarily focused on step counts showing overestimations for daily step counts and over- and under-estimations occurring within shorter time durations depending on step cadence. Wrist worn WPAM are the most feasible for functionally limited clinical populations with widespread utilization for associating clinically relevant outcomes with PA levels but they have limited validation to confirm their accuracy and precision in measurement. Interventions included used a mixture of a WPAM and other behavior change techniques to improve PA levels for clinical populations and show promising effectiveness. Future work is warranted on determining the validity of PA outcomes from WPAM determined to be feasible in select clinical populations and creating interventions looking at which features of a consumer WPAM intervention promote PA.","PeriodicalId":73900,"journal":{"name":"Journal of physical medicine and rehabilitation (Wilmington, Del.)","volume":"17 1","pages":"73 - 90"},"PeriodicalIF":0.0,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90244576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
T. Dillingham, J. Kenia, A. Popescu, C. Plastaras, S. Becker, F. Shofer
{"title":"Pain Outcomes with an Elliptical Regimen (POWER) Study: Identifying the Proper Dosage of Exercise for Therapeutic Effect in Persons with Chronic Back Pain","authors":"T. Dillingham, J. Kenia, A. Popescu, C. Plastaras, S. Becker, F. Shofer","doi":"10.33696/REHABILITATION.2.011","DOIUrl":"https://doi.org/10.33696/REHABILITATION.2.011","url":null,"abstract":"Background context: Exercise therapy for low back pain has long been prescribed as one of the initial remedies for back pain. Traditional therapy is completed under a therapist’s supervision and consists of lumbar stabilization, aerobic exercise and stretching exercises. Recent studies have explored treating back pain with aerobic exercise such as walking which can be done anywhere and without supervision which is lower cost and easily administered. Purpose: To assess a therapeutic dosage of aerobic exercise that is associated with pain reduction in persons experiencing low back pain. Study design: Case series. Participant description: Sixteen patients entered the study and twelve patients completed the study (mean ± SD: age 51 ± 11 years; weight 89.2 ± 16 kg). Subjects were included if they were ages 18–65, had chronic back pain lasting for more than 3 months and a score of greater than 30% on the Oswestry Low Back Disability Questionnaire. Methods: Subjects underwent a six-week exercise program using the elliptical trainer three times each week. Exercise duration was steadily increased each week for the length of the study. The total cumulative amount of work that coincided with significant reductions in chronic low back pain was then identified. Results: At 4 weeks, pain scores were significantly reduced from baseline (3.2 vs 4.7, p<0.0001). This significant pain reduction corresponded to an average of 30.8 Kcal/kg of body mass in cumulative work performed. Pain was significantly reduced by 21% and 32% on the Oswestry Questionnaire and the PROMIS 29 respectively. Conclusions: These pilot findings suggest that approximately 30.8 kcal/Kg of accumulated physiological work is a therapeutic “dosage” of exercise needed for significant reduction in chronic back pain. Clinicians can begin to use this benchmark for their oversight of rehabilitation programs to determine if an exercise program has been sufficiently intense and long enough in duration for managing their patients with chronic low back pain.","PeriodicalId":73900,"journal":{"name":"Journal of physical medicine and rehabilitation (Wilmington, Del.)","volume":"28 1","pages":"23 - 28"},"PeriodicalIF":0.0,"publicationDate":"2020-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84542824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Energy Expenditure and Nutrition in Neurogenic Obesity following Spinal Cord Injury.","authors":"Gary J Farkas, David R Gater","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":73900,"journal":{"name":"Journal of physical medicine and rehabilitation (Wilmington, Del.)","volume":"2 1","pages":"11-13"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7100891/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37783459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Timothy Dillingham, Jessica Kenia, Adrian Popescu, Christopher Plastaras, Scott Becker, Frances Shofer
{"title":"Pain Outcomes with an Elliptical Regimen (POWER) Study: Identifying the Proper Dosage of Exercise for Therapeutic Effect in Persons with Chronic Back Pain.","authors":"Timothy Dillingham, Jessica Kenia, Adrian Popescu, Christopher Plastaras, Scott Becker, Frances Shofer","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background context: </strong>Exercise therapy for low back pain has long been prescribed as one of the initial remedies for back pain. Traditional therapy is completed under a therapist's supervision and consists of lumbar stabilization, aerobic exercise and stretching exercises. Recent studies have explored treating back pain with aerobic exercise such as walking which can be done anywhere and without supervision which is lower cost and easily administered.</p><p><strong>Purpose: </strong>To assess a therapeutic dosage of aerobic exercise that is associated with pain reduction in persons experiencing low back pain.</p><p><strong>Study design: </strong>Case series.</p><p><strong>Participant description: </strong>Sixteen patients entered the study and twelve patients completed the study (mean ± SD: age 51 ± 11 years; weight 89.2 ± 16 kg). Subjects were included if they were ages 18-65, had chronic back pain lasting for more than 3 months and a score of greater than 30% on the Oswestry Low Back Disability Questionnaire.</p><p><strong>Methods: </strong>Subjects underwent a six-week exercise program using the elliptical trainer three times each week. Exercise duration was steadily increased each week for the length of the study. The total cumulative amount of work that coincided with significant reductions in chronic low back pain was then identified.</p><p><strong>Results: </strong>At 4 weeks, pain scores were significantly reduced from baseline (3.2 vs 4.7, p<0.0001). This significant pain reduction corresponded to an average of 30.8 Kcal/kg of body mass in cumulative work performed. Pain was significantly reduced by 21% and 32% on the Oswestry Questionnaire and the PROMIS 29 respectively.</p><p><strong>Conclusions: </strong>These pilot findings suggest that approximately 30.8 kcal/Kg of accumulated physiological work is a therapeutic \"dosage\" of exercise needed for significant reduction in chronic back pain. Clinicians can begin to use this benchmark for their oversight of rehabilitation programs to determine if an exercise program has been sufficiently intense and long enough in duration for managing their patients with chronic low back pain.</p>","PeriodicalId":73900,"journal":{"name":"Journal of physical medicine and rehabilitation (Wilmington, Del.)","volume":"2 2","pages":"23-28"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7377601/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38189083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Energy Expenditure and Nutrition in Neurogenic Obesity following Spinal Cord Injury","authors":"G. Farkas, D. Gater","doi":"10.33696/REHABILITATION.2.008","DOIUrl":"https://doi.org/10.33696/REHABILITATION.2.008","url":null,"abstract":"Worldwide, obesity is a public health concern and a metabolic ailment characterized by excessive adipose tissue accumulation resulting from an imbalance of energy expenditure and energy intake [1]. This disorder is a known risk factor for cardiovascular disease, type 2 diabetes mellitus, dyslipidemia, hypertension, and metabolic syndrome, and in recent years, it has been described as a systemic inflammatory disease with chronic consequences [2].","PeriodicalId":73900,"journal":{"name":"Journal of physical medicine and rehabilitation (Wilmington, Del.)","volume":"36 1","pages":"11 - 13"},"PeriodicalIF":0.0,"publicationDate":"2019-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82069853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}