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International journal of pharmacokinetics最新文献

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Intersex and interspecies pharmacokinetics of metoprolol after oral and intravenous dose administration in rats and mice 美托洛尔在大鼠和小鼠体内口服和静脉给药后的雌雄和种间药代动力学
International journal of pharmacokinetics Pub Date : 2023-03-03 DOI: 10.4155/ipk-2022-0002
Yeshwant Singh, Ravi Akkireddy, Deepti Sahu, Giridhar Bilagi, Theertha Thykandy, Prajakta Hingole, Deveshkumar Rana, Roopa Naraganti, Sudhir Kumar Tiwari, P. Srivastava
{"title":"Intersex and interspecies pharmacokinetics of metoprolol after oral and intravenous dose administration in rats and mice","authors":"Yeshwant Singh, Ravi Akkireddy, Deepti Sahu, Giridhar Bilagi, Theertha Thykandy, Prajakta Hingole, Deveshkumar Rana, Roopa Naraganti, Sudhir Kumar Tiwari, P. Srivastava","doi":"10.4155/ipk-2022-0002","DOIUrl":"https://doi.org/10.4155/ipk-2022-0002","url":null,"abstract":"Aim: Intersex and interspecies metoprolol pharmacokinetics following intravenous and oral dose administration in rodents. Materials & methods: Oral and intravenous dose studies were conducted in rats and mice. Significant intersex differences were observed in peak plasma levels of metoprolol after oral dose in both the species. The plasma concentration (Cmax) was approximately sevenfold higher (270.356 ng/ml) in female compared with male rats (40.981 ng/ml) following oral dose administration. The Cmax observed for male (878.822 ± 75.5 ng/ml) was approximately twofold higher than in female mouse (404.016 ± 113.5 ng/ml) after oral dose administration. Conclusion: Sex and species related physioanatomical characteristics alters metoprolol pharmacokinetics. Such differences should be addressed in studies related to metoprolol interactions with concurrently administered drug candidates.","PeriodicalId":73468,"journal":{"name":"International journal of pharmacokinetics","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84264926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association between simulated ketamine exposures and oxygen saturations in children. 模拟氯胺酮暴露与儿童血氧饱和度之间的关系。
International journal of pharmacokinetics Pub Date : 2023-02-01 DOI: 10.4155/ipk-2022-0003
Sarah Jane Commander, Daniel Gonzalez, Karan R Kumar, Tracy Spears, Michael Cohen-Wolkowiez, Kanecia O Zimmerman, Jan Hau Lee, Christoph P Hornik
{"title":"Association between simulated ketamine exposures and oxygen saturations in children.","authors":"Sarah Jane Commander,&nbsp;Daniel Gonzalez,&nbsp;Karan R Kumar,&nbsp;Tracy Spears,&nbsp;Michael Cohen-Wolkowiez,&nbsp;Kanecia O Zimmerman,&nbsp;Jan Hau Lee,&nbsp;Christoph P Hornik","doi":"10.4155/ipk-2022-0003","DOIUrl":"https://doi.org/10.4155/ipk-2022-0003","url":null,"abstract":"<p><strong>Aim: </strong>We performed a real-world data analysis to evaluate the relationship between simulated ketamine exposures and oxygen desaturation in children.</p><p><strong>Materials & methods: </strong>A previously developed population pharmacokinetic model was used to simulate exposures and evaluate target attainment, as well as the association with oxygen desaturation in children ≤17 years treated with intravenous ketamine.</p><p><strong>Results: </strong>In 2022 children, there was no significant association between simulated plasma ketamine concentrations and oxygen saturation; however, a higher cumulative area under the curve was associated with increased odds of progression to significant desaturation (<85%), though magnitude of effect was small.</p><p><strong>Conclusion: </strong>By leveraging a population pharmacokinetic model and real-world data, we confirmed there is no relationship between simulated ketamine plasma concentration and oxygen desaturation.</p>","PeriodicalId":73468,"journal":{"name":"International journal of pharmacokinetics","volume":"6 1","pages":"IPK03"},"PeriodicalIF":0.0,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9996394/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9454753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bayesian therapeutic drug monitoring software: past, present and future 贝叶斯治疗药物监测软件:过去，现在和未来
International journal of pharmacokinetics Pub Date : 2018-12-01 DOI: 10.4155/IPK-2018-0005
P. Drennan, M. Doogue, S. V. Hal, P. Chin
{"title":"Bayesian therapeutic drug monitoring software: past, present and future","authors":"P. Drennan, M. Doogue, S. V. Hal, P. Chin","doi":"10.4155/IPK-2018-0005","DOIUrl":"https://doi.org/10.4155/IPK-2018-0005","url":null,"abstract":"","PeriodicalId":73468,"journal":{"name":"International journal of pharmacokinetics","volume":"47 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4155/IPK-2018-0005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72533751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 19
Personalized medicine in digital innovation 数字化创新中的个性化医疗
International journal of pharmacokinetics Pub Date : 2018-11-30 DOI: 10.4155/IPK-2018-0006
Kairui Feng, R. Leary
{"title":"Personalized medicine in digital innovation","authors":"Kairui Feng, R. Leary","doi":"10.4155/IPK-2018-0006","DOIUrl":"https://doi.org/10.4155/IPK-2018-0006","url":null,"abstract":"","PeriodicalId":73468,"journal":{"name":"International journal of pharmacokinetics","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88851004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Pharmacokinetic–pharmacodynamic modeling and it is relevance in the drug discovery 药代动力学-药效学建模及其与药物发现的相关性
International journal of pharmacokinetics Pub Date : 2018-09-01 DOI: 10.4155/IPK-2018-0004
S. Dubey, K. S. Pradyuth, Sreehari Krishna Kulkarni, Gautam Singhvi
{"title":"Pharmacokinetic–pharmacodynamic modeling and it is relevance in the drug discovery","authors":"S. Dubey, K. S. Pradyuth, Sreehari Krishna Kulkarni, Gautam Singhvi","doi":"10.4155/IPK-2018-0004","DOIUrl":"https://doi.org/10.4155/IPK-2018-0004","url":null,"abstract":"","PeriodicalId":73468,"journal":{"name":"International journal of pharmacokinetics","volume":"63 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87028645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
On the reproducibility crisis in nanomedicine: an interview with Sourav Bhattacharjee 关于纳米医学的可再现性危机:采访Sourav Bhattacharjee
International journal of pharmacokinetics Pub Date : 2018-09-01 DOI: 10.4155/IPK-2018-0007
S. Bhattacharjee
{"title":"On the reproducibility crisis in nanomedicine: an interview with Sourav Bhattacharjee","authors":"S. Bhattacharjee","doi":"10.4155/IPK-2018-0007","DOIUrl":"https://doi.org/10.4155/IPK-2018-0007","url":null,"abstract":"Biography Sourav Bhattacharjee is a physician (MBBS) and graduated from Medical College and Hospital Kolkata (India). After postgraduate residential training in orthopedic surgery, he finished MSc in Biomolecular Sciences/Cell Biology from the Vrije Universiteit Amsterdam (2006–2008). His MSc thesis work was done in the Napier University (Edinburgh, UK). He began his PhD in the Wageningen University (The Netherlands) in 2008, which he successfully defended in 2012. Following that he worked for almost a year as postdoc in the University of Twente (The Netherlands). From March 2014, he joined UCD (Ireland) as postdoc trying to develop nanoparticulate platforms for oral insulin delivery as part of EU FP7 funded TRANS-INT consortium. From February 2016, he was appointed as Assistant Professor in the UCD where he is engaged now in developing a broad range of advanced nanobiotechnology-based and microscopic tools for effective diagnostic and therapeutic purposes in various diseases.","PeriodicalId":73468,"journal":{"name":"International journal of pharmacokinetics","volume":"38 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78074886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Extrapolation of pharmacokinetic interaction data of proton pump inhibitors obtained in healthy subjects for oral targeted therapies in cancer patients 质子泵抑制剂在健康受试者中口服靶向治疗癌症患者的药代动力学相互作用数据的外推
International journal of pharmacokinetics Pub Date : 2018-09-01 DOI: 10.4155/IPK-2018-0003
N. Srinivas
{"title":"Extrapolation of pharmacokinetic interaction data of proton pump inhibitors obtained in healthy subjects for oral targeted therapies in cancer patients","authors":"N. Srinivas","doi":"10.4155/IPK-2018-0003","DOIUrl":"https://doi.org/10.4155/IPK-2018-0003","url":null,"abstract":"","PeriodicalId":73468,"journal":{"name":"International journal of pharmacokinetics","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88051130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The importance of clinical pharmacokinetic-pharmacodynamic studies in unraveling the determinants of early and late tuberculosis outcomes. 临床药代动力学-药效学研究在揭示早期和晚期结核预后决定因素中的重要性。
International journal of pharmacokinetics Pub Date : 2017-08-01 Epub Date: 2017-07-12 DOI: 10.4155/ipk-2017-0004
Andrew D McCallum, Derek J Sloan
{"title":"The importance of clinical pharmacokinetic-pharmacodynamic studies in unraveling the determinants of early and late tuberculosis outcomes.","authors":"Andrew D McCallum,&nbsp;Derek J Sloan","doi":"10.4155/ipk-2017-0004","DOIUrl":"https://doi.org/10.4155/ipk-2017-0004","url":null,"abstract":"<p><p>Tuberculosis remains a major infectious cause of morbidity and mortality worldwide. Current antibiotic regimens, constructed prior to the development of modern pharmacokinetic-pharmacodynamic (PK-PD) tools, are based on incomplete understanding of exposure-response relationships in drug susceptible and multidrug resistant tuberculosis. Preclinical and population PK data suggest that clinical PK-PD studies may enable therapeutic drug monitoring for some agents and revised dosing for others. Future clinical PK-PD challenges include: incorporation of PK methods to assay free concentrations for all active metabolites; selection of appropriate early outcome measures which reflect therapeutic response; elucidation of genetic contributors to interindividual PK variability; conduct of targeted studies on special populations (including children); and measurement of PK-PD parameters at the site of disease.</p>","PeriodicalId":73468,"journal":{"name":"International journal of pharmacokinetics","volume":"2 3","pages":"195-212"},"PeriodicalIF":0.0,"publicationDate":"2017-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4155/ipk-2017-0004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36544898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 14
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