{"title":"Opportunities and trends of transcutaneous auricular vagus nerve stimulation","authors":"Chen Xin, Yuzhengheng Zhang, Jing Guo, Yu Wang, Yifei Wang, Ya’nan Zhao, Ningyi Zou, Shaoyuan Li, Peijing Rong","doi":"10.54844/gmiw.2024.0519","DOIUrl":"https://doi.org/10.54844/gmiw.2024.0519","url":null,"abstract":"Background: After more than two decades of development, transcutaneous auricular vagus nerve stimulation (taVNS) has surpassed its role as a mere alternative to VNS and is now applied to various disorders. This study presents a bibliometric analysis to evaluate the global scientific output of taVNS research, aiming to describe its current status and identify potential future trends. \u0000Methods: We conducted a systematic retrieval of taVNS-related studies published between 2000 and 2022 from the Web of Science database. VOSviewer was used to construct networks based on country/institution/author co-authorship, journal/reference co-citation analysis, literature citation analysis and keyword co-occurrence. \u0000Results: A total of 523 relevant articles and reviews were included. Since 2012, there has been a rapid increase in publications and citations. China emerged as the leading contributor in terms of publication output, while Germany had the highest number of citations. Interestingly, research groups from different countries exhibited distinct research ideas and characteristics concerning taVNS, yet collaboration between these groups remained limited. Through a focused examination of key aspects in this field, we identified significant opportunities for the future advancement of taVNS. \u0000Conclusion: This bibliometric analysis emphasizes the interest in and recognition of taVNS as a therapeutic intervention and identifies broader clinical applications, more precise stimulation, and the development and commercialization of wearable devices as key opportunities and challenges for the future.","PeriodicalId":73188,"journal":{"name":"Gut microbiota and integrative wellness","volume":"34 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141376389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Bioelectronic medicine for restoring autonomic balance in autoimmune diseases.","authors":"Victor Pikov","doi":"10.54844/gmiw.2022.0182","DOIUrl":"10.54844/gmiw.2022.0182","url":null,"abstract":"<p><p>The aim of this mini-review is to introduce most prevalent autoimmune diseases, emphasize the importance of sympatho-parasympathetic imbalance in these autoimmune diseases, demonstrate how such imbalance can be effectively treated using the bioelectronic medicine, and describe potential mechanisms of bioelectronic medicine effects on the autoimmune activity at the cellular and molecular levels.</p>","PeriodicalId":73188,"journal":{"name":"Gut microbiota and integrative wellness","volume":"1 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10125261/pdf/nihms-1892565.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9443653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Gut microbiota and human wellness: Start from the integrated medicine model","authors":"Bin Cong, Jiande D. Z. Chen, Wei Wei","doi":"10.54844/gmiw.2022.0084","DOIUrl":"https://doi.org/10.54844/gmiw.2022.0084","url":null,"abstract":"","PeriodicalId":73188,"journal":{"name":"Gut microbiota and integrative wellness","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74776801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Clinical application of acupuncture and Chinese materia medica in the treatment of gastrointestinal dysfunction under the mode of traditional Chinese medicine","authors":"Jing-jun Zhao, Cuiling Feng, Peijing Rong","doi":"10.54844/gmiw.2022.0090","DOIUrl":"https://doi.org/10.54844/gmiw.2022.0090","url":null,"abstract":"In China, Chinese materia medica and acupuncture have been applied as effective methods for the treatment of gastrointestinal dysfunction for several thousand years. In fact, traditional Chinese medicine (TCM), especially acupuncture, has been gradually accepted by practitioners and patients all over the world. However, due to lack of systematic and comprehensive review articles, the effects of acupuncture and Chinese materia medica under the TCM mode have not been clearly elaborated. Therefore, in this review, we discussed the potential clinical value of acupuncture and Chinese materia medica in the treatment of gastrointestinal dysfunction under the TCM model. Articles published in the past 10 years were searched with \"acupuncture,\" \"gastrointestinal dysfunction,\" \"gastrointestinal disorders,\" and other relevant keywords. In the following review, the author expounded the effects of TCM on gastrointestinal function and its potential value from the perspective of acupuncture for gastrointestinal dysfunction, Chinese materia medica for gastrointestinal dysfunction, and the combination of acupuncture and Chinese materia medica.","PeriodicalId":73188,"journal":{"name":"Gut microbiota and integrative wellness","volume":"44 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75308451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Guangdong Tong, W. Zhong, Deti Peng, Xiaoyan Jiang, Tianran Zhou, Furong Huang, C. Tian, Chunshan Wei, Y. Xing, Jing Yuan, Jian Yang, Jin Wu, Jiong Yang, Che-ching Huang, Zhijun Qu
{"title":"Association of reduced renal function with different phase of chronic hepatitis B virus infection","authors":"Guangdong Tong, W. Zhong, Deti Peng, Xiaoyan Jiang, Tianran Zhou, Furong Huang, C. Tian, Chunshan Wei, Y. Xing, Jing Yuan, Jian Yang, Jin Wu, Jiong Yang, Che-ching Huang, Zhijun Qu","doi":"10.54844/gmiw.2022.0181","DOIUrl":"https://doi.org/10.54844/gmiw.2022.0181","url":null,"abstract":"Background: The association between chronic hepatitis B virus (HBV) infection and the development of chronic kidney disease (CKD) remains controversial, and whether the cause is related to the different phases of chronic HBV infection remains unclear. Methods: A large cross-sectional study was performed to show the prevalence of reduced renal function during chronic HBV infection in adults from 7 multi-centers of Shenzhen City in China. Estimated glomerular filtration rate (eGFR) was used to evaluate the effect of HBV infection on the risk of renal impairment. Results: 33.04% HBsAg (+) patients had eGFR < 90, while patients without HBV exposure, 32.73% had eGFR < 90, showing no significant difference. There was no significant difference between those with elevated and normal alanine aminotransferase (ALT) in chronic hepatitis B (CHB) groups. Moreover, according to stratified statistics of different phases of the disease, liver cirrhosis, especially decompensated liver cirrhosis, hepatocellular carcinoma (HCC) showed a significant decrease in renal function compared with CBH (P = 0). Multivariate logistic regression analysis showed that liver disease different phases independently associated with reduced renal function. Conclusion: During the early CHB phase of chronic HBV infection (either elevated ALT or normal) did not increase the risk of renal dysfunction compares no exposure to HBV. However, when CHB progress to end-stage liver disease were associated with reduced kidney function. Additionally, Hoek formula should be recommended for patients with end-stage liver disease.","PeriodicalId":73188,"journal":{"name":"Gut microbiota and integrative wellness","volume":"45 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77269150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Helicobacter pylori interpretation in 2022","authors":"A. Tay, B. Marshall","doi":"10.54844/gmiw.2022.0089","DOIUrl":"https://doi.org/10.54844/gmiw.2022.0089","url":null,"abstract":"Helicobacter pylori, or formally known as Campylobacter pylori, is a Gram negative, micro-aerophilic, spiral microorganism that can colonise the healthy stomach lining. It is associated with gastritis, peptic ulcer disease, mucosa-associated lymphoid tissue (MALT) lymphoma, and gastric cancer.[1–3] At least 50% of the world population is still infected with H. pylori and about 1 million new gastric cancer cases are reported annually.[4] In 1994 and 2017, the WHO classified H. pylori as a Class I carcinogen[5,6] and listed it as one of the most important (priority high) pathogens for emerging antibiotic resistance alarm,[7,8] respectively.","PeriodicalId":73188,"journal":{"name":"Gut microbiota and integrative wellness","volume":"69 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81853295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yang Yang, Zijing Tao, Shuangshuang Fang, Ping Zhang, Wei Wei
{"title":"Practice and thinking on the traditional Chinese medicine treatment of chronic atrophic gastritis based on pathological evaluation","authors":"Yang Yang, Zijing Tao, Shuangshuang Fang, Ping Zhang, Wei Wei","doi":"10.54844/gmiw.2022.0091","DOIUrl":"https://doi.org/10.54844/gmiw.2022.0091","url":null,"abstract":"Chronic atrophic gastritis is a precancerous gastric disease with intestinal epithelial hyperplasia and heterogeneous proliferation based on mucosal atrophy. In recent years, the international guidelines and consensus on the treatment of precancerous gastric disease have been gradually updated, emphasizing the treatment of precancerous gastric disease and lesions based on the pathological changes as the outcome. Chinese medicine is widely used in the clinical treatment of chronic atrophic gastritis, but there are fewer research ideas of Chinese medicine based on the pathological evaluation of the results. In this article, the pathological concepts related to chronic atrophic gastritis and the clinical research ideas and practice strategies of traditional Chinese medicine based on the evaluation of pathological outcomes are compiled.","PeriodicalId":73188,"journal":{"name":"Gut microbiota and integrative wellness","volume":" 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72382659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Peijing Rong, Liwei Hou, Yang Yang, Xiaoying Luo, Junying Wang, Jinling Zhang, Jiande D. Z. Chen, Wei Wei
{"title":"Multi-targeting regulation of auricular vagus nerve stimulation on gastric hypersensitivity and gastric dysmotility in a rodent model of functional dyspepsia","authors":"Peijing Rong, Liwei Hou, Yang Yang, Xiaoying Luo, Junying Wang, Jinling Zhang, Jiande D. Z. Chen, Wei Wei","doi":"10.54844/gmiw.2022.0088","DOIUrl":"https://doi.org/10.54844/gmiw.2022.0088","url":null,"abstract":"Background: Evidences have shown the auricular vagus nerve stimulation (aVNS) is effective for functional dyspepsia (FD) recently. This study aimed to observe the mechanism of aVNS on facilitatory mediators of the inflammation in a rat model of functional dyspepsia. Methods: Thirty-six 5 d-old male Sprague Dawley rats were randomly divided into control groups (n = 12), model group (n = 12), aVNS group (n = 6) and sham-aVNS group (n = 6). Except for the control rats, all other rats were treated with iodoacetamide gavage. After the model was developed successfully, rats in aVNS group and sham-aVNS group received aVNS and sham-aVNS respectively, 30 min/1 time per day for 14 consecutive days. The control group and model group received no intervention. Gastric sensitivity after 1-week of intervention and gastric emptying after 2-week of intervention were adopted to assess the effect of aVNS. Brain-gut peptides, facilitatory mediators of the inflammation in serum were tested by ELISA, and α7 nicotinic acetylcholine receptor (α7-nAchR) in antrum tissue were tested by Immunohistochemistry to explore the mechanism of aVNS. Results: Compared with the control group, the gastric sensitivity was increased, gastric emptying decreased, and there was no structural damage in the gastric antrum in the model group. aVNS reduced visceral hypersensitivity and improved gastric emptying but not sham-aVNS. cholecystokinin, glucagon-like peptide-1, peptide, tumor necrosis factorα and interleukin 6 were all increased, while ghrelin and α7-nAchR decreased in model rats (P < 0.01 for all, compared with the control group). aVNS can normalize them. Conclusion: The aVNS can decrease the gastric sensitivity and increase gastric emptying, the mechanism was related to its regulation of brain-gut peptides and facilitatory mediators of the inflammation. The ameliorating effect was related to cholinergic mechanism.","PeriodicalId":73188,"journal":{"name":"Gut microbiota and integrative wellness","volume":"44 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77820965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}