临床诊断学期刊(英文)最新文献

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Case Report of a Chronic Wound Due to Venous Insufficiency Following a Traumatic Arteriovenous Fistula. 外伤性动静脉瘘后静脉功能不全致慢性伤口1例报告。
临床诊断学期刊(英文) Pub Date : 2021-06-01 Epub Date: 2021-06-29 DOI: 10.4236/ojcd.2021.112003
Jialiang Chen, Louis Chebli
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引用次数: 2
SCNH2 is a novel apelinergic family member acting as a potent mitogenic and chemotactic factor for both endothelial and epithelial cells. SCNH2是一种新的apelinergic家族成员,在内皮细胞和上皮细胞中都是一种有效的有丝分裂和趋化因子。
临床诊断学期刊(英文) Pub Date : 2013-06-01 DOI: 10.4236/ojcd.2013.32009
Changge Fang, Ingalill Avis, Caterina Bianco, Natalie Held, Jennifer Morris, Kris Ylaya, Stephen M Hewitt, Alfred C Aplin, Roberto F Nicosia, Laura A Fung, John D Lewis, William G Stetler-Stevenson, David S Salomon, Frank Cuttitta
{"title":"SCNH2 is a novel apelinergic family member acting as a potent mitogenic and chemotactic factor for both endothelial and epithelial cells.","authors":"Changge Fang,&nbsp;Ingalill Avis,&nbsp;Caterina Bianco,&nbsp;Natalie Held,&nbsp;Jennifer Morris,&nbsp;Kris Ylaya,&nbsp;Stephen M Hewitt,&nbsp;Alfred C Aplin,&nbsp;Roberto F Nicosia,&nbsp;Laura A Fung,&nbsp;John D Lewis,&nbsp;William G Stetler-Stevenson,&nbsp;David S Salomon,&nbsp;Frank Cuttitta","doi":"10.4236/ojcd.2013.32009","DOIUrl":"https://doi.org/10.4236/ojcd.2013.32009","url":null,"abstract":"<p><p>The gut hormone apelin is a major therapeutic focus for several diseases involving inflammation and aberrant cell growth. We investigated whether apelin-36 contained alternative bioactive peptides associated with normal physiology or disease. Amino acid sequence analysis of apelin-36 identified an amidation motif consistent with the formation of a secondary bioactive peptide (SCNH2). SCNH2 is proven to be mitogenic and chemotactic in normal/malignant cells and augments angiogenesis via a PTX-resistant/CT-X-sensitive G protein-coupled receptor (GPCR). Notably, SCNH2 is substantially more potent and sensitive than apelin-13 and vascular endothelial growth factor-A. Endogenous SCNH2 is highly expressed in human tumors and placenta and in mouse embryonic tissues. Our findings demonstrate that SCNH2 is a new apelinergic member with critical pluripotent roles in angiogenesis related diseases and embryogenesis via a non-APJ GPCR.</p>","PeriodicalId":68469,"journal":{"name":"临床诊断学期刊(英文)","volume":"3 2","pages":"37-51"},"PeriodicalIF":0.0,"publicationDate":"2013-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3743796/pdf/nihms3152.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31667663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
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