世界高血压杂志最新文献

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Endocrine hypertension: An overview on the current etiopathogenesis and management options. 内分泌高血压:目前的发病机制和管理方案的概述。
世界高血压杂志 Pub Date : 2015-01-01 DOI: 10.5494/wjh.v5.i2.14
Reena M Thomas, Ewa Ruel, Prapimporn Ch Shantavasinkul, Leonor Corsino
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引用次数: 30
Oxidative stress-mediated effects of angiotensin II in the cardiovascular system. 氧化应激介导的血管紧张素II在心血管系统中的作用。
世界高血压杂志 Pub Date : 2012-08-23 DOI: 10.5494/wjh.v2.i4.34
Hairuo Wen, Judith K Gwathmey, Lai-Hua Xie
{"title":"Oxidative stress-mediated effects of angiotensin II in the cardiovascular system.","authors":"Hairuo Wen,&nbsp;Judith K Gwathmey,&nbsp;Lai-Hua Xie","doi":"10.5494/wjh.v2.i4.34","DOIUrl":"https://doi.org/10.5494/wjh.v2.i4.34","url":null,"abstract":"<p><p>Angiotensin II (Ang II), an endogenous peptide hormone, plays critical roles in the pathophysiological modulation of cardiovascular functions. Ang II is the principle effector of the renin-angiotensin system for maintaining homeostasis in the cardiovascular system, as well as a potent stimulator of NAD(P)H oxidase, which is the major source and primary trigger for reactive oxygen species (ROS) generation in various tissues. Recent accumulating evidence has demonstrated the importance of oxidative stress in Ang II-induced heart diseases. Here, we review the recent progress in the study on oxidative stress-mediated effects of Ang II in the cardiovascular system. In particular, the involvement of Ang II-induced ROS generation in arrhythmias, cell death/heart failure, ischemia/reperfusion injury, cardiac hypertrophy and hypertension are discussed. Ca<sup>2+</sup>/calmodulin-dependent protein kinase II is an important molecule linking Ang II, ROS and cardiovascular pathological conditions.</p>","PeriodicalId":66493,"journal":{"name":"世界高血压杂志","volume":"2 4","pages":"34-44"},"PeriodicalIF":0.0,"publicationDate":"2012-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3936474/pdf/nihms548534.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32168732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 86
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