中国细胞生物学学报最新文献

筛选
英文 中文
[Physiological Function and Structural Basis of Bcl-2 Family Proteins]. Bcl-2家族蛋白的生理功能和结构基础
中国细胞生物学学报 Pub Date : 2019-08-01 Epub Date: 2019-09-12
冯 健愉, 朱 玉山, 权 陈, 林家 凌, Feng Jianyu, Zhu Yushan, Chen Quan, Lin Jialing
{"title":"[Physiological Function and Structural Basis of Bcl-2 Family Proteins].","authors":"冯 健愉,&nbsp;朱 玉山,&nbsp;权 陈,&nbsp;林家 凌,&nbsp;Feng Jianyu,&nbsp;Zhu Yushan,&nbsp;Chen Quan,&nbsp;Lin Jialing","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Apoptosis is an important biological process that plays a key role in the regulation of cell fate and homeostasis. The B-cell lymphoma-2 (Bcl-2) family proteins are important regulators of the apoptotic pathway, and their dysfunction is associated with a variety of diseases, including cancer, neurodegenerative and autoimmune diseases. In the past decade, a large number of research work on the physiological functions and atomic structures of Bcl-2 family proteins have been reported, which has deepened our understanding of the molecular mechanism and pathological significance of Bcl-2 family proteins. Recently, new drugs targeting different Bcl-2 proteins have been developed and used in clinics or tested in clinical trials. However, the complexity and diversity in functions and structures of Bcl-2 family have left many unsolved problems. This article summarizes current knowledge of the structure and function of Bcl-2 family proteins and discusses the pharmacological significance of Bcl-2 proteins as effective therapeutic targets.</p>","PeriodicalId":60745,"journal":{"name":"中国细胞生物学学报","volume":"41 8","pages":"1477-1489"},"PeriodicalIF":0.0,"publicationDate":"2019-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8265309/pdf/nihms-1063538.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39174141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信