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阿尔茨海默氏病研究进展(英文)最新文献

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The computerized LASSI-BC Test versus the Standard LASSI-L Paper-and-Pencil Version in Community-Based-Samples. 社区样本中的计算机化 LASSI-BC 测试与标准 LASSI-L 纸笔版对比。
阿尔茨海默氏病研究进展(英文) Pub Date : 2024-03-01 Epub Date: 2024-03-29 DOI: 10.4236/aad.2024.131002
Rosie E Curiel Cid, Alexandra Ortega, Ubbo Visser, Marcela Kitaigorodsky, D Diane Zheng, Diana Hincapie, Kirsten Horne Crenshaw, Ashleigh Beaulieu, Brooke Bosworth, Liz Gallardo, Emory Neer, Sofia Ramirez, Elizabeth A Crocco, Mike Georgiou, Efrosyni Sfakianaki, David A Loewenstein
{"title":"The computerized LASSI-BC Test versus the Standard LASSI-L Paper-and-Pencil Version in Community-Based-Samples.","authors":"Rosie E Curiel Cid, Alexandra Ortega, Ubbo Visser, Marcela Kitaigorodsky, D Diane Zheng, Diana Hincapie, Kirsten Horne Crenshaw, Ashleigh Beaulieu, Brooke Bosworth, Liz Gallardo, Emory Neer, Sofia Ramirez, Elizabeth A Crocco, Mike Georgiou, Efrosyni Sfakianaki, David A Loewenstein","doi":"10.4236/aad.2024.131002","DOIUrl":"10.4236/aad.2024.131002","url":null,"abstract":"<p><p>Proactive Semantic Interference (PSI) and failure to recover from PSI (frPSI), are novel constructs assessed by the LASSI-L. These measures are sensitive to cognitive changes in early Mild Cognitive Impairment (MCI) and preclinical AD determined by A<i>β</i> load using PET. The goal of this study was to compare a new computerized version of the LASSI-L (LASSI-Brief Computerized) to the standard paper-and-pencil version of the test. In this study, we examined 110 cognitively unimpaired (CU) older adults and 79 with amnestic MCI (aMCI) who were administered the paper-and-pencil form of the LASSI-L. Their performance was compared with 62 CU older adults and 52 aMCI participants examined using the LASSI-BC. After adjustment for covariates (degree of initial learning, sex, education, and language of evaluation) both the standard and computerized versions distinguished between aMCI and CU participants. The performance of CU and aMCI groups using either form was relatively commensurate. Importantly, an optimal combination of Cued B2 recall and Cued B1 intrusions on the LASSI-BC yielded an area under the ROC curve of .927, a sensitivity of 92.3% and specificity of 88.1%, relative to an area under the ROC curve of .815, a sensitivity of 72.5%, and a specificity of 79.1% obtained for the paper-and-pencil LASSI-L. Overall, the LASSI-BC was comparable, and in some ways, superior to the paper-and-pencil LASSI-L. Advantages of the LASSI-BC include a more standardized administration, suitability for remote assessment, and an automated scoring mechanism that can be verified by a built-in audio recording of responses.</p>","PeriodicalId":57126,"journal":{"name":"阿尔茨海默氏病研究进展(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11259231/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141735802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Brain-Gut Axis in Alzheimer’s Disease 阿尔茨海默病中的脑-肠轴
阿尔茨海默氏病研究进展(英文) Pub Date : 2023-01-01 DOI: 10.4236/aad.2023.123003
M. Patel
{"title":"The Brain-Gut Axis in Alzheimer’s Disease","authors":"M. Patel","doi":"10.4236/aad.2023.123003","DOIUrl":"https://doi.org/10.4236/aad.2023.123003","url":null,"abstract":"","PeriodicalId":57126,"journal":{"name":"阿尔茨海默氏病研究进展(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79474590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Systematic Review and Meta-Analysis of Randomized Control Trials to Check Role of Non-Steroidal Anti-inflammatory Drugs as Protective Factor in Alzheimer Disease Subjects 非甾体抗炎药作为阿尔茨海默病患者保护因子作用的随机对照试验的系统评价和meta分析
阿尔茨海默氏病研究进展(英文) Pub Date : 2023-01-01 DOI: 10.4236/aad.2023.121001
A. Asthana, S. Tripathi, R. Agarwal
{"title":"A Systematic Review and Meta-Analysis of Randomized Control Trials to Check Role of Non-Steroidal Anti-inflammatory Drugs as Protective Factor in Alzheimer Disease Subjects","authors":"A. Asthana, S. Tripathi, R. Agarwal","doi":"10.4236/aad.2023.121001","DOIUrl":"https://doi.org/10.4236/aad.2023.121001","url":null,"abstract":"","PeriodicalId":57126,"journal":{"name":"阿尔茨海默氏病研究进展(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87606969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Novel Computerized Cognitive Test for the Detection of Mild Cognitive Impairment and Its Association with Neurodegeneration in Alzheimer’s Disease Prone Brain Regions 一种新的计算机认知测试，用于检测轻度认知障碍及其与阿尔茨海默病易发脑区神经变性的关系
阿尔茨海默氏病研究进展(英文) Pub Date : 2023-01-01 DOI: 10.4236/aad.2023.123004
Rosie E. Curiel Cid, D. Diane Zheng, Marcela Kitaigorodsky, Malek Adjouadi, Elizabeth A. Crocco, Mike Georgiou, Christian Gonzalez-Jimenez, Alexandra Ortega, Mohammed Goryawala, Natalya Nagornaya, Pradip Pattany, Efrosyni Sfakianaki, Ubbo Visser, David A. Loewenstein
{"title":"A Novel Computerized Cognitive Test for the Detection of Mild Cognitive Impairment and Its Association with Neurodegeneration in Alzheimer’s Disease Prone Brain Regions","authors":"Rosie E. Curiel Cid, D. Diane Zheng, Marcela Kitaigorodsky, Malek Adjouadi, Elizabeth A. Crocco, Mike Georgiou, Christian Gonzalez-Jimenez, Alexandra Ortega, Mohammed Goryawala, Natalya Nagornaya, Pradip Pattany, Efrosyni Sfakianaki, Ubbo Visser, David A. Loewenstein","doi":"10.4236/aad.2023.123004","DOIUrl":"https://doi.org/10.4236/aad.2023.123004","url":null,"abstract":"","PeriodicalId":57126,"journal":{"name":"阿尔茨海默氏病研究进展(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135400562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Studying Alzheimer’s Disease Using Drosophila melanogaster as a Powerful Tool 利用黑腹果蝇研究阿尔茨海默病
阿尔茨海默氏病研究进展(英文) Pub Date : 2022-01-01 DOI: 10.4236/aad.2022.113003
J. Kasanin, Xing-bin Wang, W. Jiao, Qiuyu Li, B. Lu
{"title":"Studying Alzheimer’s Disease Using <i>Drosophila melanogaster</i> as a Powerful Tool","authors":"J. Kasanin, Xing-bin Wang, W. Jiao, Qiuyu Li, B. Lu","doi":"10.4236/aad.2022.113003","DOIUrl":"https://doi.org/10.4236/aad.2022.113003","url":null,"abstract":"","PeriodicalId":57126,"journal":{"name":"阿尔茨海默氏病研究进展(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72938688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
High Fat Diet Alteration of Gut Microbiota Impacts Learning, Memory and Anxiety Response in Mice: Cannabidiol and Omega 3 Possible Remedies 高脂肪饮食改变肠道微生物群对小鼠学习、记忆和焦虑反应的影响:大麻二酚和欧米茄3可能的补救措施
阿尔茨海默氏病研究进展(英文) Pub Date : 2022-01-01 DOI: 10.4236/aad.2022.111001
I. Abi, Moses Ashiekaa, Eugenia Abi, O. Adeniyi, L. Saalu
{"title":"High Fat Diet Alteration of Gut Microbiota Impacts Learning, Memory and Anxiety Response in Mice: Cannabidiol and Omega 3 Possible Remedies","authors":"I. Abi, Moses Ashiekaa, Eugenia Abi, O. Adeniyi, L. Saalu","doi":"10.4236/aad.2022.111001","DOIUrl":"https://doi.org/10.4236/aad.2022.111001","url":null,"abstract":"","PeriodicalId":57126,"journal":{"name":"阿尔茨海默氏病研究进展(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86660180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
A Short Review of the Literature on Assistive Technologies for Alzheimer’s Patients and Their Caregivers 关于阿尔茨海默病患者及其护理人员辅助技术的文献综述
阿尔茨海默氏病研究进展(英文) Pub Date : 2022-01-01 DOI: 10.4236/aad.2022.114005
Deepak R. Chandran
{"title":"A Short Review of the Literature on Assistive Technologies for Alzheimer’s Patients and Their Caregivers","authors":"Deepak R. Chandran","doi":"10.4236/aad.2022.114005","DOIUrl":"https://doi.org/10.4236/aad.2022.114005","url":null,"abstract":"","PeriodicalId":57126,"journal":{"name":"阿尔茨海默氏病研究进展(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75969808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Treatment Efficacy of Photobiomodulation for Moderate and Advanced Dementia or Alzheimer’s Disease: Case Studies 光生物调节治疗中晚期痴呆或阿尔茨海默病的疗效:案例研究
阿尔茨海默氏病研究进展(英文) Pub Date : 2022-01-01 DOI: 10.4236/aad.2022.114004
W. Stephan, L. Banas, Michael R Hamblin
{"title":"Treatment Efficacy of Photobiomodulation for Moderate and Advanced Dementia or Alzheimer’s Disease: Case Studies","authors":"W. Stephan, L. Banas, Michael R Hamblin","doi":"10.4236/aad.2022.114004","DOIUrl":"https://doi.org/10.4236/aad.2022.114004","url":null,"abstract":"Extensive research is ongoing in the use of photobiomodulation (PBM, often referred to as low level laser therapy) to treat Alzheimer's disease or dementia. The following case studies further confirm that PBM could be a breakthrough approach to limit the progression of this insidious disease. We present four cases, two with mild to moderate dementia and two with more advanced symptoms. Several publications have shown beneficial results, however, several weeks of daily treatments were necessary. The cases described here suggest that moderate or advanced dementia cases can be significantly improved with three or four eight-minute treatments over a 5- 7-day period (MWF).","PeriodicalId":57126,"journal":{"name":"阿尔茨海默氏病研究进展(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79629696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Alzheimer’s Disease (AD): Risks, Treatments, Prevention, and Future Implementations 阿尔茨海默病(AD):风险、治疗、预防和未来实施
阿尔茨海默氏病研究进展(英文) Pub Date : 2022-01-01 DOI: 10.4236/aad.2022.112002
T. Huma, Rukhsana Nawaz, Xiaohua Li, Andrew Willden
{"title":"Alzheimer’s Disease (AD): Risks, Treatments, Prevention, and Future Implementations","authors":"T. Huma, Rukhsana Nawaz, Xiaohua Li, Andrew Willden","doi":"10.4236/aad.2022.112002","DOIUrl":"https://doi.org/10.4236/aad.2022.112002","url":null,"abstract":"Alzheimer’s disease (AD) is the most common type of dementia found among geriatric populations worldwide and is growing quickly in low- and middle-income countries. Alzheimer’s disease affects approximately 36.6 mil-lion people, and that number is expected to double over the next two decades. Those most susceptible to Alzheimer’s are over the age of 60, though other associated factors such as sex, poor nutrition, education, impaired functional status, body mass index, diabetes, depression, smoking, alcohol, fish intake, and pesticide exposure have been reported, though none are clear. Gaining a better understanding of the etiology of AD requires multiple-site-targeted therapy to control the disease at the initial level. On the other hand, evidence suggests that risk factors for AD are modifiable. Hence reduction in associated risk factors may require very long follow-ups to make people aware of their effect on AD incidence. If these factors are effective in preventing the progression of AD, the target populations could be affected at the early stages of AD or even patients with more advanced disease.","PeriodicalId":57126,"journal":{"name":"阿尔茨海默氏病研究进展(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90387225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
We Should Apply a “One Health” Approach to Understand and Treat Alzheimer’s Disease 我们应该用“同一个健康”的方法来认识和治疗阿尔茨海默病
阿尔茨海默氏病研究进展(英文) Pub Date : 2021-07-14 DOI: 10.4236/aad.2021.103004
A. White
{"title":"We Should Apply a “One Health” Approach to Understand and Treat Alzheimer’s Disease","authors":"A. White","doi":"10.4236/aad.2021.103004","DOIUrl":"https://doi.org/10.4236/aad.2021.103004","url":null,"abstract":"Despite many decades of researches and large numbers of clinical trials, there remain no effective treatments for Alzheimer’s disease, a major degenerative ageing brain disorder. The potential treatments have focused on targeting the accumulation of amyloid beta-peptide in the brains of patients, but without success in slowing the disease. Many studies have now identified a large range of pathological changes (i.e. altered immune activity, mitochondrial impairment, abnormal microbiome), and links to the external environment (i.e. associations with infections, the influence of air pollution). While the concept of One Health (which considers links between the environment and human disease) has traditionally been applied to the understanding of the human infectious disease, it is argued here that the One Health approach should be adopted for Alzheimer’s disease. This would provide a far more holistic understanding of the disease, and its relationship to a growing number of exogenous factors, as well as could potentially lead to new treatment options targeted at the confluence of external influences, and internal molecular pathways.","PeriodicalId":57126,"journal":{"name":"阿尔茨海默氏病研究进展(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72468815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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