老年问题研究(英文)最新文献

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Evaluation of health determinants for sustaining workability in aging US workforce. 美国老龄化劳动力中维持工作能力的健康决定因素评估
老年问题研究(英文) Pub Date : 2013-08-01 DOI: 10.4236/aar.2013.23015
Vatsalya Vatsalya, Robert Karch
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引用次数: 5
Increased vitamin D is associated with decline of naïve, but accumulation of effector, CD8 T cells during early aging. 维生素D的增加与naïve的下降有关,但在衰老早期,效应CD8 T细胞的积累有关。
老年问题研究(英文) Pub Date : 2013-05-01 DOI: 10.4236/aar.2013.22010
Yong Gil Hwang, Hui-Chen Hsu, Fei-Chu Lim, Qi Wu, PingAr Yang, Gordon Fisher, Gary R Hunter, John D Mountz
{"title":"Increased vitamin D is associated with decline of naïve, but accumulation of effector, CD8 T cells during early aging.","authors":"Yong Gil Hwang,&nbsp;Hui-Chen Hsu,&nbsp;Fei-Chu Lim,&nbsp;Qi Wu,&nbsp;PingAr Yang,&nbsp;Gordon Fisher,&nbsp;Gary R Hunter,&nbsp;John D Mountz","doi":"10.4236/aar.2013.22010","DOIUrl":"https://doi.org/10.4236/aar.2013.22010","url":null,"abstract":"<p><p>Given the protective roles of 25-hydroxyvitamin D (25[OH]D or vitamin D) in musculoskeletal health and the potential beneficial effects of vitamin D supplementation in reducing the risk of various chronic diseases, intensive repletion of vitamin D has been widely advocated. Of note, CD8 T cells have the highest levels of the vitamin D receptor compared with other major immune cells. The effects of vitamin D on CD8 T cells during aging, however, remain unclear. This study determined the relationship between vitamin D levels and CD8 T-cell status in 34 healthy female subjects (all >60 years old). The CD8 T cell phenotype was defined by the surface expression of CD28 and CD95. The low-25(OH)D serum groups (≤30 ng/ml) had higher percentages of CD28<sup>+</sup>CD95<sup>-</sup>CD8<sup>+</sup> (naïve) T cells and lower percentages of CD28<sup>+</sup>CD95<sup>+</sup>CD8<sup>+</sup> (effector) T cells. By contrast, subjects with high levels of 25(OH)D had very low percentages of naïve CD8 T cells but very high percentages of effector CD8 T cells. There was a significant inverse correlation between 25(OH)D levels and the frequency of naïve CD8 T cells. The results show that higher levels of vitamin D are correlated with decreased frequencies of naïve CD8 T cells during early aging, suggesting that higher levels of 25(OH)D accelerate CD8 T-cell senescence. These results warrant the further evaluation of the effects of vitamin D supplementation in immune aging.</p>","PeriodicalId":56467,"journal":{"name":"老年问题研究(英文)","volume":"2 2","pages":"72-80"},"PeriodicalIF":0.0,"publicationDate":"2013-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4226219/pdf/nihms514513.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32811904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 11
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