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Nobiletin Protects against Acute Liver Injury via Targeting c‑Jun N‑Terminal Kinase (JNK)-Induced Apoptosis of Hepatocytes 诺比列素通过靶向c - Jun N -末端激酶（JNK）诱导的肝细胞凋亡来保护急性肝损伤

Figshare Pub Date : 2020-06-14 DOI: 10.1021/acs.jafc.0c01722.s001

Mengmeng Li (400335), Hui Zhao (7395), Jiayan Wu (204411), Liwen Wang (276995), Juan Wang (115708), Ke Lv (301960), Shuangqing Liu (5597231), Meiyan Wang (386182), Wenqiang Guan (8565006), Jianfu Liu (8565009), Chi-Tang Ho (195145), Shiming Li (708834)

{"title":"Nobiletin Protects against Acute Liver Injury via Targeting c‑Jun N‑Terminal Kinase (JNK)-Induced Apoptosis of Hepatocytes","authors":"Mengmeng Li (400335), Hui Zhao (7395), Jiayan Wu (204411), Liwen Wang (276995), Juan Wang (115708), Ke Lv (301960), Shuangqing Liu (5597231), Meiyan Wang (386182), Wenqiang Guan (8565006), Jianfu Liu (8565009), Chi-Tang Ho (195145), Shiming Li (708834)","doi":"10.1021/acs.jafc.0c01722.s001","DOIUrl":"https://doi.org/10.1021/acs.jafc.0c01722.s001","url":null,"abstract":"Acute liver injury resultingnfrom several factors such as medication, food toxins, and herbal supplementationnoften leads to a severe health condition and makes treatment difficult;nthereby, the prevention of acute liver injury remains a critical issuenand is of great importance. In this study, we investigated the preventiveneffects of nobiletin (NOB) on a mouse model of concanavalin A (ConA)-inducednacute liver injury. We observed that NOB (10 mg/kg) pretreatment ofnConA-treated mice significantly lowered the levels of liver enzymesnincluding alanine aminotransferase (ALT) and aspartate aminotransferasen(AST), decreased the intracellular generation of reactive oxygen speciesn(ROS), and suppressed the release of inflammatory cytokines such asntumor necrosis factor-α (TNF-α) and interferon-γn(IFN-γ). Pathological data suggested that pretreatment withnNOB ameliorated ConA-induced liver damage by promoting proliferationnand alleviating apoptosis of hepatocytes. Furthermore, significantnsuppression of the c-Jun-activating kinase (JNK) signal was also observednin NOB-pretreated liver tissues compared with that of ConA treatmentnonly. In addition, an <i>in vitro</i> mechanism study confirmednthat the addition of NOB protected hepatocytes via inhibition of JNKnactivation, manifesting that alleviation of JNK-induced apoptosisnof hepatocytes is correlated with NOB protection in acute liver injury.","PeriodicalId":523789,"journal":{"name":"Figshare","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147921983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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