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Neurotrophin-3-Loaded Multichannel Nanofibrous ScaffoldsnPromoted Anti-Inflammation, Neuronal Differentiation, and FunctionalnRecovery after Spinal Cord Injury 负载神经营养因子-3的多通道纳米纤维支架促进脊髓损伤后的抗炎、神经元分化和功能恢复

Figshare Pub Date : 2020-01-20 DOI: 10.1021/acsbiomaterials.0c00023.s003

Xiumin Sun (6651242), Chi Zhang (9857), Jinghui Xu (8368566), Hong Zhai (524629), Sheng Liu (279488), Yiwei Xu (6651245), Yong Hu (171926), Houqing Long (8368569), Ying Bai (107853), Daping Quan (581083)

{"title":"Neurotrophin-3-Loaded Multichannel Nanofibrous ScaffoldsnPromoted Anti-Inflammation, Neuronal Differentiation, and FunctionalnRecovery after Spinal Cord Injury","authors":"Xiumin Sun (6651242), Chi Zhang (9857), Jinghui Xu (8368566), Hong Zhai (524629), Sheng Liu (279488), Yiwei Xu (6651245), Yong Hu (171926), Houqing Long (8368569), Ying Bai (107853), Daping Quan (581083)","doi":"10.1021/acsbiomaterials.0c00023.s003","DOIUrl":"https://doi.org/10.1021/acsbiomaterials.0c00023.s003","url":null,"abstract":"Thenclinical therapeutics for nerve tissue regeneration and functionalnrecovery after spinal cord injury (SCI) are very limited because ofnthe complex biological processes and inhibitory microenvironment.nAdvanced biomaterials are highly desired to avoid severe secondaryndamage and provide guidance for axonal regrowth. Multichannel nanofibrousnscaffolds were modified with gelatin and cross-linked by genipin.nThe gelatin-coated nanofibers exhibited strong binding affinity withnneurotrophin-3, which underwent a well-controlled release and highlynpromoted neuronal differentiation and synapse formation of the seedednneural stem cells. The nanofibrous scaffolds fabricated by combinatorialnbiomaterials were implanted into complete transected spinal cordsnin rats. Not only were the inflammatory responses and collagen/astrocyticnscar formation limited, but the functional neurons and remyelinationnwere facilitated postsurgery, leading to highly improved functionalnrestoration. This nanofibrous scaffold with high specific surfacenarea can be easily modified with biomolecules, which was proven tonbe effective for nerve regeneration after transected SCI, and providedna springboard for advanced scaffold design in clinical applications.","PeriodicalId":523779,"journal":{"name":"Figshare","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147921791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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