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Bone Marrow Mesenchymal Stem Cells-Derived ExosomalnMiR-29b-3p Regulates Aging-Associated Insulin Resistance 骨髓间充质干细胞来源的外泌体nMiR-29b-3p调节衰老相关的胰岛素抵抗

Figshare Pub Date : 2019-02-11 DOI: 10.1021/acsnano.8b09375.s001

Tian Su (6321764), Yuzhong Xiao (337548), Ye Xiao (3913402), Qi Guo (133147), Changjun Li (2835734), Yan Huang (46805), Qiufang Deng (6321767), Jingxiang Wen (6321770), Fangliang Zhou (6321773), Xiang-Hang Luo (6321776)

{"title":"Bone Marrow Mesenchymal Stem Cells-Derived ExosomalnMiR-29b-3p Regulates Aging-Associated Insulin Resistance","authors":"Tian Su (6321764), Yuzhong Xiao (337548), Ye Xiao (3913402), Qi Guo (133147), Changjun Li (2835734), Yan Huang (46805), Qiufang Deng (6321767), Jingxiang Wen (6321770), Fangliang Zhou (6321773), Xiang-Hang Luo (6321776)","doi":"10.1021/acsnano.8b09375.s001","DOIUrl":"https://doi.org/10.1021/acsnano.8b09375.s001","url":null,"abstract":"Insulinnresistance is the major pathological characteristic ofntype 2 diabetes, and the elderly often develop insulin resistance.nHowever, the deep-seated mechanisms for aging-related insulin resistancenremain unclear. Here, we showed that nanosized exosomes released bynbone marrow mesenchymal stem cells (BM-MSCs) of aged mice could bentaken up by adipocytes, myocytes, and hepatocytes, resulting in insulinnresistance both in vivo and in vitro. Using microRNA (miRNA) array assays, we found that the amount ofnmiR-29b-3p was dramatically increased in exosomes released by BM-MSCsnof aged mice. Mechanistically, SIRT1 (sirtuin 1)nwas identified to function as the downstream target of exosomal miR-29b-3pnin regulating insulin resistance. Notably, utilizing an aptamer-mediatednnanocomplex delivery system that down-regulated the level of miR-29b-3pnin BM-MSCs-derived exosomes significantly ameliorated the insulinnresistance of aged mice. Meanwhile, BM-MSCs-specific overexpressionnof miR-29b-3p induced insulin resistance in young mice. Taken together,nthese findings suggested that BM-MSCs-derived exosomal miR-29b-3pncould modulate aging-related insulin resistance, which may serve asna potential therapeutic target for aging-associated insulin resistance.","PeriodicalId":523743,"journal":{"name":"Figshare","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147921283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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