FigsharePub Date : 2021-05-11DOI: 10.1021/acsami.1c03027.s001
Abhishek Sahu (10783789), Jin Jeon (3876568), Min Suk Lee (3990887), Hee Seok Yang (1320207), Giyoong Tae (1659793)
{"title":"NanozymenImpregnated Mesenchymal Stem Cells for HepaticnIschemia-Reperfusion Injury Alleviation","authors":"Abhishek Sahu (10783789), Jin Jeon (3876568), Min Suk Lee (3990887), Hee Seok Yang (1320207), Giyoong Tae (1659793)","doi":"10.1021/acsami.1c03027.s001","DOIUrl":"https://doi.org/10.1021/acsami.1c03027.s001","url":null,"abstract":"Mesenchymalnstem cell (MSC) based therapy holds great potentialnfor treating numerous diseases owing to their capability to heal injuredntissue/organs through paracrine factors secretion and immunomodulation.nDespite the high hopes, the low viability of transplanted cells innthe injured tissues due to the elevated oxidative stress levels remainsnthe largest obstacle in MSC-based cell therapy. To achieve desiredntherapeutic efficiency, the survival of the transplanted MSCs in thenhigh oxidative stress environment needs to be ensured. Herein, wenproposed the use of a ROS-scavenging nanozyme to protect transplantednMSCs from oxidative stress-mediated apoptosis and thereby improventhe therapeutic effect. Prussian blue (PB) nanoparticles as a biocompatiblenROS-scavenging nanozyme were incorporated into the MSCs without affectingnthe stemness and differentiation potential of MSCs. The nanozyme impregnationnsignificantly improved the survival of MSCs in a high oxidative stressncondition as well as augmented their paracrine effect and anti-inflammatorynproperties, resulting in a profound therapeutic effect in vivo innthe liver ischemia-reperfusion (I/R) injury animal model. Our resultsnindicated that the nanozyme incorporation into MSCs is a simple butnefficient way to improve the therapeutic potential of MSC-based cellntherapy.","PeriodicalId":523702,"journal":{"name":"Figshare","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147920478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}