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Membrane Remodeling by DNA Origami Nanorods: ExperimentsnExploring the Parameter Space for Vesicle Remodeling DNA折纸纳米棒的膜重构：囊泡重构参数空间的实验探索

Figshare Pub Date : 1753-01-01 DOI: 10.1021/acs.langmuir.1c00416.s005

SarahE. Zuraw-Weston (10798828), Mahsa Siavashpouri (10798831), Maria E. Moustaka (10798834), Thomas Gerling (2891756), Hendrik Dietz (1361085), Seth Fraden (1270098), Alexander E. Ribbe (2230687), Anthony D. Dinsmore (2101987)

{"title":"Membrane Remodeling by DNA Origami Nanorods: ExperimentsnExploring the Parameter Space for Vesicle Remodeling","authors":"SarahE. Zuraw-Weston (10798828), Mahsa Siavashpouri (10798831), Maria E. Moustaka (10798834), Thomas Gerling (2891756), Hendrik Dietz (1361085), Seth Fraden (1270098), Alexander E. Ribbe (2230687), Anthony D. Dinsmore (2101987)","doi":"10.1021/acs.langmuir.1c00416.s005","DOIUrl":"https://doi.org/10.1021/acs.langmuir.1c00416.s005","url":null,"abstract":"Inspirednby the ability of cell membranes to alter their shapenin response to bound particles, we report an experimental study ofnlong, slender nanorods binding to lipid bilayer vesicles and alteringnthe membrane shape. Our work illuminates the role of particle concentration,nadhesion strength, and membrane tension in determining the membranenmorphology. We combined giant unilamellar vesicles with oppositelyncharged nanorods, carefully tuning the adhesion strength, membranentension, and particle concentration. With increasing adhesion strength,nthe primary behaviors observed were membrane deformation, vesicle–vesiclenadhesion, and vesicle rupture. These behaviors were observed in well-definednregions in the parameter space with sharp transitions between them.nWe observed the deformation of the membrane resulting in tubulation,ntextured surfaces, and small and large lipid–particle aggregates.nThese responses are robust and repeatable and provide a new physicalnunderstanding of the dependence on the shape, binding affinity, andnparticle concentration in membrane remodeling. The design principlesnderived from these experiments may lead to new bioinspired membrane-basednmaterials.","PeriodicalId":523632,"journal":{"name":"Figshare","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"1753-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147919293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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